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Carthamin yellow sublingual tablet and preparation method and application thereof

A technology of safflower yellow pigment and sublingual tablet, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Large and other problems, to achieve the best disintegration effect, good taste and appearance, and the effect of rapid absorption

Active Publication Date: 2013-06-05
ZHEJIANG YONGNING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the relatively short half-life of safflower yellow and poor gastrointestinal absorption when taken orally, it is generally believed that the potential for preparation of oral preparations is not great

Method used

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  • Carthamin yellow sublingual tablet and preparation method and application thereof
  • Carthamin yellow sublingual tablet and preparation method and application thereof
  • Carthamin yellow sublingual tablet and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 different fillers

[0026] Using different types of fillers as shown in Table 1, according to the formula of 100mg per tablet containing safflower yellow pigment, 400mg filler, 100mg croscarmellose sodium and 5mg magnesium stearate, it is prepared by powder direct compression method slices, and the results are shown in Table 1.

[0027] Table 1

[0028] serial number

[0029] As can be seen from the results in Table 1, mannitol, sorbitol, xylitol and lactose can all be formed into tablets and have better mouthfeel, especially mannitol, sorbitol and xylitol can realize better mouthfeel. In addition, considering the high price of sorbitol and xylitol, it is most preferable to use mannitol.

Embodiment 2

[0030] The safflower yellow pigment sublingual tablet of embodiment 2 different disintegrants and preparation method

[0031] 1. Preparation of powder by direct compression method

[0032] Using different types of disintegrants as shown in Table 2, according to the formula containing 100mg safflower yellow pigment, 300mg lactose, 200mg disintegrant and 5mg magnesium stearate per tablet, prepared by powder direct compression method, the results are shown in the table 2.

[0033] Table 2

[0034] serial number

[0035] 2. Wet granulation preparation

[0036] Adopt different kinds of disintegrants as shown in table 3, contain 100mg safflower yellow pigment, 400mg mannitol, 100mg disintegrator and the prescription of 5mg magnesium stearate by every tablet, with following wet granulation tabletting method (additional method), and the results are shown in Table 3.

[0037] Wet granulation (external addition method): weigh safflower yellow and mannitol according to the...

Embodiment 3

[0041] Example 3 Safflower Yellow Sublingual Tablets with Different Proportions

[0042] Formula (mg / tablet): Except for fillers and disintegrants as shown in Table 4, others are: 100 mg of safflower yellow, 5 mg of magnesium stearate.

[0043] Preparation method: powder direct compression method

[0044] Table 4

[0045] serial number

Mannitol

Croscarmellose Sodium

Disintegration time (n=6)

Disintegration time limit

1

500mg

0mg

9-10min

unqualified

2

450mg

50mg

6-7min

unqualified

3

400mg

100mg

4-5min

qualified

4

300mg

200mg

4min

qualified

[0046] It can be seen from the results in Table 4 that when the dosage ratio of mannitol and croscarmellose sodium is 4:1, the qualified disintegration time limit has been reached, and it is not meaningful to increase the dosage of disintegrating agent, and it will make the taste worse, so Most preferred i...

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Abstract

The invention discloses a carthamin yellow sublingual tablet. The carthamin yellow sublingual tablet comprises, by weight, one part of carthamin yellow, 3-4 parts of filling agents and 1-2 parts of disintegrating agents. The filling agents are one or more of mannitol, sorbitol, xylose and lactose. The disintegrating agents are one or more of crosslinking povidone, cross-linked carboxymethyl starch and sodium carboxymethyl cellulose and sodium. The invention further discloses the preparation method of the carthamin yellow sublingual tablet and application in preparing medicines for curing ischemic brain injury. The carthamin yellow sublingual tablet has good disintegrating effect, can be absorbed quickly, has good taste and appearance, and provides a new way for clinical application of carthamin yellow.

Description

technical field [0001] The invention relates to a safflower yellow pigment sublingual tablet, a preparation method and application thereof. Background technique [0002] Safflower yellow is a natural pigment extracted from Compositae safflower. It has the effects of promoting blood circulation and removing blood stasis, dredging channels and relieving pain. It can be used to treat I, II and III grades of stable exertional angina pectoris caused by blood stasis. (Symptoms include chest pain, chest tightness, palpitation and shortness of breath, etc.). [0003] At present, the safflower yellow preparation is only powder for injection, and the development of new dosage forms is extremely important for expanding its clinical application. Due to the relatively short half-life of safflower yellow and its poor gastrointestinal absorption when taken orally, it is generally believed that the potential for preparing oral preparations is not great. Contents of the invention [0004...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K36/286A61K31/351A61K47/38A61K47/36A61K47/32A61K47/26A61P9/10
Inventor 叶凤起卢敏陈勇灵余荷秀蒋正平
Owner ZHEJIANG YONGNING PHARMA
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