Traditional Chinese medicine composition having anti-lung cancer and anti-liver cancer effects

An anti-lung cancer and composition technology, applied in the field of traditional Chinese medicine compositions, can solve problems such as undiscovered anti-lung cancer and liver cancer effects, achieve good inhibitory effect, simple preparation process, and improve spleen index and liver index.

Active Publication Date: 2013-06-26
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the patent of the traditional Chinese medicine composition (CN101152408A) of Paeoniae saponins and Astragalus polysaccharides has been reported, but no traditional Chinese medicine composition has been found that has anti-lung and liver cancer effects and is composed of Paeoniae saponins, turmeric polysaccharides, and white peony extracts. thing

Method used

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  • Traditional Chinese medicine composition having anti-lung cancer and anti-liver cancer effects
  • Traditional Chinese medicine composition having anti-lung cancer and anti-liver cancer effects
  • Traditional Chinese medicine composition having anti-lung cancer and anti-liver cancer effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Take 1 g of the commercially available Chonglou extract (produced by Baoji Fangsheng Biological Development Co., Ltd.) powder with a specification of 10:1 after passing through an 80-mesh sieve.

[0023] (2) Preparation of turmeric polysaccharide

[0024] 1) Crush 300g of turmeric medicinal materials into small pieces, then add them to absolute ethanol and soak for 1 hour, the dosage ratio of medicinal materials to absolute ethanol is 1g: 9.5mL, then heat and reflux at 90°C for 1 hour, discard Remove the extract and keep the reflux residue;

[0025] 2) Add the above-mentioned reflux residue to water, the ratio of reflux residue to water is 1g:9mL, then heat and reflux at 90°C for 2 extractions, each time for 2.5 hours, and combine the 2 extracts;

[0026] 3) The extract obtained above was filtered and then concentrated under reduced pressure to a relative density of 1.0 at 25°C, and then decolorized using macroporous weakly basic anion exchange resin D301-G at 35°C...

Embodiment 2

[0036] (1) Take 10 g of the commercially available Paprika extract powder with a specification of 5:1 after passing through an 80-mesh sieve.

[0037] (2) Preparation of turmeric polysaccharide

[0038] 1) Crush 300g of turmeric medicinal materials into small pieces, then add them to absolute ethanol and soak for 1 hour, the dosage ratio of medicinal materials to absolute ethanol is 1g: 9.5mL, then heat and reflux at 90°C for 1 hour, discard Remove the extract and keep the reflux residue;

[0039] 2) Add the above-mentioned reflux residue into water, the ratio of reflux residue to water is 1g:10mL, then heat and reflux at 90°C for 2 extractions, each time for 2.5 hours, and combine the 2 extracts;

[0040] 3) The extract obtained above was filtered and then concentrated under reduced pressure to a relative density of 1.0 at 25°C, and then decolorized using macroporous weakly basic anion exchange resin D301-G at 35°C and pH=5.5;

[0041] 4) Add the above-mentioned decolorized...

Embodiment 3

[0050] (1) Take 10 g of the commercially available Paprika extract powder with a specification of 20:1 after passing through an 80-mesh sieve.

[0051] (2) Preparation of turmeric polysaccharide

[0052] 1) Crush 300g of turmeric medicinal materials into small pieces, then add them to absolute ethanol and soak for 1 hour, the dosage ratio of medicinal materials to absolute ethanol is 1g: 9.5mL, then heat and reflux at 90°C for 1 hour, discard Remove the extract and keep the reflux residue;

[0053] 2) Add the above-mentioned reflux residue into water, the ratio of reflux residue to water is 1g:10mL, then heat and reflux at 90°C for 2 extractions, each time for 2.5 hours, and combine the 2 extracts;

[0054] 3) The extract obtained above was filtered and then concentrated under reduced pressure to a relative density of 1.0 at 25°C, and then decolorized using macroporous weakly basic anion exchange resin D301-G at 35°C and pH=5.5;

[0055] 4) Add the above-mentioned decolorize...

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Abstract

The invention discloses a traditional Chinese medicine composition having anti-lung cancer and anti-liver cancer effects. The traditional Chinese medicine composition is composed of a paris polyphylla extract, turmeric polysaccharides and a radix paeoniae alba extract in a weight ratio of 1: (0.1-5): (1-10). The in-vitro MTT (Methylthiazolyl Tetrazolium) assay activity tests proves that traditional Chinese medicine composition provided by the invention is capable of obviously inhibiting the growth of lung cancer cell lines such as LA795 and liver cancer cell lines such as Hep-B3; and lung adenocarcinoma and hepatocellular carcinoma-bearing mice model tests show that the anti-tumor rates of the traditional Chinese medicine composition both are more than 50%, and the traditional Chinese medicine composition is capable of improving the spleen index and the liver index of the mice, and obviously inhibiting pulmonary metastasis of subcutaneously transplanted tumors of the mice and causing apoptosis of tumor cells without any obvious toxic and side effects. Compared with single use of each raw material, the medicine composition is higher in anti-lung cancer and anti-liver cancer activity and clear in action, and has excellent inhibition effect on the lung cancer and the liver cancer.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition with anti-lung cancer and liver cancer effects, belonging to the technical field of traditional Chinese medicine. Background technique [0002] The traditional Chinese medicine Chonglou is the dried rhizome of Paris polyphylla Smith var. It has the effect of relieving swelling and pain, cooling the liver and relieving convulsions. It is used to treat boils, carbuncles, sore throat, poisonous snake bites, bruises, and convulsions caused by cool wind. The main components of Chinese patent medicines. Modern pharmacological studies have shown that Chonglou has physiological activities such as cytotoxic activity, antibacterial and anti-inflammatory, analgesic, hemostatic, sedative, anti-early pregnancy, spermicide, and effects on the respiratory system and cardiovascular system. , functional uterine bleeding, lymph node tuberculosis ulcer, neurodermatitis, surgical inflammation and tumors...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P35/00C08B37/00A61K31/715
Inventor 高文远张瑶刘振满淑丽李红法
Owner TIANJIN UNIV
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