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Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof

A chemotherapeutic drug and composition technology, applied in the directions of drug combinations, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve the problems of patient injury and pain, lack of experimental basis, unclear treatment mechanism and other problems, so as to reduce local inflammatory reactions, The effect of promoting proliferation and repair, simple preparation method

Inactive Publication Date: 2014-09-17
冯莉霞 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs used clinically, such as magnesium sulfate, lidocaine, dexamethasone, vitamin B12, Hirudoid, ethanol, nitroglycerin, etc., but the mechanism of the treatment method adopted is still unclear and lacks sufficient experimental basis. The research lacks scientific design and control, which leads to lack of pertinence in clinical treatment and nursing measures, and even some treatment methods can cause new injuries and pains to patients

Method used

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  • Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof
  • Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof
  • Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0037] A traditional Chinese medicine composition for preventing and treating chemotherapy drug extravasation injury, which is composed of Corydalis Corydalis, Puhuang, Arborvitae Carbon, Rhubarb, Borneol, Aescin and Ferulica, wherein Corydalis Corydalis 30kg, Puhuang 25kg, Arborvitae Carbon 40kg, rhubarb 35kg, borneol 9kg, aescin 12kg, asafoetida 20kg.

[0038] The preparation method of the above-mentioned traditional Chinese medicine composition for preventing and treating chemotherapy drug extravasation damage, the specific preparation steps are as follows:

[0039] (1) Weighing Corydalis Corydalis, Puhuang, Arborvitae Carbon, Rhubarb, Borneol, Aescin and Asafoetida as raw materials, crushing each Chinese medicinal material and passing it through a 120-mesh sieve to obtain the powder of each Chinese medicinal material;

[0040] (2) Weigh the crushed Chinese medicinal material powder in step (1), including 30kg Corydalis Corydalis, 25kg Puhuang, 40kg Arborvitae Carbon, 35kg ...

Embodiment 2

[0043]A traditional Chinese medicine composition for preventing and treating chemotherapy drug extravasation injury, which is composed of Corydalis Corydalis, Puhuang, Arborvitae Carbon, Rhubarb, Borneol, Aescin and Ferulica, wherein Corydalis Corydalis 10kg, Puhuang 50kg, Arborvitae Carbon 60kg, rhubarb 10kg, borneol 5kg, aescin 20kg, asafoetida 5kg.

[0044] The preparation method of the above-mentioned traditional Chinese medicine composition for preventing and treating chemotherapy drug extravasation damage, the specific preparation steps are as follows:

[0045] (1) Weighing Corydalis Corydalis, Puhuang, Arborvitae Carbon, Rhubarb, Borneol, Aescin and Ferulicum as raw materials, crushing each Chinese medicinal material and passing it through a 200-mesh sieve to obtain the powder of each Chinese medicinal material;

[0046] (2) Weigh the crushed Chinese herbal medicine powder in step (1), including Corydalis Corydalis 10kg, Puhuang 50kg, Arborvitae Carbon 60kg, Rhubarb 10k...

Embodiment 3

[0049] A traditional Chinese medicine composition for preventing and treating chemotherapy drug extravasation injury, which is composed of Corydalis Corydalis, Puhuang, Arborvitae Carbon, Rhubarb, Borneol, Aescin and Ferulica, wherein Corydalis Corydalis 50kg, Puhuang 10kg, Arborvitae Carbon 10kg, 50kg rhubarb, 15kg borneol, 5kg Aescin, 30kg asafoetida.

[0050] The preparation method of the above-mentioned traditional Chinese medicine composition for preventing and treating chemotherapy drug extravasation damage, the specific preparation steps are as follows:

[0051] (1) Weighing Corydalis Corydalis, Puhuang, Arborvitae Carbon, Rhubarb, Borneol, Aescin and Ferulicum as raw materials, crushing each Chinese medicinal material and passing it through a 60-mesh sieve to obtain the powder of each Chinese medicinal material;

[0052] (2) Weigh the crushed Chinese herbal medicine powder in step (1), including 50kg Corydalis Corydalis, 10kg Puhuang, 10kg Arborvitae Carbon, 50kg Rhuba...

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight of 10-50 parts of corydalis tuber, 10-50 parts of pollen typhae, 10-60 parts of oriental arborvitae carbon, 10-50 parts of rheum officinale, 5-15 parts of borneol, 5-20 parts of paris polyphylla, and 5-30 parts of ferula asafetida. The traditional Chinese medicine composition is prepared in crushing and mixing manners; the expression of ICAM-1 (intercellular adhesion molecule) in affected vein and surrounding tissue is reduced by the traditional Chinese medicine composition; local inflammatory response is reduced; meanwhile, the expression of endothelial cell VEGF (vascular endothelial growth factor) in the affected vein is regulated upwards; proliferation and repair of vascular endothelial cell are facilitated; healing of inflammation is facilitated; and necrotizing phlebitis caused by strongly stimulated chemotherapy drugs exosmosis can be treated instead of a surgical method, so as to achieve the healing effect. The traditional Chinese medicine composition is simple in preparation method and suitable for the requirements of large-scale industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for preventing and treating chemotherapeutic drug extravasation damage and its preparation method and application. Background technique [0002] Malignant tumors rank third among the leading causes of death in the world. Chemotherapy with antineoplastic drugs (referred to as chemotherapy) has become one of the three main means of comprehensive treatment of malignant tumors after surgery and radiotherapy. Clinical applications are becoming more and more popular. It has become an indispensable part of comprehensive tumor treatment, and gradually transitioned from palliative treatment to radical treatment. Intravenous administration is the most commonly used method of administration. Chemotherapy phlebitis often occurs during the administration process. The so-called chemotherapy phlebi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K36/88A61P9/14A61K31/045
Inventor 冯莉霞王华庆贺瑾
Owner 冯莉霞
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