Liquid wound repairing film and preparation method thereof

A wound and liquid technology, applied in the field of liquid wound repair film and its preparation, can solve the problems of difficult to provide moist skin cell proliferation, wound healing, poor biocompatibility and biosafety, dust or water infiltration into the wound, etc. Restoration of appearance and function, good biocompatibility, prevention of skin cracking

Active Publication Date: 2014-11-19
ARNOKANG NINGXIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the products used for wound repair in the medical field, such as various wound plasters, have the advantages of low price and convenient use, and are often regarded as simple and easy wound treatment products. However, traditional wound plasters have the following disadvantages: (1) Poor air permeability , does not have the effect of waterproof and breathable; (2) It is poorly worn with the wound, and the wound is often fixed on the wound through the adhesive layer. The seal between the wound and the outside world is poor, and it is easy for dust or water to seep into the wound, making the wound infected and the scar too large; ( 3) All kinds of existing bandages have a fixed size, which is inconvenient to use on some specific wound sites
Of course, there are also researches on liquid bandages and products on the market at present, mainly mixing active ingredients that promote wound repair with film-forming chemicals, which has poor biocompatibility and biosafety. wound healing

Method used

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  • Liquid wound repairing film and preparation method thereof
  • Liquid wound repairing film and preparation method thereof
  • Liquid wound repairing film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] Preparation of carboxymethyl chitosan: Take 10.0g of chitosan in a three-necked flask, add 100mL of isopropanol, stir at 50-60°C for 10min, and divide 10mol / L NaOH 25mL solution into 5 batches for 20 minutes while stirring After the internal addition, stir for another 10 minutes, let it swell at room temperature for 12 to 15 hours, add 60 g of chloroacetic acid into the swollen chitosan in 5 batches, then raise the temperature to 60 ° C, continue to stir for 3 hours, stop, vacuum filter, and filter the residue After washing with ethanol several times, dry at 50°C to obtain carboxymethyl chitosan, and store it in a desiccator.

[0027] Infrared spectrum analysis: using KBr tablet, Avatar 370 Fourier transform infrared spectrometer to measure the prepared carboxymethyl chitosan, the results are shown in the IR spectrum at 1635.56cm -1 and 1385.22cm -1 The characteristic absorption peak of carboxymethyl sodium salt appeared at , indicating that carboxymethylation reaction...

Embodiment 1

[0041] Bottom solution preparation: take the CMC physiological saline solution with a concentration of 0.5 mg / mL prepared in the screening examples as the bottom solution.

[0042] Preparation of film solution: Weigh 1.5g of polyvinyl butyral, measure 30mL of 80% ethanol, heat and stir in a three-neck flask, and after the film-forming substance is completely dissolved, the film solution can be used as a liquid bandage.

[0043] When using, first apply the base liquid to the wound, and then apply the film liquid. The film liquid coated on the surface dries within 90s, which can effectively maintain the moist and sterile environment of the bottom liquid, and provide good conditions for wound healing.

Embodiment 2

[0045] Bottom solution preparation: the CMC physiological saline solution with a concentration of 1.0 mg / mL prepared in the screening example was used as the bottom solution.

[0046] Membrane solution preparation: weigh 3.5g of polyvinyl butyral, 0.3g of chitosan, measure 35mL of 95% ethanol, stir while heating in a three-necked flask, and add glycerol after the film-forming substance is completely dissolved 1mL was mixed and stirred evenly to obtain a film liquid, and the stirring speed was 300-400rpm. The resulting membrane solution is used as a liquid bandage.

[0047] Apply the film solution on the glass, tear it off after film formation, weigh 0.1g, put it into 100mL phosphate buffer solution simulated gastric simulated intestinal fluid (pH 7.45), stir at 37°C at a speed of 100rpm, and release for 180min. Draw 2mL solution therefrom at regular intervals, measure the content of chitosan, supplement the same volume of phosphate buffered saline solution at the same time. ...

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Abstract

The invention discloses a liquid wound repairing film and a preparation method thereof. The liquid wound repairing film comprises a base solution and a film solution, wherein the base solution is a physiological saline solution of carboxymethyl chitosan (CMC); the concentration of the carboxymethyl chitosan in the base solution is 0.5-5.0 mg / mL; the film solution comprises polyvinyl butyral (PVB) and an ethanol solution; the concentration of the ethanol solution is 80-100%; and the using amount of the polyvinyl butyral is 0.5-1.7 g in every 10mL of the ethanol solution. The liquid wound repairing film has the characteristics of quickness in drying, water tightness, breathability, bacterial resistance and the like, and is high in bio-safety and accurate in therapeutic effect.

Description

technical field [0001] The invention relates to a liquid wound repair film and a preparation method thereof. Background technique [0002] At present, the products used for wound repair in the medical field, such as various wound plasters, have the advantages of low price and convenient use, and are often regarded as simple and easy wound treatment products. However, traditional wound plasters have the following disadvantages: (1) Poor air permeability , does not have the effect of waterproof and breathable; (2) It is poorly worn with the wound, and the wound is often fixed on the wound through the adhesive layer. The seal between the wound and the outside world is poor, and it is easy for dust or water to seep into the wound, making the wound infected and the scar too large; ( 3) Various existing bandages have a fixed size, which is inconvenient to use on some specific wound sites. Therefore, if the traditional bandage is not used properly, it will often cause slow wound h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/42
Inventor 顾海鹰夏栋林李晓东何红王雨飞陈超陈燕培
Owner ARNOKANG NINGXIA BIOTECH
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