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Preparation method and application of spiral-shaped nucleus pulposus prosthesis for minimally invasive surgery

A minimally invasive surgery, spiral-shaped technology, applied in the direction of prosthesis, medical science, tissue regeneration, etc., can solve the difficulty in meeting the clinical requirements of minimally invasive implantation of the nucleus pulposus, difficult polymerization speed and exothermic reaction, silicone rubber anti-fatigue and Limited wear resistance and other problems, to achieve the effects of good non-slip stability, excellent comprehensive mechanical properties and stability, and good shape memory

Inactive Publication Date: 2013-05-15
HAERBIN ZHAOYANG BINHUI IND DEV GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyurethane has better pressure resistance and cushioning ability than silicone rubber, but the anti-fatigue and wear resistance of silicone rubber are limited. It is difficult for polyurethane to control the polymerization rate and exothermic reaction of monomers. Moreover, due to the toxic effects of the monomers, the proportion of its components needs to be strictly controlled, and it is difficult to meet the clinical requirements of minimally invasive implantation of the nucleus pulposus.

Method used

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  • Preparation method and application of spiral-shaped nucleus pulposus prosthesis for minimally invasive surgery
  • Preparation method and application of spiral-shaped nucleus pulposus prosthesis for minimally invasive surgery
  • Preparation method and application of spiral-shaped nucleus pulposus prosthesis for minimally invasive surgery

Examples

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Effect test

Embodiment 1

[0040] This example describes a method for preparing a bionic artificial nucleus pulposus prosthesis for minimally invasive percutaneous-puncture surgery.

[0041] a) Mix polyvinyl alcohol particles with an average degree of polymerization of 1750±50 and deionized water at a mass ratio of 20:80, and stir evenly with a glass rod.

[0042] b) Put the weighed mixed solution into an autoclave for 2 hours under high temperature and high pressure to melt at 120 MPa, and stir in the autoclave during the melting process to ensure the uniformity of the solution.

[0043] c) The glue liquid flows into the spiral mold from the discharge port to form, so that the glue liquid can fully fill the cavity of the mold, and stand still for 20 minutes to remove the air bubbles generated during the pouring process.

[0044] d) Naturally cool the mold filled with glue to room temperature, put it in the refrigerator, freeze at -20°C for 8 hours, cool slowly at 0°C for 3-4 hours after freezing, and t...

Embodiment 2

[0048] The process method of this example is the same as that of Example 1, except that the mass ratio of polyvinyl alcohol particles with an average degree of polymerization of 1750±50 to deionized water is 15:85.

Embodiment 3

[0050] The process method of this embodiment is the same as that of Example 1, the only difference is that the mass ratio of polyvinyl alcohol particles with an average degree of polymerization of 1750±50 to deionized water is 25:75

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Abstract

The invention relates to a preparation method and an application of a spiral-shaped nucleus pulposus prosthesis for a minimally invasive surgery. The preparation method and the application of the spiral-shaped nucleus pulposus prosthesis for the minimally invasive surgery are suitable for implantation of an minimally invasive percutaneous-puncture operation, are used for treating cervical vertebra and lumbar intervertebral disc pathological changes, and belong to the field of biomedical materials. The preparation method of the spiral-shaped nucleus pulposus prosthesis for minimally invasive surgery is characterized in that polyvinyl alcohol (PVA) and deionized water with a certain mass ratio are mixed to form colloidal sol under the conditions of high temperature and high pressure, the bionic spiral-shaped nucleus pulposus prosthesis with good biomechanical properties is obtained after freezing-unfreezing circulation and gamma ray radiation and other methods are carried out on the colloidal sol in a specific mold for several times. The nucleus pulposus prosthesis is implanted through a minimally invasive-puncture surgical instrument. After the nucleus pulposus prosthesis passes through the surgical instrument, the spiral shape is recovered, shape memory property is good, the nucleus pulposus prosthesis can be taken out through the minimally invasive percutaneous-puncture operation, and therefore safety is high. The nucleus pulposus prosthesis is good in biocompatibility, biomechanical property is close to the human body nucleus pulposus, and the requirement of nucleus pulposus medical service is met. Swelling properties can meet the requirements of postoperative recovery and enlisting.

Description

technical field [0001] The invention relates to the technical field of novel medical bionic materials, in particular to a preparation method and application of a bionic coiled nucleus pulposus prosthesis for minimally invasive percutaneous-puncture surgery. Background technique [0002] Intervertebral disc disease is a common and frequently-occurring disease, among which cervical and lumbar disc disease is the most common, which seriously affects the working ability and quality of life of patients, and is highly valued by the society. In intervertebral disc lesions, total disk replacement is generally required after the nucleus pulposus and annulus fibrosus are completely destroyed. This operation is traumatic and the long-term effect is not obvious. For general degeneration of the nucleus pulposus, the annulus fibrosus is intact, and only the nucleus pulposus replacement is required at this time. Artificial nucleus pulposus replacement maintains the normal physiological mo...

Claims

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Application Information

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IPC IPC(8): A61F2/44
CPCA61L27/52C08L29/04A61F2/40C08J3/075A61F2/442A61F2002/30075A61F2002/30291A61F2002/444A61L27/16A61L2430/38C08J2329/04
Inventor 高瑾李晓刚高立军朱微
Owner HAERBIN ZHAOYANG BINHUI IND DEV GRP
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