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Licoflavone phospholipid complex and preparation method and application thereof

A technology of licorice flavonoids phospholipids and licorice flavonoids is applied in directions such as drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as difficult absorption, and achieve the effects of enhancing antioxidant properties, simple preparation process, and enhancing solubility and stability.

Inactive Publication Date: 2013-03-06
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiencies of the prior art, to provide a simple preparation process, good reproducibility, through the phospholipid embedding of licorice flavonoids, to improve the hydrophilic and lipophilic physical and chemical properties of licorice flavonoids, improve the solubility of licorice flavonoids , improve its bioavailability, can effectively solve the problem that it is not easily absorbed, and maintain or enhance its antioxidant properties in different environments. A preparation method and application of a licorice flavonoid phospholipid complex

Method used

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  • Licoflavone phospholipid complex and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Licorice flavonoid phospholipid complex (drug: lipid = 6:1)

[0029] Weigh 800 mg of licorice flavonoids and 200 mg of soybean lecithin, put them in a conical flask, add 80 ml of ethanol, stir in a water bath at 30°C for 3 hours to form a transparent dark brown solution, drain the organic solvent under reduced pressure, add an appropriate amount of chloroform, and make the solution Clarify, shake fully, filter to remove the precipitate, and dry the filtrate to obtain the licorice flavonoid phospholipid complex.

Embodiment 2

[0031] Licorice Flavonoid Phospholipid Complex

[0032] Weigh 600mg of licorice flavonoids and 400mg of soybean lecithin, put them in a conical flask, add 60ml of ethanol, stir in a water bath at 30°C for 4 hours, and form a transparent dark brown solution, drain the organic solvent under reduced pressure, add an appropriate amount of chloroform, and make the solution Clarify, shake fully, filter to remove the precipitate, and dry the filtrate to obtain the licorice flavonoid phospholipid complex.

Embodiment 3

[0034] Licorice Flavonoid Phospholipid Complex

[0035] Weigh 400mg of licorice flavonoids and 600mg of soybean lecithin, put them in a conical flask, add 40ml of ethanol, stir in a water bath at 30°C for 1.5h to form a transparent brown-yellow solution, drain the organic solvent under reduced pressure, add an appropriate amount of ethyl acetate, Shake well, filter to remove the precipitate, and dry the filtrate to obtain the licorice flavonoid phospholipid complex.

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Abstract

The invention relates to a preparation method of a complex, in particular to a licoflavone phospholipid complex and a preparation method and the application of the licoflavone phospholipid complex; the licoflavone phospholipid complex comprises licoflavone and phospholipid by mass ratio of 1: 0.1-10; and the method comprises the steps of: according to the proportion, adding the licoflavone and the phospholipid into organic solvent, controlling the temperature to be within the range of 10-90 DEG C and carrying out reaction for 20min-8h until the reaction liquid is clear; carrying out pressure reduction or freeze drying to remove the organic solvent; after that, adding inert solvent to separate free drug which is not compounded; and removing the inert solvent and drying to obtain the licoflavone phospholipid complex. The invention is simple in preparation technology and good in reproducibility, and can improves the physicochemical properties including hydrophilic property and oleophylic property of the licoflavone by embedding the licoflavone by the phospholipid, so that the dissolving property of the licoflavone can be improved, the bioavailability of the licoflavone is increased, the problem that the licoflavone is not easily absorbed can be solved, the oxidation resistance of the licoflavone in different environments can be maintained or enhanced.

Description

technical field [0001] The invention relates to a preparation method of the compound, in particular to a licorice flavonoid phospholipid compound and its preparation method and application. Background technique [0002] Licorice root is a kind of Chinese herbal medicine with a wide range of uses. It can not only reconcile various medicines, but also invigorate qi and neutralize it, relieve fire and detoxify, and strengthen bones and muscles. It has the functions of anti-ulcer, anti-inflammation, lowering blood pressure, lowering blood fat, central nervous system inhibition and even anti-tumor. [0003] Licorice mainly contains triterpenoids, flavonoids and polysaccharides. Since the 1960s, it has been found that flavonoids in licorice plants have anti-inflammatory, antiviral, cardiotonic, sedative and analgesic effects. Later, it was found that they have anti-oxidation, anti-aging, anti-tumor and other effects. Especially in recent years, it has also been found that flavon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P9/06A61P31/18A61P35/00
Inventor 张霞张文华侯延辉张立明徐力生
Owner NINGXIA MEDICAL UNIV
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