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Implantable kidney-tonifying bone-invigorating traditional Chinese medicine extract-antibiotic-calcium sulfate sustained-release system, and preparation method and application thereof

A technology of invigorating the kidney, strengthening bones, and antibiotics, which is applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., to achieve good application prospects, long-lasting drug effects, and reduce complications

Active Publication Date: 2014-06-25
ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no calcium sulfate sustained-release preparation combined with traditional Chinese medicine ingredients and antibiotics for experimental research and clinical treatment of osteomyelitis

Method used

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  • Implantable kidney-tonifying bone-invigorating traditional Chinese medicine extract-antibiotic-calcium sulfate sustained-release system, and preparation method and application thereof
  • Implantable kidney-tonifying bone-invigorating traditional Chinese medicine extract-antibiotic-calcium sulfate sustained-release system, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The operation steps of the preparation method of icariin-vancomycin-calcium sulfate sustained-release preparation are as follows:

[0046] 1) According to the proportion of the prescription, weigh 9.5g of calcium sulfate carrier, put it in a clean container, and set aside;

[0047] 2) According to the proportion of the prescription, weigh 0.12g of total icariin (the content of icariin is >10% after content determination) and set aside;

[0048] 3) According to the prescription ratio, weigh 0.88g of vancomycin hydrochloride powder injection, add it to the total icariin in step 2), mix well to form a mixture, and set aside;

[0049] 4) Draw 3ml of sterilized physiological saline, add it to the mixture in step 3), dissolve into a clear solution, and set aside;

[0050] 5) Take the solution in step 4), add it to the carrier material in step 1), stir quickly and evenly, and immediately transfer it to the corresponding mold with a spatula, fill it up and remove air bubbles, pl...

Embodiment 2

[0052] The operation steps of the preparation method of icariin-tobramycin-calcium sulfate sustained-release preparation are as follows:

[0053] 1) According to the proportion of the prescription, weigh 9.5g of calcium sulfate carrier, put it in a clean container, and set aside;

[0054] 2) According to the proportion of the prescription, weigh 0.12g of total icariin (the content of icariin is >10% after content determination), 0.6g of sodium alginate, mix well, and set aside;

[0055] 3) Take 3ml of tobramycin sulfate, add it to the mixture of icariin and sodium alginate in step 2), dissolve, and if necessary, conduct ultrasound to promote dissolution into a clear solution, and set aside;

[0056] 4) Take the solution in step 3), add it to the carrier material in step 1), stir quickly and evenly, and immediately transfer it to the corresponding mold with a spatula, fill it up and remove air bubbles, place it for 5-10 minutes, and take it out after it is completely cured; Ob...

Embodiment 3

[0058] The preparation of Example 1 is used for local implant administration of chronic osteomyelitis rabbit model, and the steps include:

[0059] 1) According to the proportion of the prescription, weigh 9.5g of calcium sulfate carrier, put it in a clean container, and set aside;

[0060] 2) According to the proportion of the prescription, weigh 0.12g of total icariin (the content of icariin is >35% after content determination) and set aside;

[0061] 3) According to the prescription ratio, weigh 0.88g of vancomycin hydrochloride powder injection, add it to the total icariin in step 2), mix well to form a mixture, and set aside;

[0062] 4) Draw 3ml of sterilized physiological saline, add it to the mixture in step 3), dissolve the clear solution, and set aside;

[0063] 5) Take the solution in step 4), add it to the carrier material in step 1), stir quickly and evenly, and immediately transfer it to the corresponding mold with a spatula, fill it up and remove air bubbles, p...

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Abstract

The invention especially relates to a kidney-tonifying bone-invigorating traditional Chinese medicine extract-antibiotic-calcium sulfate sustained-release system and a preparation method and application thereof, which belongs to the technical field of an implantable sustained-release administration system. The sustained-release system comprises, by mass, 0.1 to 1.0 part of a kidney-tonifying bone-invigorating traditional Chinese medicine extract, 0.1 to 2.0 parts of an antibiotic and 5 to 20 parts of a calcium sulfate carrier. The invention has the following beneficial effects: a drug effect lasts for a long time; effect-enhancing and toxicity-reducing functions are achieved through combination of Chinese traditional and Western medicine; healing of bone infection diseases is effectively promoted, complications are reduced, and a cure rate is improved.

Description

technical field [0001] The invention belongs to the technical field of implantable sustained-release drug delivery systems, and in particular relates to a Chinese medicine extract-antibiotic-calcium sulfate sustained-release system for nourishing the kidney and strengthening bones and its preparation method and application. Background technique [0002] The incidence of osteomyelitis and other bone defects combined with bone infection is on the rise due to social development, and the treatment is difficult. It is a difficult disease that needs to be solved urgently in the field of surgery. Clinical treatment is based on surgical removal of sequestrum and fibrotic tissue, followed by tissue flap transplantation or bone transplantation, and antibiotic treatment. Because it is difficult for intravenous or oral antibiotics to enter the deep part of the infection to kill bacteria, and the course of the disease is long, long-term use of antibiotics is required, which will inevitab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K38/14A61K36/296A61K36/11A61K36/487A61K36/21A61K36/39A61K36/185A61K47/02A61K47/36A61P19/08A61P31/04
Inventor 寿旦董宇沈立锋张扬黄孝闻王绪平俞忠明李洪玉
Owner ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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