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Preparation method of novel medical hydrogel dressing

A hydrogel medical and hydrogel technology, which is applied in the field of preparation of new hydrogel medical dressings, can solve the problems of high temperature resistance of medical accessories, high requirements for production equipment, poor transparency, etc., and achieve short gelation time and swelling Excellent performance and high transparency

Inactive Publication Date: 2013-08-07
NANJING 3H MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the embodiment of the present invention is to provide a preparation method of a new type of hydrogel medical dressing, which aims to solve the problems that the current medical accessories are not resistant to high temperature, have a small degree of swelling, poor transparency, and require high production equipment

Method used

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  • Preparation method of novel medical hydrogel dressing
  • Preparation method of novel medical hydrogel dressing

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preparation example Construction

[0031] Such as figure 1 Shown, the preparation method of the novel hydrogel medical dressing that the embodiment of the present invention provides comprises the following steps:

[0032] Step 1, preparing raw materials for preparing novel hydrogel medical dressings;

[0033] Step 2, adding water-soluble polymers, functional monomers, dehydrating agents, polymerization inhibitors and catalysts into the reactor, and stirring evenly;

[0034] Step 3, heating to reflux, distilling off the solvent and unreacted functional monomers to obtain hydrogel monomers;

[0035] Step 4, mixing the hydrogel monomer with water, adding an initiator, mixing evenly, and coating on the reticular high-density polyethylene;

[0036] Step 5, putting the material obtained in Step 4 into an oven to polymerize to prepare a hydrogel dressing.

[0037] As an optimized solution of the embodiment of the present invention, the novel hydrogel medical dressing comprises the following components as raw materi...

Embodiment 1

[0057] Hydrogel medical dressing, comprising the following components:

[0058] Water-soluble polymer: 20 g of polyethylene glycol; functional monomer: 4 g of acrylic acid; dehydrating agent: 40 g of toluene; polymerization inhibitor: 0.1 g of p-cresol; catalyst: 1.5 g of p-toluenesulfonic acid.

[0059] The preparation method of hydrogel medical dressing, comprises the following steps:

[0060] Step 1, add polyethylene glycol, acrylic acid, toluene, p-cresol and p-toluenesulfonic acid into the reaction kettle, stir evenly, heat to a temperature range of 120 °C, and the reaction time is 3 h, then distill off the solvent and unreacted acrylic acid to obtain hydrogel monomer;

[0061] Step 2, mix the hydrogel monomer with water (3 times the weight of the hydrogel monomer), add the initiator azobisisobutyronitrile (0.5% by weight of the hydrogel monomer), mix well and coat Put it on the mesh material and put it in an oven at 40°C for 1 h to obtain a transparent cross-linked compo...

Embodiment 2

[0064] The dosage of each component of the hydrogel dressing described in this embodiment is as follows:

[0065] Water-soluble polymer: polyethylene glycol 40 g; functional monomer: methacrylic acid 20 g; dehydrating agent: xylene 80 g; polymerization inhibitor: p-cresol, hydroquinone, 0.05 g each; catalyst: p-toluenesulfonic acid 1 g.

[0066] The preparation method of the hydrogel dressing described in the present embodiment comprises the following steps:

[0067] Step 1: Add polyethylene glycol, methacrylic acid, xylene, p-cresol / hydroquinone and p-toluenesulfonic acid into the reaction kettle, stir evenly, heat to 80°C, reflux for 6 h, and then distill Remove solvent and unreacted methacrylic acid to obtain hydrogel;

[0068] Step 2, mixing the hydrogel monomer with water (1.5 times the weight of the hydrogel monomer), adding ammonium persulfate / tetramethylethylenediamine (in equal proportions, the total weight is 0.7 times the weight of the hydrogel monomer) %), mixed...

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Abstract

The invention discloses a preparation method of a novel medical hydrogel dressing. The method comprises the following steps of: preparing a material for preparing the novel medical hydrogel dressing; adding a water-soluble polymer, a functional monomer, a dehydrating agent, a polymerization inhibitor and a catalyst to a reaction kettle to evenly agitate; heating and refluxing, distilling to remove a solvent and unreacted functional monomer to obtain a hydrogel monomer; mixing the hydrogel monomer with water; adding an initiator, coating on net high-density polyethylene after evenly mixing; and putting the material prepared from the step 4 into an oven to polymerize and prepare the hydrogel dressing. According to the method disclosed by the invention, polyethylene glycol (PEG) and the functional monomer are taken as materials; crosslinking polymerized PEG monomer is prepared by alkyd reaction; and the crosslinking polymerized PEG is taken as the monomer; water is taken as medium. Thus, the synthetic novel medical hydrogel dressing is high in transparency, short in gelation time, excellent in swelling behavior, wide in material source, simple in process, safe and nontoxic, and has good development and application prospects.

Description

technical field [0001] The invention belongs to the technical field of manufacturing medical wound repair materials, and in particular relates to a preparation method of a novel hydrogel medical dressing. Background technique [0002] In 1962, Dr. George Winter, a British scientist, proposed wet diagnosis therapy for the first time, keeping the wound moist can relieve pain and promote wound healing. Since then, various new wet dressings have been developed rapidly to overcome the shortcomings of traditional gauze dressings, and hydrogel dressings are one of the more important ones. The main component of the hydrogel dressing is a polymer gel with a three-dimensional network structure, which can absorb wound exudate, keep the wound moist, debride the wound and accelerate wound healing. [0003] At present, the commonly used preparation methods of hydrogel include chemical method, freeze-thaw method, radiation method and so on. Chemical method is the most commonly used metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26C08F299/02C08J7/04A61L15/24A61L15/42C08F120/28
Inventor 朱志阳朱志才胡小红陶小亮黄小玲
Owner NANJING 3H MEDICAL PROD CO LTD
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