Grafted copolymer and preparation method thereof and layer-by-layer decorative materials

A graft copolymer and modified material technology, applied in the field of graft copolymer, its preparation method and layer-by-layer modified materials, can solve the problems of no electrical activity, etc., achieve good water solubility, good composite layers, good electrical Effect of Chemical Response Properties

Active Publication Date: 2013-06-05
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the tissue engineering materials

Method used

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  • Grafted copolymer and preparation method thereof and layer-by-layer decorative materials
  • Grafted copolymer and preparation method thereof and layer-by-layer decorative materials
  • Grafted copolymer and preparation method thereof and layer-by-layer decorative materials

Examples

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Example Embodiment

[0057] The present invention also provides a preparation method of the graft copolymer, including:

[0058] A) The initiator is mixed with the amino acid ring anhydride, the ring-opening polymerization reaction is performed, and then the deprotection is performed to obtain a polyglutamic acid copolymer or a polylysine copolymer. The initiator is selected from n-hexylamine or triethylamine , Said amino acid ring anhydride is selected from benzyl glutamate-N-carboxylic acid anhydride or benzyloxycarbonyl-lysine-N-carboxylic acid anhydride;

[0059] B) The polyglutamic acid copolymer obtained in step A) is mixed with a coupling reagent and a compound having the structure of formula (III) to undergo condensation reaction to obtain a polyglutamic acid graft copolymer; or the polyglutamic acid graft copolymer obtained in step A) The polylysine copolymer is mixed with the coupling reagent and the compound having the structure of formula (IV) to undergo a condensation reaction to obtain a ...

Example Embodiment

[0130] Example 1

[0131] Dissolve 3.68g (0.02mol) of N-phenyl-1,4-p-phenylenediamine in a mixture of 100mL acetone, 100mL water and 25mL concentrated hydrochloric acid to obtain N-phenyl-1,4-p-phenylenediamine mixture And freeze to 0℃; then weigh 4.56g (0.02mol) of ammonium persulfate (APS) and dissolve it in 50mL1mol / L HCl aqueous solution to obtain the APS solution, and slowly drop the APS solution into N-phenyl-1 under ice bath , 4-p-phenylenediamine mixture (dropped in about half an hour), react for 3 hours after dripping, then filter to obtain the solid, and then wash the solid with 0.6mol / L HCl aqueous solution and acetone successively, and use 0.5mol / The solid was counter-doped with ammonia water, and the solid was finally washed with water three times to neutrality, freeze-dried and vacuum dried to obtain the aniline tetramer with amino end groups. The yield is 80%.

Example Embodiment

[0132] Example 2

[0133] Dissolve 3.5g of N-(4-anilino)-1,4-p-phenylenediamine and 2.6g of N,N-diphenyl-1,4-p-phenylenediamine in 100mL N,N-dimethylformaldehyde A mixture of N-(4-anilino)-1,4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine is obtained from a mixture of amide, 15mL water and 15mL concentrated hydrochloric acid, And freeze to 0℃; then weigh 2.28g (0.01mol) of ammonium persulfate APS and dissolve it in 50mL1mol / L HCl aqueous solution to obtain the APS solution, slowly drip the APS solution into N-(4-anilino)-1 under ice bath ,4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine (about half an hour to drip), react for 1 hour after dripping, then pour the product into 700mL water The solid was precipitated and filtered. The solid was washed three times with 0.1mol / L HCl aqueous solution and water in turn, and then the solid was counter-doped with 0.1mol / L ammonia water. Finally, the solid was washed with water three times to neutrality. After lyop...

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Abstract

The invention provides grafted copolymer which is provided with a structure represented by the formula (1) or the formula (II). The grafted copolymer has good water solubility and good electrochemistry response characteristics due to the fact that the grafted copolymer is provided with electroactive aniline oligomer segments. Prepared grafted copolymer is adsorbed to the surfaces of materials which are subjected to preprocessing layer by layer so as to obtain the layer-by-layer decorative materials which have an adjustable composite layer number and good electroactivity. The layer-by-layer decorative materials, used as biomedical polymer materials, can be better applied to the field of tissue engineering like artificial organs or tissue repair representing by the formula (1) or the formula (II).

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials, in particular to a graft copolymer, its preparation method and a layer-by-layer modification material. Background technique [0002] Tissue engineering has made great progress in seed cells, three-dimensional scaffold materials, bioactive factors, tissue construction, implantation in vivo, etc., and has good industrialization prospects. The patient's treatment brought light. [0003] The three important factors of tissue engineering are materials, cells and signals. Scientific issues such as how to achieve the best interaction between materials and cells, and how materials and signals affect cell behavior have become research hotspots. It has been found that modifying and functionalizing the surface of traditional materials can greatly improve and regulate cell proliferation and differentiation. Therefore, various surface modification methods such as laser etching, plasma s...

Claims

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Application Information

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IPC IPC(8): C08G69/48C08G69/10B32B27/34
Inventor 陈学思崔海涛刘亚栋庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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