Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Grafted copolymer and preparation method thereof and layer-by-layer decorative materials

A graft copolymer and modified material technology, applied in the field of graft copolymer, its preparation method and layer-by-layer modified materials, can solve the problems of no electrical activity, etc., achieve good water solubility, good composite layers, good electrical Effect of Chemical Response Properties

Active Publication Date: 2013-06-05
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
View PDF3 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the tissue engineering materials disclosed in the prior art has electrical activity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Grafted copolymer and preparation method thereof and layer-by-layer decorative materials
  • Grafted copolymer and preparation method thereof and layer-by-layer decorative materials
  • Grafted copolymer and preparation method thereof and layer-by-layer decorative materials

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] The present invention also provides a kind of preparation method of graft copolymer, comprising:

[0058]A) Mix the initiator with the acid anhydride in the amino acid ring, carry out ring-opening polymerization, and then deprotect to obtain polyglutamic acid copolymer or polylysine copolymer, the initiator is selected from n-hexylamine or triethylamine , the acid anhydride in the amino acid ring is selected from benzyl glutamate-N-carboxylic acid anhydride or benzyloxycarbonyl-lysine-N-carboxylic acid anhydride;

[0059] B) Mix the polyglutamic acid copolymer obtained in step A) with the coupling reagent and the compound having the structure of formula (III) to undergo a condensation reaction to obtain a polyglutamic acid graft copolymer; or mix the polyglutamic acid graft copolymer obtained in step A) The polylysine copolymer is mixed with the coupling reagent and the compound having the structure of formula (IV), and undergoes condensation reaction to obtain the poly...

Embodiment 1

[0131] Dissolve 3.68g (0.02mol) of N-phenyl-1,4-p-phenylenediamine in a mixture of 100mL acetone, 100mL water and 25mL concentrated hydrochloric acid to obtain N-phenyl-1,4-p-phenylenediamine mixed solution, and frozen to 0°C; then weighed 4.56g (0.02mol) of ammonium persulfate (APS) and dissolved it in 50mL of 1mol / L HCl aqueous solution to obtain an APS solution, and slowly dropped the APS solution into N-phenyl-1 , in the 4-p-phenylenediamine mixture (dropped in about half an hour), reacted for 3 hours after dropping, then filtered to obtain a solid, and then washed the solid with 0.6mol / L HCl aqueous solution and acetone, and filtered with 0.5mol / L The solid was back-doped with L ammonia water, and finally the solid was washed three times with water to neutrality, freeze-dried and then vacuum-dried to obtain aniline tetramers whose terminal groups were amino groups. The yield was 80%.

Embodiment 2

[0133] Dissolve 3.5g of N-(4-anilino)-1,4-p-phenylenediamine and 2.6g of N,N-diphenyl-1,4-p-phenylenediamine in 100mL N,N-dimethylformaldehyde A mixture of N-(4-anilino)-1,4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine was obtained from a mixture of amide, 15mL water and 15mL concentrated hydrochloric acid, and freeze to 0°C; then weigh 2.28 g (0.01 mol) of ammonium persulfate APS and dissolve it in 50 mL of 1 mol / L HCl aqueous solution to obtain an APS solution, slowly drop the APS solution into N-(4-anilino)-1 , in the mixture of 4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine (dropped in about half an hour), react for 1 hour after dropping, and then pour the product into 700mL of water for Precipitate, filter to obtain a solid, wash the solid three times with 0.1mol / L HCl aqueous solution and water successively, then back-dope the solid with 0.1mol / L ammonia water, and finally wash the solid three times with water once until neutral, freeze-dry an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides grafted copolymer which is provided with a structure represented by the formula (1) or the formula (II). The grafted copolymer has good water solubility and good electrochemistry response characteristics due to the fact that the grafted copolymer is provided with electroactive aniline oligomer segments. Prepared grafted copolymer is adsorbed to the surfaces of materials which are subjected to preprocessing layer by layer so as to obtain the layer-by-layer decorative materials which have an adjustable composite layer number and good electroactivity. The layer-by-layer decorative materials, used as biomedical polymer materials, can be better applied to the field of tissue engineering like artificial organs or tissue repair representing by the formula (1) or the formula (II).

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials, in particular to a graft copolymer, its preparation method and a layer-by-layer modification material. Background technique [0002] Tissue engineering has made great progress in seed cells, three-dimensional scaffold materials, bioactive factors, tissue construction, implantation in vivo, etc., and has good industrialization prospects. The patient's treatment brought light. [0003] The three important factors of tissue engineering are materials, cells and signals. Scientific issues such as how to achieve the best interaction between materials and cells, and how materials and signals affect cell behavior have become research hotspots. It has been found that modifying and functionalizing the surface of traditional materials can greatly improve and regulate cell proliferation and differentiation. Therefore, various surface modification methods such as laser etching, plasma s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G69/48C08G69/10B32B27/34
Inventor 陈学思崔海涛刘亚栋庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com