Ball-milling coupling extraction integrated process for strengthening natural plant active ingredient extraction

An active ingredient and process technology, which is applied in the integrated process field of ball milling coupled leaching to strengthen the extraction of natural active ingredients of plants, can solve the problem that the process needs to be further improved, and achieve the effects of strong free radical scavenging ability, convenient operation and improved extraction rate.

Inactive Publication Date: 2013-03-13
INST OF PROCESS ENG CHINESE ACAD OF SCI
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AI Technical Summary

Problems solved by technology

Li Xiaohong, Sun Jing (2012) carried out the exploration of extracting baicalin from Scutellaria baicalensis and gin

Method used

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  • Ball-milling coupling extraction integrated process for strengthening natural plant active ingredient extraction

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Extraction Technology of Grape Skin Polyphenols by Ball Milling Method

[0028] Crush the grape pomace through a 40-mesh sieve, select the TJ-1 type particle ball mill, and then put it and the balls in a certain ratio (mass (g) / number) of 1:4, and place them in a ball mill made of zirconia. , the balls are zirconia balls, rotate ball mill at 1000rpm for 30min, then extract with 60% ethanol in 70℃ constant temperature water bath for 30min according to 1:10 solid-liquid ratio, centrifuge to get the supernatant, concentrate and dry to form the finished product. After concentrating under reduced pressure, the obtained ethanol is recycled for reuse. Using the Prussian blue method and using catechol as the standard, the polyphenols in grape skin were measured to be 17.90% higher than that of crushed grape pomace after leaching in a water bath at 70°C for 30 minutes. After removing DPPH free radicals and OH - Free radicals, O 2- Anti-oxidation experiments such as can be obta...

Embodiment 2

[0030] Ball Milling Extraction Technology of Scutellaria baicalensis

[0031] Crush Scutellaria baicalensis through a 20-mesh sieve, use a double planetary ball mill, put the material and the balls in a certain ratio (mass (g) / number) of 1:6, put them in an agate ball mill jar, use agate balls, and grind them at 1200rpm After rotating ball milling for 30 minutes, the obtained powder was leached with 65% ethanol in a constant temperature water bath at 70°C according to a ratio of 1:14 to liquid, centrifuged at 4000 rpm for 15 minutes after 60 minutes, and the supernatant was taken, concentrated and dried to form a finished product. After concentration under reduced pressure, the obtained ethanol is recovered and reused. Using sodium nitrite and aluminum nitrate colorimetric method, with rutin as the standard product, the content of baicalin flavonoids after ball milling was measured to increase by 21.97%, after removing DPPH free radicals, OH- free radicals, O 2- It can be obt...

Embodiment 3

[0033] Ball Milling Extraction Technology of Scutellaria Baicalensis Polysaccharides

[0034] 2. Scutellaria baicalensis processed products are crushed through a 20-mesh sieve, and an all-round planetary ball mill is selected, and then the material and the balls are placed in a stainless steel ball mill tank according to a certain ratio (mass (g) / number) of 1:2. , after ball milling at 1000rpm for 60min, weigh 2g of Scutellaria baicalensis processed product into a round bottom flask, add 40mL of water to extract at 70°C for 2h, filter, and take the supernatant. After alcohol precipitation, crude polysaccharides are obtained. Using the phenol-sulfuric acid method, with glucose as the standard product, the polysaccharide content of processed Scutellaria baicalensis after ball milling was measured to be 15.97% higher than that directly crushed and extracted. After removing DPPH free radicals, OH- free radicals, O 2- Anti-oxidation experiments show that the obtained polysaccharid...

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Abstract

The invention discloses a ball-milling coupling extraction integrated process for strengthening natural plant active ingredient extraction. The process mainly includes the steps of: 1. raw material cleaning and drying; 2. raw material coarse grinding; 3. ball-milling grinding; 4. extraction; 5. centrifugation; and 6. concentration and drying. The invention adopts a particle ball-milling grinder to grind natural plants, and the rotation speed, time and ball particle number are set according to different materials. Ball-milling tends to micronize material particles, promote the release of effective active ingredients, and substantially improves the extraction rate of natural products. The products obtained by the invention are crude natural products, which can be further purified so as to be used in medicines, health care products and the like according to different uses. The natural plant effective active ingredients involved in the invention mainly refer to polyphenol materials, polysaccharides, quinones and saponins, etc.

Description

technical field [0001] The invention belongs to the technical field of extraction of natural active ingredients of plants, and can be used for the extraction of effective active ingredients in leftovers such as fruit shells and peels in the food industry chain, and particularly relates to an integrated process for extracting natural active ingredients of plants coupled with ball milling . Background technique [0002] In recent years, with the gradual deepening of people's understanding of the medicinal and nutritional value of active ingredients in plant natural products, there has been an upsurge of research on active ingredients in natural products worldwide, and the National Natural Science Foundation of China has given a lot of research in this direction. item funding. However, the composition of natural products is very complex, and some active ingredients have very little content. How to extract high-active ingredients more efficiently and at low cost has become one ...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/87A61K36/539A23L1/29A61P39/06A23L33/00
Inventor 徐建高婧彭华栋
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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