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Biosensor

A biosensor and substrate technology, applied in the field of biosensors, can solve problems such as limited oxygen solubility, impact on test results, and impact on detection limits, and achieve the effects of improving accuracy and reliability, reducing interference factors, and improving accuracy

Inactive Publication Date: 2013-03-06
崔刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first-generation glucose oxidase sensor has the following disadvantages: ①The change of dissolved oxygen may affect the fluctuation of the electrode response; ②The solubility of oxygen is limited. When the dissolved oxygen is poor, the corresponding current drops significantly, thus affecting the detection limit; ③Biosensor The response performance of the solution is greatly affected by the pH and temperature of the solution
In addition, factors that affect blood sugar measurement blood glucose test strips include hematocrit, too high or too low hematocrit (with Hct 42% as the benchmark) will affect the test results
In addition, the blood glucose test strip code input error; the current blood glucose meter test strip code technology is a manual barcode technology, which requires manual input of the code on the blood glucose test strip, which is prone to human input code errors
The other is the code chip technology, which does not require manual input; however, the code chip must be replaced every time a box of test strips is changed. Generally speaking, the latter is more convenient; but there are also mistakes; but the frequency is relatively less

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0067] Embodiment 1, do not contain the reagent composition of sulfonic acid group hydrocarbon compound

[0068] Hexaammine ruthenium trichloride 5.0g (weight ratio is 40%), polyvinyl alcohol 1.0g (weight ratio 8.0%) Triton X-1000.5g (weight ratio 4.0%), glucose oxidase 6.0g (weight ratio 48.0%) ) was dissolved in 100ml of phosphate buffered saline solution with a pH of 6.4 and filtered.

Embodiment 2

[0069] Embodiment 2, the reagent composition that contains potassium ferricyanide and sulfonic acid hydrocarbon compound

[0070] Potassium ferricyanide 5.0g (weight ratio is 37.0%), sodium octyl sulfonate 1.0g (weight ratio 17.4%) polyvinyl alcohol 1.0g (weight ratio 7.4%), Triton X-1000.5g (weight ratio 3.7%) , Glucose oxidase 6.0g (44.5% by weight) The above compound was dissolved in 100ml of phosphate buffered saline solution with a pH of 6.4, and filtered.

Embodiment 3

[0071] Embodiment 3, the reagent composition that contains hexammine ruthenium trichloride and sulfonic acid hydrocarbon compound

[0072] Hexaammine ruthenium trichloride 5.0g (weight ratio is 37.0%), sodium octylsulfonate 1.0g (weight ratio 7.4%) polyvinyl alcohol 1.0g (weight ratio 7.4%), Triton X-100 0.5g (weight ratio ratio 3.7%), glucose oxidase 6.0g (weight ratio 44.5%), the above compound was dissolved in 100ml of phosphate buffered saline solution with a pH of 6.4, and filtered.

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PUM

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Abstract

The invention provides a biosensor. The biosensor is used for detection of biological substances. The biosensor comprises 1, an electrode system having a complex stereochemical structure, 2, a reagent composition for corresponding biological substance detection and 3, a combined switch system for automatical identification of correcting codes. After being automatically sucked into the electrode system, a detected sample undergoes a biochemical reaction and an electrochemical reaction with the reagent composition to produce electrons; the electrons are transmitted to a tester by an electrode; the tester reads data and the data is processed; and a detection result is displayed. The combined switch system for automatical identification of correcting codes solves the problem of inconvenience of manual inputting of relevant information, avoids detection result errors produced by input errors, and has high production efficiency and a low cost.

Description

technical field [0001] The invention relates to a biosensor. Background technique [0002] Glucose oxidase (glucose oxidase, GOD) was discovered by Muller in 1928. Since then, Nekamatsu, Konelia, Yoshio, etc. have done a lot of research on it and put it into production. Fiedurek and Rogalski have done a lot to increase the enzyme unit. research work, especially the prosthetic group of glucose oxidase - flavin adenine dinucleotide (FAD) has done an in-depth study, and gave a detailed description, the enzyme is currently widely used in clinical testing and food industry use. The glucose sensor uses the specificity of glucose oxidase to catalyze the oxidation of glucose to detect the glucose content in various substances. The glucose sensor has extremely important application value in biology and medicine. In 1962, Clark and Lyons proposed combining an enzyme with an electrode to measure the glucose content by detecting the oxygen consumed by the enzyme-catalyzed reaction. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416
Inventor 不公告发明人
Owner 崔刚
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