Cellulose and red alga polysaccharide plant empty capsule and raw material composition and preparation method thereof
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A plant hollow capsule and raw material composition technology, applied in the direction of capsule transportation, can solve the problems of difficulty in realizing industrialization, affecting the disintegration time limit, easy to exceed the standard of microorganisms, etc., to ensure long-term stability, simple process, no cross-linking reaction. Effect
Inactive Publication Date: 2013-01-30
GUANGXI NANNING HUIRUN BIO TECH
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Problems solved by technology
The plant capsules are all made of plant raw materials, do not need constant temperature storage, will not spread foot-and-mouth disease and mad cow disease, are not easy to pollute, meet the requirements of vegetarian culture, and are suitable for storage and transportation of aldehyde-containing drugs, but the disintegration time limit is affected by potassium salts , the added protein makes it easy for microorganisms to exceed the standard and not easy to store
[0012] There are many shortcomings in the above patented technology itself, and it is difficult to realize industrialization
Method used
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Embodiment 1
[0056] Ingredients weighing
[0057] Weigh 95 kg of raw material component A (hypromellose), 4 kg of red algal polysaccharide (3 kg of K-carrageenan, 1 kg of ι-carrageenan), and 1 kg of alcohols (glycerol) by weight; Mix component A and red algae polysaccharide with a two-dimensional mixer for 6 hours until uniform, and set aside;
[0058] Sol color matching
[0059] Add purified water 5 times the weight of raw materials into the sol tank, raise the temperature to 90°C, add the uniformly mixed materials in step , stir until completely dissolved, then add alcohol, cool down to 40°C to form a glue;
[0060] glue insulation
[0061] The glue formed in step was incubated at 45°C for 6 hours;
[0062] capsule making
[0063] The glue solution in step is dipped in glue, formed, dried, stripped, cut, and fitted on a fully automatic capsule production line to obtain the semi-finished capsule shell of the cellulose red algae polysaccharide plant hollow capsule; wherein, the v...
Embodiment 2
[0075] Raw material component A (hypromellose) 88 kg, red algae polysaccharide 11 kg (K-carrageenan 10 kg, ι-carrageenan 1 kg), alcohol (glycerol) 1 kg, other processes and equipment and Embodiment 1 is basically the same.
Embodiment 3
[0077] Raw material component A (hypromellose) 93.7 kg, red algae polysaccharide 5.3 kg (K-carrageenan 4.3 kg, ι-carrageenan 1 kg), alcohol (glycerol) 1 kg, other processes and equipment and Embodiment 1 is basically the same.
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Abstract
The invention discloses a raw material composition of a cellulose and red alga polysaccharide plant empty capsule. The raw material composition of the cellulose and red alga polysaccharide plant empty capsule comprises the following raw materials in parts by weight: 77.5-98.5 parts of component A, 1.5-22.5 parts of red alga polysaccharide and 0.5-12.5 parts of alcohol, wherein the component A is a cellulose derivative or resin. The invention also discloses the cellulose and red alga polysaccharide plant empty capsule prepared from the raw material composition and a preparation method for the cellulose and red alga polysaccharide plant empty capsule. The plant empty capsule does not deform or crisp in an environment of high temperature, high humidity or cold, is low in moisture content and high in stability, and can be conveniently stored for a long time. Moreover, the requirements on the storage condition are low. Meanwhile, the plant empty capsule is stable in chemical property and has no cross-linking reaction or Maillard reaction or condensation reaction. Various physicochemical indexes of the plant empty capsule, such as disintegration time limit, completely accord with the specifications of the Chinese pharmacopoeia or national standard, and therefore, all defects and potential safety hazards of a gelatin capsule are completely eliminated. The industrial production of the cellulose and red alga polysaccharide plant empty capsule can be realized.
Description
technical field [0001] The invention relates to a film-forming material for capsules, in particular to a cellulose red algae polysaccharide plant hollow capsule, a raw material composition and a preparation method thereof. Background technique [0002] Hard hollow capsules have been used as drug carriers for a long time, and they generally use gelatin as a raw material. The capsule material of gelatin hollow capsule is gelatin, which is purified by hydrolysis of pig or cow skin and bone. Its chemical essence is animal collagen and amino acids. The defects of physical and chemical properties lead to gelatin's poor compatibility with many drugs and short shelf life. . Because animal collagen and amino acids are easy to cross-link with drugs with amino groups in their chemical structure and macrolide antibiotics to form a dense network structure, making it difficult for drug capsules to disintegrate or dissolve, reducing the human bioavailability of drugs It can also have Mai...
Claims
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Application Information
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