Preparation method of sugar-free Masu anti-cough compound preparation

A compound preparation and sugar-free technology, which can be used in pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of difficult control of the stability of Masu cough preparations, easy hygroscopicity of sucrose, and high content of sucrose. Achieve the effects of increased contact area, high extraction rate and improved utilization rate

Active Publication Date: 2013-04-17
恒拓集团广西圣康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sucrose is mostly used as a flavoring agent in cough-relieving traditional Chinese medicine preparations. Because sucrose is easy to absorb moisture and requires more auxiliary materials for preparation, the dosage is large, and the stability of the prepared Masu cough-rel

Method used

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  • Preparation method of sugar-free Masu anti-cough compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1: Preparation of granules

[0060] Heat and reflux extract the fifteen flavors of medicinal materials such as ephedra ephedra for three times. For the first time, use 10 times the weight of the crude powder of the original drug to extract by heating and reflux for 2 hours with a pH value of 2.0, and filter; 2 times the weight of water with a pH value of 7.0, heated and refluxed for 2 hours, and filtered; for the third time, the filter residue was extracted with 8 times the weight of the raw drug coarse powder, heated and refluxed for 2 hours with a pH value of 8.0, and then filtered. The filtrates were combined and concentrated to a clear paste with a relative density of 1.10 (70°C). Add ethanol to the clear paste to make the alcohol content reach 70%, let it stand for 24 hours, filter, recover ethanol, and concentrate to a thick paste with a relative density of 1.20 (70°C). The thick paste was spray dried. During the drying process, the centrifugal speed i...

Embodiment 2

[0061] Example 2: Preparation of granules II

[0062] Heat and reflux extract the fifteen flavors of medicinal materials such as ephedra ephedra for three times. For the first time, use 10 times the weight of the crude powder of the original drug to extract by heating and reflux for 2 hours with a pH value of 2.0, and filter; 2 times the weight of water with a pH value of 7.0, heated and refluxed for 2 hours, and filtered; for the third time, the filter residue was extracted with 8 times the weight of the raw drug coarse powder, heated and refluxed for 2 hours with a pH value of 8.0, and then filtered. The filtrates were combined and concentrated to a clear paste with a relative density of 1.10 (70°C). Add ethanol to the clear paste to make the alcohol content reach 70%, let it stand for 24 hours, filter, recover ethanol, and concentrate to a thick paste with a relative density of 1.20 (70°C). The thick paste was spray dried. During the drying process, the centrifugal spee...

Embodiment 3

[0063] Example 3: Preparation of granules three

[0064] Heat and reflux extract the fifteen flavors of medicinal materials such as ephedra ephedra for three times. For the first time, use 10 times the weight of the crude powder of the original drug to extract by heating and reflux a 60% ethanol solution with a pH value of 2.0 for 2 hours, and filter; Coarse powder 8 times by weight pH value 7.0 concentration 60% ethanol solution heating and reflux extraction for 2 hours, filter; the third time filter residue with 8 times weight of the original drug coarse powder pH value 8.0 concentration 60% ethanol solution heating reflux extraction for 2 hours , filtered; the filtrates were combined, ethanol was recovered, and concentrated to obtain a clear paste with a relative density of 1.15 (70°C); 50 g of sucralose was dissolved in 500 g of 50% ethanol, mixed with the clear paste, and spray-dried, and the drying process was controlled: The centrifugal speed is 15000 rpm, the spray p...

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Abstract

The invention discloses a preparation method of a sugar-free Masu anti-cough compound preparation. Ethanol solution or/and water solution with different PH values is/are taken as a solvent, traditional Chinese medicine effective components are extracted by adopting a semi-bionic extraction method, and the traditional Chinese medicine components are as follows in part by weight: 200 parts of ephedra, 334 parts of perilla leaf, 334 parts of herba schizonepetae, 334 parts of notopterygium root, 334 parts of radix sileris, 334 parts of bitter almond, 666 parts of Cynanchum stauntoni, 666 parts of platycodon root, 666 parts of peucedanum, 334 parts of fructus aurantii, 134 parts of baical skullcap root, 400 parts of rhizoma typhonii flagelliformis, 334 parts of pericarpium citri reticulatae, 800 parts of Poria cocos and 200 parts of liquorice. The traditional Chinese medicines are respectively dried, finely crushed, extracted in a semi-bionic manner, filtered, concentrated and spray-dried to obtain extract fine powder, and the extract fine powder is mixed with auxiliary materials by adopting a conventional method to prepare tablet, capsule, granule, oral liquid, pill and dripping pill products. The preparation method provided by the invention can improve both the product quality and the production efficiency and save energy. The sugar-free preparation meets the demands of different patients and has better economic benefits and social benefits.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a preparation method of a sugar-free Masu antitussive compound preparation. Background technique [0002] Upper respiratory tract infection is the most common disease, often caused by exogenous pathogenic factors such as fever, cough, yellow phlegm, wheezing, sore throat and so on. At present, chemical drugs such as antibiotics, antipyretic and analgesics, cough-relieving and phlegm-reducing drugs are mainly used clinically for treatment. The stability of the curative effect is relatively poor, the side effects are large, and long-term use is relatively harmful to the human body. This type of treatment belongs to superficial methods, which cannot achieve the balance of yin and yang in the human body and the effect of radically curing diseases. And upper respiratory tract infection mostly belongs to viral infection, and antibiotic is often difficul...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P11/14
Inventor 苏军峰
Owner 恒拓集团广西圣康制药有限公司
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