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Application of silicon dioxide aerogel in pharmacy

A technology of silica and airgel, applied in the fields of silica, silicon oxide, inorganic chemistry, etc., can solve the problems of nano-drug loading systems that have not yet been discovered

Active Publication Date: 2013-03-13
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is precisely because of these characteristics that silica airgel materials have attracted widespread attention in the fields of thermal insulation, biosensors, catalysis and optical materials, but so far, no silica airgel materials have been found as nano Precedents of drug delivery system application in pharmaceutical field

Method used

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  • Application of silicon dioxide aerogel in pharmacy
  • Application of silicon dioxide aerogel in pharmacy
  • Application of silicon dioxide aerogel in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Preparation of paclitaxel nanoparticles:

[0117] 1. Paclitaxel API (Yunnan Hande Pharmaceutical Co., Ltd.) 1g, add 20ml of absolute ethanol to dissolve;

[0118] 2. Add silica airgel after heat treatment at 300°C (porosity 95%, pore diameter 10nm, specific surface area 1000m 2 / g, the density is 300kg / m 3 , The diameter of the colloidal particles that make up the network is 20nm) 2g for adsorption;

[0119] 3. After the adsorption is complete, dry it in an oven at 60°C;

[0120] 4. After drying, add 100ml of pure water and emulsify with 25000rpm / min ordinary emulsifier for 5min;

[0121] 5. High-pressure homogenizer (Shanghai Donghua GYB30-6S), 400bar, cycle 6 times, 10min;

[0122] 6. Spray-dry the homogeneous liquid in an experimental spray dryer (Shanghai Shunyi Technology SP-1500), parameters: temperature 130°C, flow rate 500ml / H, nozzle: 0.75mm, and obtain paclitaxel nanoparticles after drying.

Embodiment 2

[0124] Preparation of paclitaxel nanoparticles:

[0125] 1. Paclitaxel API (Yunnan Hande Pharmaceutical Co., Ltd.) 1g, add 100ml of absolute ethanol to dissolve;

[0126] 2. Add hydrophilic silica airgel (porosity 97%, pore diameter 16nm, specific surface area 500m 2 / g, the density is 150kg / m 3 , The diameter of the colloidal particles that make up the network is 50nm) 10g for adsorption;

[0127] 3. After the adsorption is complete, freeze-dry;

[0128] 4. After drying, add 110ml of pure water and emulsify with 25000rpm / min ordinary emulsifier for 5min;

[0129] 5. High-pressure homogenizer (Shanghai Donghua GYB30-6S), 400bar, cycle 7 times, 10min;

[0130] 6. Spray-dry the homogeneous liquid in an experimental spray dryer (Shanghai Shunyi Technology SP-1500), parameters: temperature 130°C, flow rate 500ml / H, nozzle: 0.75mm, and obtain paclitaxel nanoparticles after drying.

Embodiment 3

[0132] Preparation of insulin nanoparticles:

[0133] 1. Add 150ml of 0.01mol / L AR grade hydrochloric acid to dissolve 1g of insulin raw material (Jiangsu Wanbang Biochemical Pharmaceutical Co., Ltd.);

[0134] 2. Add silica airgel after heat treatment at 1000℃ (porosity is 99%, pore diameter is 50nm, specific surface area is 500m 2 / g, the density is 3kg / m 3 , The diameter of the colloidal particles that make up the network is 1nm) 15g for adsorption;

[0135] 3. After complete adsorption, dry with a freeze dryer for 4 hours;

[0136]4. Add another 10g of PEG-600 to 1000ml of absolute ethanol to dissolve;

[0137] 5. Add the lyophilized solid in step 3 into the above ethanol solution of PEG-600, and emulsify with a ultrasonic emulsifier for 3 minutes;

[0138] 6. Dry the emulsion in step 5 in a 60°C electric constant temperature drying oven for 12 hours;

[0139] 7. Grinding the dried solid in step 6, and passing through a 200-mesh sieve to obtain insulin nanoparticles. ...

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Abstract

The invention discloses application of silicon dioxide aerogel in pharmacy, relates to application of the silicon dioxide aerogel, and in particular relates to application of silicon dioxide aerogel used as a nanoparticle medicine carrying system in the pharmacy. A new pharmaceutic adjuvant is searched in the field of pharmacy, and is not a nanoparticle material or nano-powder which is fashionably used in the present day, so that a medicine carrying hollow new structure is truly realized, the physical medicine carrying scale below 100 nanometers that any one of the adjuvants in the modern pharmaceutic adjuvant cannot realize is achieved, and the blank of the nanoscale pharmaceutic adjuvant in the international countries or the domestic countries is made up.

Description

technical field [0001] The invention relates to the use of silicon dioxide airgel, in particular to the application of silicon dioxide airgel as a nano drug loading system in pharmacy. Background technique [0002] With the widespread application of combinatorial chemistry and high-throughput screening technologies in the development of new drugs, the development of new compound entities is getting faster and faster. However, according to statistics, among many new physiologically active compound entities, there are more and more hydrophobic compounds, accounting for about 40%, while chemically synthesized candidate compounds are as high as 60%. It is worth mentioning that during the development phase, as many as 40% to 70% of them cannot produce sufficient efficacy due to insufficient solubility. In this way, the current research and development of new drugs presents the characteristics of long cycle, large investment and high risk. If many candidate compounds are difficu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K9/06A61K9/10A61P35/00A61K33/243
CPCA61K9/00C01B33/14A61K9/143A61K9/2077A61K9/5115A61K31/337A61K38/28A61K31/704A61K31/7068A61K31/675C01B33/1585A61P35/00A61K33/243A61K9/0053A61K9/06A61K9/485C01P2006/10C01P2006/12C01P2006/16
Inventor 张旭旭康飞宇
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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