Method for simply and effectively removing 2-position methyl and 6-position methyl of 2, 6-dimethyl-4-pyridinone derivative

A technology of pyridone and derivatives, applied in the field of removal of 2, can solve the problems of high reaction temperature, strong alkali, strong acid, etc., and achieve the effect of low volatility, few experimental steps and high chemical selectivity
CN102964299AInactive Publication Date: 2013-03-13HENAN NORMAL UNIV
4 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HENAN NORMAL UNIV
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention provides a method for simply and effectively removing 2-position methyl and 6-position methyl of a 2, 6-dimethyl-4-pyridinone derivative. The method comprises the step of removing two methyl groups in Alpha-position of the 2, 6-dimethyl-4-pyridinone derivative under a heating condition by adopting oxygen as an oxidant and ferric chloride anhydrous as a catalyst. The 2, 6-dedimethylation-pyridinone derivative can be simply obtained along with high yield by the processes of cooling, extracting and separating after the reaction. According to the method, the reaction is just carried out in one step, so that the process is simple; the raw materials and the catalyst are the chemistry and chemical raw materials which are low in price and easy to obtain; and the organic solvent in reaction is easily recovered and recycled, so that the whole reaction is a clean and efficient technological process, and the benefit is provided for massive industrial production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the selective removal of 2,6-dimethyl-4-pyridone derivatives of the 2- and 6-methyl method, specifically using oxygen as an oxidant and anhydrous ferric chloride as a catalyst, using DMF is used as a solvent to remove the 2- and 6-methyl groups of 2,6-dimethyl-4-pyridone derivatives. The method has the advantages of environmental friendliness, good compatibility of important functional groups, and good regioselectivity. Background technique

[0002] 4-Pyridone derivatives have diverse biological activities and are widely used in chemical and chemical fields such as medicine and pesticides. Their biological activities are mainly reflected in antitumor, antiviral, antibacterial, antiedema, antipsychotic, Met kinase inhibitor, etc. At the same time, they are also a very important class of organic synthesis intermediates. At present, there are a large number of referenced literatures reporting the synthesis methods of py...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More