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Production method for extracting hyperin from pyrola rotundifolia

A technology of hyperin and its production method, which is applied in the direction of chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of high process cost and inferiority, and achieve complete extraction, high extraction efficiency, and reduced content Effect

Inactive Publication Date: 2013-04-10
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hyperin extraction process in the above-mentioned patent documents is mainly refined through extraction, macroporous resin adsorption, ion exchange resin adsorption and other steps. Although the final hyperin purity is very high, the process itself is costly and practical. The application effect is far inferior to that of countercurrent extraction combined with solvent extraction and macroporous resin adsorption separation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 500kg of wintergreen, pass through a 40-mesh sieve after being crushed into a coarse powder, add it at a constant speed at a rate of 50kg / h from the feeding port of the elevator, and add 75% acetone aqueous solution with a pipeline pump at a flow rate of 200kg / h through the liquid inlet pipe. The frequency of the elevator is set to 20Hz, the frequency of the host 1 is set to 16Hz, the frequency of the juicer 1 is set to 50Hz, the frequency of the host 2 is set to 22Hz, the frequency of the juicer 2 is set to 45Hz, and the crude hyperin Extraction 2T; the hyperin crude extract flows to the temporary storage tank by itself and is continuously pumped to the concentration tank by the outlet pump to concentrate to obtain 200L of hyperoside crude concentrate; adjust the valve of the material pump to make the hyperin crudely concentrate Liquid enters extraction tower with 1L / min, adjusts the solvent pump valve, makes ethyl acetate enter extraction tower with 3L / min, obtai...

Embodiment 2

[0027] Weigh 1.4T of wintergreen, crush it into a coarse powder, pass it through an 80-mesh sieve, add it from the feeding port of the elevator at a constant speed of 200kg / h, and add 75% acetone aqueous solution through the liquid inlet pipe at a flow rate of 600kg / h with a pipeline pump , the hoist frequency is set to 25Hz, the host 1 frequency is set to 18Hz, the juicer 1 frequency is set to 45Hz, the host 2 frequency is set to 20Hz, the juicer 2 frequency is set to 40Hz, and hyperin is obtained The crude extract is 4.2T; the crude hyperin extract is self-flowed to the temporary storage tank and is continuously pumped to the concentration tank by the outlet pump to concentrate to obtain 400L of hyperin crude concentrate; adjust the valve of the material pump to make the hyperin The crude concentrate enters the extraction tower at 0.5L / min, adjusts the solvent pump valve, and makes ethyl acetate enter the extraction tower at 2L / min to obtain 1.2T of hyperin ethyl acetate extr...

Embodiment 3

[0029] Take wintergreen 800kg, crush it into a coarse powder and pass through a 60-mesh sieve, add it at a constant speed of 80kg / h from the feed port of the elevator, and add 80% acetone aqueous solution with a pipeline pump at a flow rate of 250kg / h from the liquid inlet pipe. The frequency of the elevator is set to 22Hz, the frequency of the host 1 is set to 18Hz, the frequency of the juicer 1 is set to 50Hz, the frequency of the host 2 is set to 22Hz, the frequency of the juicer 2 is set to 45Hz, and the crude hyperin The extraction liquid is 2.5T; the crude hyperin extract is self-flowed to the temporary storage tank and is continuously pumped to the concentration tank by the outlet pump to concentrate to obtain 250L of the hyperin crude concentrate; adjust the valve of the material pump to make the hyperin crude The concentrated solution enters the extraction tower at 0.8L / min, and adjusts the solvent pump valve so that ethyl acetate enters the extraction tower at 2.4L / mi...

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PUM

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Abstract

The invention discloses a production method for extracting hyperin from pyrola rotundifolia. The method comprises the steps that raw materials are subjected to coarse grinding and then put in from a feeding hopper; an extraction tank unit host rotates; the materials are slowly pushed from the front end of a unit backwards; an extracting solvent enters an extracting tank from a liquid inlet tube at the tail end of the unit, passes through the moving materials from the rear end of the tank, and flows to the front end; and solid and liquid substances are sufficiently contacted in a reverse motion, so that active ingredients in medicinal materials are extracted. Dregs are forcibly pushed to a slag hole by a discharge transport and then discharged, a special juice squeezer extrudes the dregs and extrudes residual liquor in the dregs out of a medicinal material tissue, the residual liquor content of the dregs is reduced, the extraction efficiency is higher, and the extraction is more complete. The production method adopts continuous extraction and multi-stage extraction, and is combined with silicagel column chromatography for purification, the separation effect is better, and the finished hyperin with a maximum yield of 0.6% and content of above 95% can be obtained.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a production method of hyperin, in particular to a production method of hyperin in wintergreen by using countercurrent extraction combined with solvent extraction to absorb, separate and purify hyperin. Background technique: [0002] Wintergreen Pyrola rotundifolia ssp.chinensis, also known as Lushoucao, Poxuedan, Luhancao, Liuxiancao, is a plant of the genus Wintergreen in the family Wintergreen. Wintergreen contains N-phenyl-2-naphthylam-ine, chimaphilin, homoarbutin, gallic acid, Protocatechuic acid, wintergreen, quercetin, gallotannin, renifolin, 6-O-galloyl homoarbutin (6 -O-galloylhomoarbutin), hyperin (hyperin), galloyl hyperin (galloylhyperin). It has the functions of invigorating deficiency, nourishing the kidney, expelling wind and dampness, promoting blood circulation and regulating menstruation, treating weak cough, hematemesis due to fatigue, rheumatic joint...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 姚德坤姚德利张亚红姚航黄运生吴海龙
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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