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Novel compound for detecting hexanal exhaled by lung cancer patient

A technology of exhaled gas and compounds, applied in the field of new compounds, can solve the problems of expensive, complicated and time-consuming lung cancer diagnosis methods, and achieve the effect of low price, suitable for large-scale census, and fast detection speed

Inactive Publication Date: 2013-01-09
CHONGQING UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0007] Aiming at the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a novel compound for the specific detection of hexanal gas, which is used for the detection of lung cancer by respiratory diagnosis, and solves the problems of complex, time-consuming and expensive conventional diagnostic methods for lung cancer

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  • Novel compound for detecting hexanal exhaled by lung cancer patient
  • Novel compound for detecting hexanal exhaled by lung cancer patient
  • Novel compound for detecting hexanal exhaled by lung cancer patient

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Embodiment Construction

[0026] The novel compounds of the present invention will be further described in detail below in conjunction with specific examples.

[0027] One, a kind of novel compound that is used to detect lung cancer exhaled gas hexanal, its structural formula is:

[0028] ;

[0029] The compound is named: bis-[5-(4-carbonylphenyl)-10,15,20-triphenylporphyrin]-1,2-phthalimide.

[0030] Further, the preparation method of the novel compound for detecting hexanal in exhaled gas of lung cancer comprises the following steps:

[0031] The first step, synthesis of monocarboxyporphyrin:

[0032] 1) Add 200mL propionic acid into a 250mL three-neck flask and heat to boiling;

[0033] 2) Add 2.7g of p-carboxybenzaldehyde and 5.5mL of benzaldehyde to the propionic acid treated in step 1), and stir to fully dissolve p-carboxybenzaldehyde;

[0034] 3) Add 5 mL of freshly distilled pyrrole propionic acid solution dropwise to the mixed solution treated in step 2), and stir and reflux for 1 hour; ...

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Abstract

The invention provides a novel compound for detecting hexanal exhaled by a lung cancer patient and a preparation method thereof. The structural formula is represented as follows. The compound is called as bis-[5-(4-carbonyl phenyl)-10, 15, 20-triphenyl porphyrin]-1, 2-phthalimide. The compound is obtained by removing two molecules of water from 5-p-carboxyphenyl-10, 15, 20-triphenyl porphyrin and o-phenylenediamine; carboxyl porphyrin with excellent photoelectric properties and the o-phenylenediamine are subjected to condensation reaction to form a molecular tweezer compound with specific cavity sizes; and the compound can be further developed into a sensitive material for visual breath detection of the lung cancer patient. By means of the novel compound, breathing diagnosis of diseases can be performed, and problems that convention diagnosis methods of lung cancers are complicated, time-consuming and expensive and can cause damages to the patient are solved.

Description

Technical field [0001] The present invention involves a new type of compound that specializes in lung cancer to exhale gas. [0002] Background technique [0003] Lung cancer refers to the malignant epithelial tumor of the lungs. It originated from bronchial epithelium, bronchial mucus glands, fine -sized bronchododes and alveolar epithelium.At present, the incidence and mortality of lung cancer are ranked first in various malignant tumors.The incidence and mortality of lung cancer in my country have always been on the rise, and about 600,000 people die each year from lung cancer.Clinically, the common diagnostic methods of lung cancer are the following: X -ray examination, electronic computer fault scanning, magnetic resonance fault scanning, sputum shedding cell examination, fibrous bronchoscope examination, and leather lung puncture biopsy.The above -mentioned routine diagnosis methods of lung cancer are expensive and expensive, and it will also cause damage to patients, so it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22G01N21/25
Inventor 侯长军吴宇法焕宝霍丹群杨眉钟先华
Owner CHONGQING UNIV
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