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Preparation method for anisic aldehyde-modified sodium alginate and gel microspheres thereof

A technology of sodium alginate and anisaldehyde, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as immeasurable application prospects, and achieve easy control and synthesis process Simple, the effect of increasing the load factor

Inactive Publication Date: 2013-03-20
孙寂呐
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If sodium alginate is hydrophobically modified to improve drug loading and sustained release performance, its application prospects are immeasurable

Method used

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  • Preparation method for anisic aldehyde-modified sodium alginate and gel microspheres thereof
  • Preparation method for anisic aldehyde-modified sodium alginate and gel microspheres thereof
  • Preparation method for anisic aldehyde-modified sodium alginate and gel microspheres thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0020] In a 100ml three-necked flask, prepare 50ml of 2% w / v sodium alginate solution, add 4ml of anisaldehyde to dissolve in 40ml of absolute ethanol, and then pour the solution into the three-necked flask. After sealing, stir electrically until the solution is evenly mixed, then add 2% hydrochloric acid of the monomer mass to catalyze, and carry out two groups of reactions at T=40°C (Scheme I) and 60°C (Scheme II), and the reaction time is 10h. After the reaction, it was precipitated with methanol, finally dissolved in distilled water, dialyzed for 3 days, and freeze-dried to obtain hydrophobically modified sodium alginate.

[0021] The occurrence of sodium alginate modification reaction was proved by infrared spectrum. In the infrared spectrum ( figure 2 ), 1258cm -1 is the absorption peak of the C-O ether bond, which indicates that the acetalization reaction between sodium alginate and anisaldehyde occurred.

[0022] Fluorescence spectrum ( image 3 ) in I 1 and I 3...

Embodiment approach 2

[0024] Weigh 0.2g of the samples of sodium alginate (alg), scheme I, and scheme II respectively, dissolve it in 10ml of distilled water to obtain a 2% w / v solution, and adjust the pH value of the configured solution to a weak Acidity (in order to compare with sodium alginate), then add 0.02g of the drug bovine serum albumin to be loaded respectively. After fully mixing, under slow stirring with a magnetic stirrer, the solution was slowly dripped into 50ml of CaCl with a mass fraction of 2% using a medical syringe (needle inner diameter 0.45mm). 2 In the solution, continue to solidify for half an hour after the dropwise addition, filter with Buchner funnel, rinse with deionized water three times, and dry the obtained sample at low temperature. Then the in vitro simulated release test was carried out. The gel microspheres prepared by scheme I and scheme II have an embedding rate of 68.3% and 77.93% respectively for the drug bovine serum albumin, while the embedding rate of the ...

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Abstract

Hydrophobically modified sodium alginate is obtained via acetalation reaction of sodium alginate with p-anisaldehyde (also called anisic aldehyde) in acid-catalyzed condition, and is prepared to be gel. Analysis of the product is performed by using fluorescence, transmission electron microscopy, scanning electron microscopy, UV, and thermal analysis, and analysis results shows that the anisic aldehyde successfully reacts with the sodium alginate. The gel can be used as a drug carrier for embedding and releasing bovine serum albumin, and results shows that drug loading ratio and releasing performance of the modified product are improved by some extent compared with the unmodified sodium alginate. The product of the present invention can be used as a drug carrier material to apply in the medical field.

Description

technical field [0001] The invention relates to preparing gel microspheres by modifying sodium alginate with anisaldehyde, which belongs to the technical field of biomedical materials. Background technique [0002] Sodium alginate (Sodium Alginate, referred to as SA) is a polysaccharide carbohydrate extracted from brown algae kelp or sargassum, and is the main component of seaweed cell wall and intercellular substance. A linear polymer composed of mannuronic acid (referred to as M) and α-L-guluronic acid (referred to as: G), is one of the alginic acid derivatives, so it is sometimes called sodium alginate or sodium alginate. Kelp gum and alginate, its molecular formula is (C 6 h 7 0 6 Na)n, the molecular weight of its structural unit is 198.1, and the relative molecular weight is between 32,000 and 200,000. It can form simple gels with multivalent cations under mild gelation conditions. Because of its unique physical and chemical properties and good biocompatibility, it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04C08J3/24C08J3/075A61K47/36A61K38/38A61K9/06
Inventor 倪才华吴敏陶蕾田志强夏凤愉刘小琴高玲
Owner 孙寂呐
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