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A drug for regulating liver regeneration and its prevention and treatment scheme

A technology of liver regeneration and traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., can solve the problem that the curative effect needs to be further improved, and achieve the effect of improving clinical curative effect and improving liver tissue

Inactive Publication Date: 2016-11-09
李瀚旻
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the treatment of chronic hepatitis B with traditional Chinese medicine has gone through hotspots such as anti-virus, anti-liver injury, anti-hepatic fibrosis, and immune regulation, and has played an indelible role in achieving the overall goal of treating chronic hepatitis B, which is currently recognized at home and abroad. It has a certain curative effect, but its curative effect needs to be further improved

Method used

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  • A drug for regulating liver regeneration and its prevention and treatment scheme
  • A drug for regulating liver regeneration and its prevention and treatment scheme
  • A drug for regulating liver regeneration and its prevention and treatment scheme

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach (1

[0014] Implementation plan (1): Use Diwu Yanggan Fang traditional Chinese medicine free decoction granules (rehmannia glutinosa 15 grams, capillary wormwood 12 grams, turmeric 6 grams, schisandra chinensis 9 grams, licorice 5 grams) syndrome differentiation and taste, and take it with boiled water twice a day . The decoction-free traditional Chinese medicine granules can be commercially available products such as Jiangyin Tianjiang Pharmaceutical Co., Ltd., Shenzhen Sanjiu Modern Chinese Medicine Co., Ltd., and Guangdong Yifang Pharmaceutical Co., Ltd., and can also be made into single-drug granules according to modern technology (Hubei Province Chinese medicine granules) preparations in hospitals). Adding flavors based on clinical syndrome differentiation: ① For severe heat-toxins such as yellow urine and yellow greasy tongue coating, add 15 grams of Phyllostachys phylloxera and 15 grams of Hedyotis diffusa; 15 grams; ③Those with hypochondriac pain, localized pain, dark purp...

Embodiment approach (2

[0015] Embodiment (2): Adopt scheme (1) in combination with western antiviral drugs (interferon, internal nucleoside analogs: lamivudine, adefovir, telmivudine, entecavir, etc.) to treat viral hepatitis.

Embodiment approach (3

[0016] Implementation Plan (3): Clinical Research Plan for the Treatment of Chronic Hepatitis B by Tonifying the Kidney and Eliminating Pathogens

[0017] 1 Research Objectives

[0018] 1.1 Short-term goals

[0019] In view of the syndrome characteristics of HBeAg-negative chronic hepatitis B, based on the research results of "tonifying the kidney, generating marrow and forming the liver", the "Diwu Yanggan Prescription" with the effect of "tonifying the kidney and eliminating pathogenic factors" combined with entecavir to treat HBeAg Negative chronic hepatitis B has obtained high-level clinical evidence through multi-center, randomized, controlled, blinded clinical research, and the research results have been recognized by the industry at home and abroad. Develop an integrated traditional Chinese and western medicine treatment plan for clinical promotion and application, and improve the clinical efficacy of chronic hepatitis B.

[0020] Objective: To preliminarily form an i...

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Abstract

The invention discloses a compound composition of traditional Chinese medicine granules for regulating liver regeneration and prevention and treatment methods for chronic liver diseases by using the compound alone or in combination with antiviral medicine. The medicine is composed of: 5-30 parts of prepared Chinese foxglove root, 5-30 parts of virgate wormwood, 3-9 parts of turmeric, 3-12 parts of licorice, 3-15 parts of schisandra fruit, 5-15 parts of underleaf pearl, 5-30 parts of diffusa , 5-30 parts of poria, 5-30 parts of coix seed, 5-30 parts of salvia fruit, 1-10 parts of curcuma rhizome, 3-12 parts of dodder, and 5-15 parts of mistletoe For people suffering from chronic liver diseases (drug-induced liver disease, alcoholic or non-alcoholic fatty liver disease, autoimmune liver disease, viral hepatitis, etc.) which have high risk of liver failure, liver cirrhosis, and liver cancer, and people suffering from liver cancer or people after liver cancer surgery, clinical and experimental evidences show that the traditional Chinese medicine granules have synergies of regulation of liver regeneration and anti-virus, anti-liver injury, anti-liver fibrosis, and liver cancer prevention, and a relatively high level of clinical evidence based medicine evidences are obtained.

Description

technical field [0001] The invention relates to a medicine for regulating and controlling liver regeneration (compound of traditional Chinese medicine granules) and its prevention and treatment scheme. Background technique [0002] In the existing research on the treatment of chronic liver diseases (viral hepatitis accounts for the majority), there are many viral factors, such as the relationship between viral load, viral genotype, viral mutation and drug resistance, and prognosis. However, there are few studies on host factors (genetics, age, gender, immune status, liver regeneration status, behavioral habits, psychological factors, working conditions, diet, drug-induced liver injury, environmental factors, etc.). The direct effect of traditional Chinese medicine on hepatitis viruses (HBV, HCV, etc.) is not as good as the current antiviral drugs of Western medicine, but Chinese medicine prevents or delays the progress of the disease and promotes recovery by intervening in c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/16A61P1/16A61P35/00A61P31/12A61P31/14A61P31/20
Inventor 李瀚旻
Owner 李瀚旻
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