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Antineoplastic application of Hederagenin-3-O-arabinopyranoside

An anti-tumor and anti-tumor drug technology, applied in the field of medicine

Inactive Publication Date: 2013-04-24
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on S. japonica, only Liao Xun, Li Bogang et al. have carried out research on the chemical components of S. japonica, from which 8 osmanthrin A, osmanthin B, and osmanthus lactone were isolated. compound

Method used

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  • Antineoplastic application of Hederagenin-3-O-arabinopyranoside
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  • Antineoplastic application of Hederagenin-3-O-arabinopyranoside

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 Hederagenin-3-O-arabinopyranoside

[0039] Weigh 10kg of tiger palm herb crude powder, add 6 times the amount of methanol, cold soak at room temperature 5 times, each time not less than 24h, filter, combine the filtrate, recover the filtrate under reduced pressure, vacuum dry, crush, and obtain dry extract 1 . Weigh the above dry extract 1, add ethyl acetate equivalent to 5 times the amount of extract, reflux extraction four times, two hours for the first time, one hour for the second, third, and fourth times, filter, combine the filtrate, and extract Concentrate under reduced pressure and dry in vacuo to obtain ethyl acetate extracts. Take the extracted part of ethyl acetate, mix the sample with silica gel (80-100 mesh), and then perform silica gel column chromatography (200-300 mesh), and use chloroform, chloroform-methanol (9:1), chloroform-methanol (8:2), Chloroform-methanol (7:3) and chloroform-methanol (6:4) were used for gradient...

Embodiment 2

[0041] Take 5.0g of Hederagenin-3-O-arabinopyranoside, 10.0g of starch, and 7.85g of microcrystalline cellulose, pass through an 80-mesh sieve, mix well, add 3% hydroxypropyl cellulose and stir to make a soft material, pass through a 16-mesh sieve Dry the wet granules below 50°C, pass the dry granules through a 16-mesh sieve, add 1.0 g of croscarmellose sodium and 0.75 g of magnesium stearate, mix well, and press into 100 tablets. Each tablet weighs 0.25g, contains Hederagenin-3-O-arabinopyranoside 50mg, and can be used for the treatment of gastric cancer.

Embodiment 3

[0043] Grind Hederagenin-3-O-arabinopyranoside into powder, pass through an 80-mesh sieve, mix 5.0 g with 11.5 g of starch and 8.5 g of micronized silicon, sieve, pack into capsules, and make 100 capsules. Each capsule weighs 0.25g, contains Hederagenin-3-O-arabinopyranoside 50mg, and can be used for the treatment of liver cancer.

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Abstract

The invention relates to application of hederagenin-3-O-arabinopyranoside (hederagenin-3-O-arabinopyranoside). The Hederagenin-3-O-arabinopyranoside is obtained by utilizing a chemical extraction separation method. The chemical compound structure of the hederagenin-3-O-arabinopyranoside is identified by utilizing physical constants and spectroscopy methods to carry out an antineoplastic pharmacological testing for the hederagenin-3-O-arabinopyranoside, a result shows that the hederagenin-3-O-arabinopyranoside has good effect on antineoplastic aspects ,especially has good effects on restraining human breast cancer cells, sarcoma cells, gastric carcinoma cells, hepatoma carcinoma cells and prostate cancer cells. The hederagenin-3-O-arabinopyranoside can be used for preparing medicines for curing breast cancer, solid tumor, gastric cancer, liver cancer and prostate cancer.

Description

technical field [0001] The invention relates to the application of Hederagenin-3-O-arabinopyranoside (hederagenin-3-O-arabinoside) in the prevention and treatment of tumors, belonging to the field of medicine. Background technique [0002] Cancer is currently one of the major diseases that endanger human health and normal life. Especially in recent years, with the deterioration of the environment, the incidence of malignant tumors has shown an obvious upward trend. The research and development of anticancer drugs has always been a hot spot chosen by scientists. Research and development of new, efficient and low-toxic antitumor drugs has become a top priority. At present, 67,000 anticancer active ingredients have been screened from higher plants in the world, which has opened up a vast world for the treatment of malignant tumors. my country has also carried out anti-tumor screening on more than 3,000 Chinese herbal medicines from 28 families and genera, of which about 200 ar...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P35/00
Inventor 冯莉萍崔涛朱兆云王京昆吴德松孙敏
Owner YUNNAN INST OF MATERIA MEDICA
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