Long-acting donepezil percutaneous absorption sticking agent
A technology of donepezil and absorption enhancer, which is applied in the field of medicine to achieve long-lasting curative effect, long-lasting and stable curative effect, and improved percutaneous penetration
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[0024] Example 1
[0025] 0.25g donepezil free base, 0.0125g Lecithin, 0.0125g Propylene glycol was dissolved in 3.0g ethyl acetate, and then added 4.725g DuroTak® 87-9301, a pressure-sensitive adhesive from National Starch Company, mixed evenly with magnetic stirring for 2 hours, coated on a 75μm thick release layer, dried at 20℃, 40℃, and 80℃, and then used a backing with a thickness of 75μm~85μm Layer polyethylene composite, prepared into an area of 60cm 2 Pressure-sensitive adhesive dispersion patch.
Example Embodiment
[0026] Example 2
[0027] Dissolve 0.5g donepezil free base, 0.125g lecithin, and 0.125g propylene glycol in 3.0g ethyl acetate, then add 4.5g National Starch pressure-sensitive adhesive DuroTak 87-9301, magnetically stir for 2h and mix evenly, and apply on 75μm The thick release layer is dried at 20°C, 40°C, and 80°C, and then compounded with a backing layer polyethylene with a thickness of 75μm~85μm to prepare an area of 60cm 2 Pressure-sensitive adhesive dispersion patch.
Example Embodiment
[0028] Example 3
[0029] 0.75g donepezil free base, 0. 25g Lecithin, 0. 25g Propylene glycol was dissolved in 3.0g ethyl acetate, and then added 3.75g DuroTak® 87-9301, a pressure-sensitive adhesive from National Starch Company, mixed evenly with magnetic stirring for 2 hours, coated on a 75μm thick release layer, dried at 20℃, 40℃, and 80℃, and then used a backing with a thickness of 75μm~85μm Layer polyethylene composite, prepared into an area of 60cm 2 Pressure-sensitive adhesive dispersion patch.
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