Composite hydrogel dressing and preparation method thereof
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A technology of composite hydrogel and gel layer, which is applied in the field of medical materials, achieves the effect of wide application prospect, easy operation and short cycle
Inactive Publication Date: 2014-11-26
NANJING 3H MEDICAL PROD CO LTD
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However, small molecule cross-linking agents have certain cytotoxicity, and the emergence of active polymerization provides a new option for the preparation of PEG hydrogel dressings
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Embodiment 1
[0028] Preparation of polyethylene glycol diacrylate
[0029] Add 40.0 g (0.1 mol) of PEG-400 and 17.3 g (0.24 mol) of acrylic acid, 87 mL of dehydrating agent to a three-necked flask equipped with a reflux condenser, thermometer and stirrer Toluene, 0.35 g hydroquinone and p-cresol composite inhibitor, 1.7 g catalyst p-toluenesulfonic acid, stirred, heated by electric heating mantle, reacted at reflux temperature (110-120 ℃) for 4 h, and then Replace the thermometer with a water separator, and divide the water for about 2 hours. When no water evaporates, the reaction is terminated. Distill under reduced pressure to remove the solvent and unreacted acrylic acid to obtain a brownish-yellow liquid product, namely the product polyethylene glycol diacrylate (PEGDA).
[0030]
[0031] The infrared absorption characterization of the resulting PEGDA is as follows figure 2 As shown, curve a in the figure represents the absorption curve of PEGDA, and curve b represents the abso...
Embodiment 2
[0058] Mix PEGDA and water in proportion, add ammonium persulfate (APS) aqueous solution and tetramethylethylenediamine (TEMED) aqueous solution, mix evenly, coat on the mesh high-density polyethylene layer, and polymerize in an oven , to prepare composite hydrogel dressings.
[0059] The properties of the resulting hydrogels are as follows:
[0060] (1) Gel time (Table 7)
[0061]
[0062] As can be seen from the above table 7, the gel time shortens with the increase of the initiator concentration, shortens with the increase of the gel temperature, shortens with the increase of the concentration of the PEG aqueous solution, and decreases with the increase of the molecular weight of the PEG main chain. increased and shortened.
[0063] (2) Equilibrium water content (Table 8)
[0064]
[0065] It can be seen from the above table 8 that the equilibrium water content increases with the increase of the molecular weight of the PEG main chain, decreases with the increase of...
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Abstract
The invention provides composite hydrogel dressing. The composite hydrogel dressing comprises a base material layer and a gel layer which is covered on the base material layer, wherein the base material layer is a net-like high-density polyethylene layer; and the gel layer is a PEG (Polyethylene Glycol) based hydrogel layer. The invention further provides a method for preparing the composite hydrogel dressing. The method comprises the following steps of: (a), enabling the polyethylene glycol and acrylic acid to generate esterification reaction in an organic solvent, and carrying out water separating treatment to obtain polyethylene glycol diacrylate; (b), dissolving the polyethylene glycol diacrylate in water, and uniformly mixing the obtained aqueous solution with an initiator to obtain a mixed solution; and (c), coating the mixed solution on the net-like high-density polyethylene layer to obtain the composite hydrogel dressing through gelation. The composite hydrogel dressing can be used for preparing medicinal wound dressing with excellent performances, which is sufficiently combined with the better mechanical performances of the high-density polyethylene materials with the characteristics of the PEG-based hydrogel. The preparation method of the composite hydrogel dressing is simple in method, easy to operate, safe and environment-friendly, and good in application prospect.
Description
technical field [0001] The invention relates to the field of medical materials, more particularly to a composite hydrogel dressing and a preparation method thereof. Background technique [0002] Skin trauma may cause various damages, such as increased metabolism, decreased body temperature, excessive loss of water and protein, and disorders of the endocrine and immune systems. Wound dressing is a medical material that can temporarily protect wounds, prevent wound contamination, promote healing, and relieve pain. It is an important medical product. In 1962, Professor Winte of the United Kingdom first proposed the theory of moist therapy, and confirmed that compared with the dry wound environment exposed to the air, the moist environment formed after the application of moist and permeable wound dressings can promote the formation of epithelium , to accelerate wound healing. Since then, people have researched and developed various wet dressings to overcome the deficiencies of...
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