Cefpodoxime proxetil granules and preparation method thereof

Abstract

The invention relates to cefpodoxime proxetil granules and a preparation method thereof. The granules comprise the following components in parts by weight: 40-60 parts of cefpodoxime proxetil, 700-950 parts of filler, 30-50 parts of disintegrant, 30-50 parts of binder, 12-35 parts of flavoring agent, 2-10 parts of disintegration promoting agent and 1-7 parts of other auxiliary materials. The preparation method of the granules specifically comprises the following steps of: (1) performing pretreatment on the raw materials and the auxiliary materials; (2) mixing; (3) performing granulation; and (4) performing total mixing. The cefpodoxime proxetil granules prepared by the preparation method disclosed by the invention have the advantages of capability of obviously reducing the bitterness of the raw materials, stable preparation, controllable quality, good medicament dissolution and higher safety and effectiveness in clinical medication, and is suitable for industrial mass production and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular, the invention relates to a cefpodoxime axetil granule and a preparation method thereof. Background technique [0002] Cefpodoxime Proxetil (Cefpodoxime Proxetil) is a third-generation oral broad-spectrum cephalosporin, which belongs to β-lactam antibiotics. It was developed by Japan Sankyo Company and was first listed in Japan in 1990. Its trade name is Vantin and its chemical name is (6R , 7R)-7-[2-(2-aminothiazol-4-yl)-(Z)-2-(methoxyimino)acetamido]-3-methoxymethyl-8-oxo-5-sulfur Hetero-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid-1-(isopropoxycarbonyloxy)ethyl ester has the structure of formula I: [0003] [0004] Formula I [0005] Cefpodoxime axetil is a prodrug of cefpodoxime, which itself has no antibacterial activity. It is absorbed through the intestinal tract after oral administration, and is hydrolyzed into cefpodoxime by non-specific esterase in the in...

AI Technical Summary

Problems solved by technology

Moreover, because cefpodoxime axetil is highly stable to β-lactamase, many β-lactamase-producing microorganisms resistant to penicillins and cephalosporins are still sensitive to this product

[0006] Currently, cefpodoxime axetil products on the market are mainly tablets, capsules and dry suspensions, but their use is limited because the main drug is insoluble in water, bitter in taste, and has a peculiar smell.

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