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Blood nourishing and brain arousing particle quality detection method

A quality detection method, the technology of Yangxue Xuenao Granules, applied in the field of medicine

Active Publication Date: 2013-03-27
天士力东北现代中药资源有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a quality detection method of Yangxue Xuenao Granules, which solves some important technical problems in current detection

Method used

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  • Blood nourishing and brain arousing particle quality detection method
  • Blood nourishing and brain arousing particle quality detection method
  • Blood nourishing and brain arousing particle quality detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Identification of Prunella vulgaris (ursolic acid)

[0097] Preparation of the test solution: Take 1 g of this product, add 0.5 ml of dilute hydrochloric acid and 20 ml of ether, heat to reflux for 30 minutes, evaporate the ether to the fullest extent of the extract, add 0.5 ml of methanol to dissolve the residue, and use it as the test solution.

[0098] Preparation of reference substance solution: take ursolic acid reference substance, add methanol to make a solution containing 0.1mg per 1ml, as the reference substance solution.

[0099] The choice of developer: prepare cyclohexane-ethyl acetate-chloroform-glacial acetic acid in the ratio of 20:3:7:0.2, 15:2:5:0.1, and 25:4:9:0.5, respectively. agent.

[0100] According to the thin-layer chromatography test, draw 10 μl of the test solution and 5 μl of the reference solution, respectively spot on the same silica gel G thin-layer plate, develop under the above developer conditions, take it out, dry it, and spray it wit...

Embodiment 2

[0102] Corydalis identification

[0103] Preparation of the test solution: Take 1 g of this product, put it in a centrifuge tube with a plug, add 4 ml of 0.2 mol / L sodium hydroxide solution, shake to dissolve, add 5 ml of ethyl acetate, shake fully, centrifuge for 2 minutes, take The upper layer solution was evaporated to dryness, and the residue was dissolved in 1ml of methanol as the test solution.

[0104] Preparation of the reference medicinal material solution: 0.5 g of Corydalis Corydalis reference medicinal material, 0.5 ml of ammonia solution (take 1 ml of concentrated ammonia test solution, add 10 ml of water, and mix well), grind, add 10 ml of dichloromethane, warm for 2 hours, filter, and concentrate the filtrate To about 1ml, as a reference medicinal solution.

[0105] Preparation of the reference substance solution: take the tetrahydropalmatine reference substance, add methanol to make a solution containing 0.1 mg per 1 ml, and use it as the reference substance s...

Embodiment 3

[0109] cassia seed identification

[0110] Preparation of the test solution: take 2 g of this product, add 1 ml of dilute hydrochloric acid and 20 ml of ether, heat and reflux for 30 minutes, evaporate the extract to the fullest extent of ether, add 1 ml of methanol to dissolve the residue, and obtain the product.

[0111] Preparation of blank solution: take the blank pharmaceutical preparation lacking cassia seed, and prepare blank solution according to the preparation method of the test solution.

[0112] Preparation of reference medicinal material: take 1 g of cassia seed reference medicinal material, add 0.5 ml of dilute hydrochloric acid and 20 ml of diethyl ether, reflux in water bath for 1 hour, take out, let cool, filter, recover diethyl ether from the filtrate to dryness, add 1 ml of methanol to dissolve the residue, and obtain.

[0113] Preparation of reference substance solution: take chrysophanol reference substance, emodin reference substance, emodin methyl ether ...

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Abstract

The invention relates to the medicinal field, and concretely relates to a blood nourishing and brain arousing particle quality detection method. The method comprises identification of ursolic acid in Spica Prunellae, identification of Rhizoma Corydalis, identification of Semen Cassiae, identification of Chinese angelica and Ligusticum wallichii, identification of rosmarinic acid in Spica Prunellae, identification of alkaloids in Ligusticum wallichii, identification of Levistilide in Ligusticum wallichii, identification of Millettia dielsiana, identification of white peony root, identification of prepared rehmannia root, identification of Gambir Plant, and determination of the content of an active ingredient paeoniflorin in the blood nourishing and brain arousing particle.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a quality detection method for Yangxue Xuenao Granules Background technique [0002] Yangxue Qingnao Granule is a modern traditional Chinese medicine preparation developed by Tianjin Tasly Pharmaceutical Co., Ltd. It obtained the National New Drug Certificate in 1996, was included in the National Essential Drug List in 1999, and was included in the National Medical Insurance Drug List in 2000. Yangxue Xuenao Granule is composed of 11 traditional Chinese medicines such as Angelica, Chuanxiong, Paeoniae Alba, Cassia Spatholobus, Cassia, and Corydalis Corydalis, which are extracted by modern high-tech means, added with appropriate excipients, and prepared by mixing and granulating. kind of granules. The preparation has the advantages of fast dissolution of active ingredients, high bioavailability and the like. Yangxue Qingnao Granule has the effects of nourishing blood, calming the liver, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/88
Inventor 孙玉侠高展刘彦莉曹凤兰
Owner 天士力东北现代中药资源有限公司
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