Soluble hemostatic gauze and preparation methods thereof

A hemostatic gauze, soluble technology, applied in the field of soluble hemostatic gauze and its preparation, can solve the problems of inconvenient use process, gauze curling, low fiber crystallinity and the like

Active Publication Date: 2013-05-29
FOSHAN UNITED MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fiber crystallinity of the above-mentioned patent is not high, and the strength is not high, and the obtained soluble hemostatic gauze absorbs water too sticky, and is easy to curl
[0005] In addition, in the traditional process, after carboxymethylation of cellulose fiber (also known as viscose fiber), the water absorption capacity is greatly improved due to the increase in the content of carboxymethyl groups, but it can be made into soluble hemostatic gauze and anti-adhesion After the gauze, it is inconvenient to use after absorbing water or the viscosity is too large; or the gel is opaque and the gauze is curled, which will have a bad effect on wound healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) At room temperature, 1 g of solvent-spun cellulose fibers (Lyocel filaments, purchased from Hyosung, Korea) were mechanically dispersed with hot water at 50°C for 5 minutes.

[0044] (2) React 1 g of the solvent-spun cellulose fiber obtained in (1) with 100 ml of 18% aqueous sodium hydroxide solution for 30 minutes at room temperature;

[0045] (3) React the fiber obtained in (2) with 20ml of 30.6% ethanol solution of sodium chloroacetate at 70°C for 50min;

[0046] (4) The fibers obtained in (3) were washed twice with 120 g of acid washing solution (containing 2.5% by weight of acetic acid, 42.5% by weight of water and 55% by weight of ethanol), and then 100 g of 1% by weight of Washing with absolute ethanol solution of Tween 20;

[0047] (5) Dry the fibers obtained in (4) at 30°C for 15 minutes to obtain white carboxymethylated cellulose fibers with a degree of substitution of 0.55 and an absorption capacity of 34.2 g / g (solution A, solution A It is a solution f...

Embodiment 2

[0050] (1) Disperse 1 g of solvent-spun cellulose fiber (Lyocel filament, purchased from Hyosung, Korea) with hot water at 50°C by mechanical force for 5 minutes at room temperature;

[0051] (2) React 1 g of the solvent-spun cellulose fiber obtained in (1) with 100 ml of 18% aqueous sodium hydroxide solution for 30 minutes at room temperature;

[0052] (3) React the fibers obtained in (2) with 20ml of 30.6% sodium chloroacetate ethanol solution at 100°C for 33 minutes;

[0053] (4) The fibers obtained in (3) were washed twice with 120 g of acid washing solution (containing 2.5% by weight of acetic acid, 42.5% by weight of water and 55% by weight of ethanol), and then 100 g of 1% by weight of Washing with absolute ethanol solution of Tween 20;

[0054] (5) Air-dry the fibers obtained in (4) at 30°C for 15 minutes to obtain white carboxymethylated cellulose fibers with a degree of substitution of 0.69 and an absorption capacity of 40.3 g / g (solution A). into a transparent gel...

Embodiment 3

[0057] (1) Disperse 1 g of solvent-spun cellulose fiber (Lyocel filament, purchased from Hyosung, Korea) with hot water at 50°C by mechanical force for 5 minutes at room temperature;

[0058] (2) React 1 g of the solvent-spun cellulose fiber obtained in (1) with 100 ml of 18% aqueous sodium hydroxide solution for 30 minutes at room temperature;

[0059] (3) React the fibers obtained in (2) with 15ml of 30.6% sodium chloroacetate aqueous solution at 100°C for 33 minutes;

[0060] (4) The fibers obtained in (3) were washed twice with 120 g of acid washing solution (containing 2.5% by weight of acetic acid, 42.5% by weight of water and 55% by weight of ethanol), and then 100 g of 1% by weight of Washing with absolute ethanol solution of Tween 20;

[0061] (5) Air-dry the fibers obtained in (4) at 30°C for 15 minutes to obtain white carboxymethylated cellulose fibers with a degree of substitution of 0.72 and an absorption capacity of 42.3 g / g (solution A). into a transparent gel...

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Abstract

The invention relates to soluble hemostatic gauze prepared from carboxymethylated solvent woven cellulosic fiber and preparation methods thereof. According to one method for preparing the soluble hemostatic gauze, the carboxymethylated solvent woven cellulosic fiber is respectively alkalized and etherified respectively by sodium hydroxide solution and sodium chloroacetate solution step by step. In addition, the invention further provides another method for preparing the soluble hemostatic gauze, wherein the carboxymethylated solvent woven cellulosic fiber is further alkalized and etherified in one step by a mixed solution of sodium hydroxide and sodium chloroacetate. According to the invention, the carboxymethylated cellulosic fiber with high transparency, high degree of substitution and high water-absorbing quality can be prepared at a low temperature, and the soluble hemostatic gauze provided by the invention can be prepared.

Description

technical field [0001] The invention relates to a soluble hemostatic gauze and a preparation method thereof, in particular to a soluble hemostatic gauze prepared from carboxymethylated solvent-spun cellulose fibers and a preparation method thereof. Background technique [0002] At present, there are many kinds of wound absorbable hemostatic materials on the market, mainly including fibrin glue, collagen, chitosan, carboxymethyl cellulose (soluble hemostatic gauze) and so on. An ideal biological hemostatic material should have the following characteristics: rapid hemostasis, no toxicity, no antigenicity, no increase in the probability of infection, no influence on tissue healing, and low price. [0003] Soluble hemostatic gauze has a strong affinity for water and saline, it can quickly absorb the water in the blood and dissolve it when it encounters blood, and the formed colloid blocks the ends of capillaries, promotes blood concentration, increases viscosity, and slows down ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/62D06M11/38D06M13/21D06M101/06
CPCA61L15/28A61L15/42D06M13/21A61L2400/04A61L15/62D06M11/38C08L1/286
Inventor 吕秋兰王晓东
Owner FOSHAN UNITED MEDICAL TECH
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