Preparation method for stable iodinated vegetable oil ethyl ester

A technology for vegetable oil and oil ethyl ester, which is applied in the field of preparation of iodinated vegetable oil ethyl ester, can solve the problems of unsuitability for industrial production, long time, and multiple industrial waste water, and achieves improved production efficiency, good stability, and less industrial waste water. Effect

Inactive Publication Date: 2013-04-17
WUHAN INSTITUTE OF TECHNOLOGY
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Problems solved by technology

However, trialkylchlorosilanes are used in this method, and trialkylchlorosilanes are easily hydrolyzed to generate high-boiling compounds, which are difficult to remove from the reaction mixture, so this method is not suitable for industrial production
[0004] Patent CN101245002 reports a method for preparing iodized vegetable oil ethyl ester. In this process, the iodine that is unsteady in combination is removed by ventilating air. The time for ventilating air is long, which seriously affects industrial production efficiency. In addition, after the reaction is completed, , the alkali in the mixture needs to be washed many times with water to remove it, and the product is lost during the washing process, and there is a lot of industrial wastewater

Method used

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  • Preparation method for stable iodinated vegetable oil ethyl ester

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Embodiment 1

[0019] Embodiment 1 (synthesis of stable iodinated poppy seed oil ethyl ester):

[0020] 1). Synthesis of stabilized iodinated poppy seed oil,

[0021] At 25°C, add 100g of iodine and 15g of red phosphorus into the reactor, slowly drop into 20mL (that is, 20g) of water, and generate hydrogen iodide gas in the process, and pass the generated hydrogen iodide gas into a tank containing 100g In the reactor of poppy seed oil, the reaction time is 36 hours to obtain crude iodized poppy seed oil, wash 6 times with ethanol equivalent to 1 / 2 volume of crude iodized poppy seed oil, remove free iodine, and then use Concentration is 0.2mol / L sodium metabisulfite solution washes until its color and luster no longer becomes lighter, obtains iodinated poppy seed oil 143g. At 30°C, add 200ml of 5% aqueous hydrogen peroxide solution to the iodized poppy seed oil prepared above to remove iodine that is unstable in combination, keep stirring at 30°C for 5 hours, and then use a concentration of...

Embodiment 2

[0025] Embodiment 2 (synthesis of iodized peanut oil ethyl ester):

[0026] 1). Synthesis of stable iodinated peanut oil,

[0027] At 0°C, first mix 15g of red phosphorus with 20mL (20g) of water to obtain a suspension containing red phosphorus powder and water, add 100g of iodine into the reactor, and then slowly drop into the suspension containing red phosphorus powder and water Liquid, produce hydrogen iodide gas in this process, the hydrogen iodide gas that will produce is passed in the reactor that 100g peanut oil is housed, and the reaction time is 16 hours, obtains crude iodized peanut oil, with the equivalent crude iodine The ethanol washing of 1 / 8 volume of the peanut oil was washed 10 times to remove free iodine, and then washed with a 0.2mol / L sodium metabisulfite solution until its color was no longer lightened to obtain 148g of iodized peanut oil. At 25°C, add 100ml of 13% aqueous hydrogen peroxide solution to the iodized peanut oil prepared above to remove iodi...

Embodiment 3

[0031] A preparation method of stable iodized vegetable oil ethyl ester, it comprises the steps:

[0032] 1) Synthesis of stable iodized vegetable oil:

[0033]The mass ratio of vegetable oil, iodine, red phosphorus and water is 100g: 100g: 15g: 20g to select vegetable oil, iodine, red phosphorus and water, and the vegetable oil is sunflower oil, linseed oil and corn oil, sunflower oil, linseed The quality of oil and corn oil each accounts for 1 / 3; at 20°C, add 100g of iodine and 15g of red phosphorus into the reactor, slowly drop into 20mL (ie 20g) of water, during this process hydrogen iodide gas is generated, and the The hydrogen iodide gas that produces passes in a reactor that 100g vegetable oil is housed, and the reaction time is 24 hours, obtains crude iodized vegetable oil, washes 7 times with the ethanol that is equivalent to crude iodized vegetable oil 1 / 2 volume, removes The free iodine is then washed with a 0.5mol / L sodium metabisulfite solution until its color is...

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Abstract

The invention relates to a preparation method for stable iodinated vegetable oil ethyl ester. The method mainly includes the following steps: performing addiction reaction between vegetable oil and hydrogen iodide gas to generate iodinated vegetable oil; removing unstable iodine incorporated in the iodinated vegetable oil by adding hydrogen peroxide; eliminating removed iodine by using sodium metabisulfite solution to obtain stable iodinated vegetable oil; and performing ester exchange reaction between the stable iodinated vegetable oil and ethanol under the function of basic catalyst to produce the stable iodinated vegetable oil ethyl ester. The iodinated vegetable oil ethyl prepared by using the method has the characteristics of small viscosity and environmental-friendly technology.

Description

technical field [0001] The invention relates to a preparation method of stable iodized vegetable oil ethyl ester. Background technique [0002] Contrast medium, also known as contrast medium, is one of the most commonly used diagnostic reagents in interventional radiology operations, mainly used for the display of blood vessels and body cavities. There are various types of contrast agents, and most of the contrast agents currently used in X-ray diagnostics are iodine-containing preparations, that is, the main component is iodine. The iodized oil currently produced in my country has not undergone transesterification and has relatively high viscosity, which is mainly used to prevent and treat endemic goiter. Iodine deficiency is still a serious threat to human health and development worldwide, and iodine deficiency leads to goiter, stillbirth and miscarriage. In recent years, medical workers from all over the world have made unremitting explorations in the fight against dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11C3/00C11C3/10
Inventor 柏正武郭镇陈伟奚江波季珉
Owner WUHAN INSTITUTE OF TECHNOLOGY
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