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Partially absorbable fibrous membrane hernia mesh

A fibrous membrane and hernia technology, applied in medical science, textiles, papermaking, prosthesis, etc., can solve the problems of unfavorable tissue remodeling, narrow source, non-absorbable, etc., and achieve good biocompatibility and tissue compatibility, The effect of excellent finished product performance and excellent mechanical strength

Active Publication Date: 2015-12-16
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-absorbable synthetic mesh is the representative of permanent hernia mesh. However, there are many potential postoperative risks due to chronic allograft rejection during use, such as effusion and adhesion formation, and the risk of inflammatory response at the infection site High, in addition, it is not conducive to the flexibility and recovery of the abdominal wall in a large range of motion in situ
Currently applicable artificial absorbable patches, such as polyglycol ester and polylactate, are often not conducive to the remodeling of the defect site due to their fast degradation rate, thus failing to achieve the desired effect
Due to the narrow source of biological tissue extracts, the use process has great limitations. In addition, when it comes to animal and human extracts, it is often involved in religious and belief issues, which also limits its application prospects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Partially absorbable fibrous membrane hernia mesh as follows:

[0022] (1) Solution preparation: PVDF (molecular weight 300,000) and PLGA (molecular weight 50,000) are dissolved in a mixed solvent of DMF and acetone (volume ratio is 5:5) to obtain an electrospinning solution with a concentration of 15wt%, wherein PVDF The mass ratio to PLGA is 95:5;

[0023] (2) Electrospinning: the solution obtained by (1) is placed in the feed injector of the multi-spinneret electrospinning machine, and the distance between the spinneret and the roller is adjusted to be 12cm; the ambient temperature of spinning is At 25°C, the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; Turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 20KV, the feeding speed of the solution is 20 μl / min, and obtain the electrospun fiber composite film on the rotating drum;

[0024] (3) After washing the fibrous membrane collected in (2) repeatedly with de...

Embodiment 2

[0026] Partially absorbable fibrous membrane hernia mesh as follows:

[0027] (1) Preparation of solution: PVDF (molecular weight 200000) and PLGA (molecular weight 400000) are dissolved in the mixed solvent of DMF and acetone (volume ratio is 5: 5) respectively, obtain PVDF concentration and be 25wt% and PLGA concentration be 12wt% electrospinning solution;

[0028] (2) Electrospinning: the solution obtained in (1) is placed in the feed injector of the multi-spinneret electrospinning machine, and the ratio of the number of spinnerets is adjusted to PVDF:PLGA=8:2, two feeders The feeding rate ratio of the injector is adjusted to be PVDF:PLGA=3:2, and the distance between the spinneret and the roller is adjusted to be 12cm; the ambient temperature of spinning is 25°C, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; Turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 20KV, the feeding speed of the solution is 20 μl / ...

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PUM

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Abstract

The invention relates to a fibrous membrane hernia patch capable of being absorbed partially. The patch is obtained by adding proper PLGA into non-degradative polyvinylidene fluoride (PVDF) as a main body raw material and conducting electrostatic spinning blending or cospinning. The diameter of the fiber membrane is 1mum to 5 mum, and the thickness of the fiber membrane patch is 60mum to 500 mum. The PVDF serves as the main body material and can maintain stability of physical and chemical performance. Simultaneously, the patch can be widely applied to various primary and recurrent hernia repair technologies due to the fact that addition of the PLGA improves compatibility of materials at implantation front stage.

Description

Technical field: [0001] The invention relates to the field of degradable polymer materials and composite materials, in particular to a partially absorbable fiber membrane hernia patch. Background technique: [0002] The introduction of polymer mesh structure in hernia mesh suturing surgery has been proven to reduce the recurrence rate and pain, thereby improving the healing effect of patients. So far, many synthetic artificially prepared mesh structures have been designed and used in hernia repair surgery. But so far, there is no mesh structure that can remodel the regeneration of the host structure and have high strength to repair the defect of the abdominal wall. [0003] The current hernia treatment method is mainly implanted hernia mesh material. The existing hernia meshes are divided into three categories: non-absorbable synthetic mesh, in vivo absorbable artificial mesh mesh, and biological tissue extraction engineering scaffolds. Non-absorbable synthetic mesh is th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/26A61L27/18A61L27/16D04H1/728D04H1/4382
Inventor 韩志超许杉杉
Owner TRANSEASY MEDICAL TECH