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Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof

A technology for a needle cap and a syringe, which is applied to the rubber needle cap for pre-filled syringes and the production field thereof, can solve the problem that the ultraviolet absorbance of the finished product, the reducing substance and the pH change value easily exceed the standard, the production process is complicated and tedious, and the rubber cap is sprayed. Sulfur" and other problems, to achieve the effect of improving lubricity and chemical inertness, reducing odor problems, and increasing the degree and speed of vulcanization

Active Publication Date: 2013-08-07
郑州翱翔医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Rubber needle caps for traditional prefilled syringes use traditional sulfur and zinc oxide accelerator systems of natural rubber or polyisoprene rubber. In order to improve the vulcanization speed, vulcanization degree and vulcanization efficiency, high content of sulfur is usually used Sulfenamide and thiuram accelerators, in the production process, the use of these materials can easily cause the phenomenon of "sulphur spraying" of rubber protective caps, and the UV absorbance, reducing substances and pH changes of the finished products can easily exceed the standard. Therefore, it is usually necessary to use a certain concentration of acid and alkali to carry out high-pressure extraction treatment on the product. The production process is complicated and cumbersome, and it is easy to cause product pollution and environmental pollution.

Method used

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  • Rubber syringe needle protective cap for pre-encapsulation injection syringe and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: A rubber needle protective cap for prefilled syringes, the production steps are as follows: A. Ingredients: Accurately weigh 100 parts by weight of synthetic polyisoprene rubber, 20 parts by weight of MD1250 basic white carbon black, and calcined kaolin 50 parts by weight, 1.0 parts by weight of peroxide, 1.0 parts by weight of stearic acid, 5 parts by weight of polytetrafluoroethylene micropowder, 10 parts by weight of ultra-high molecular weight polyethylene micropowder, 3 parts by weight of titanium dioxide, 0.5 parts by weight of carbon black, for subsequent use .

[0024] B. Internal mixing: Use a powerful pressurized internal mixer with a capacity of 55 liters to mix the weighed raw materials evenly. The internal mixing cycle is 8 minutes, and the actual temperature of the internal mixing rubber is 100-110°C. Glue spare.

[0025] C. Roll out strips: Cut the mixed rubber into strips on the XK-550A open rubber mixing machine, park for 8-24 hours, and mak...

Embodiment 8

[0034] Example 8: A rubber needle shield for prefilled syringes, prepared from the following raw materials in parts by weight: 100 parts of synthetic polyisoprene rubber, 5-30 parts of basic white carbon black, 20-30 parts of calcined kaolin 70 parts, 0.3-1.2 parts of peroxide, 0.5-1.0 parts of stearic acid, 5-20 parts of polytetrafluoroethylene powder, 5-20 parts of ultra-high molecular weight polyethylene powder, 1-5 parts of titanium dioxide, and 0.1 parts of carbon black -3 copies.

[0035] The production steps are as follows:

[0036] A, batching: select raw material according to above-mentioned parts by weight, carry out compounding, weigh standby;

[0037] B. Internal mixing: Use a powerful pressurized internal mixer to mix the prepared raw materials evenly. The internal mixing cycle time is 5-8 minutes. The actual temperature of the internal mixing rubber is 90-110°C, and the mixed rubber is prepared for use ;

[0038] C. Opening and stripping: Cut the mixed rubber ...

Embodiment 9

[0042] Example 9: A rubber needle shield for prefilled syringes, prepared from the following raw materials in parts by weight: 100 parts of synthetic polyisoprene rubber, 10-20 parts of basic white carbon black, 40-20 parts of calcined kaolin 50 parts, peroxide 0.8-1.0 parts, stearic acid 0.7-1.0 parts, polytetrafluoroethylene powder 10-15 parts, ultra-high molecular weight polyethylene powder 10-15 parts, titanium dioxide 3-5 parts, carbon black 0.1 -1 copy.

[0043] Others are the same as embodiment 8.

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Abstract

The invention discloses a rubber syringe needle protective cap for a pre-encapsulation injection syringe. The protective cap is prepared from the following raw materials in parts by weight: 100 parts of synthesized polyisoprene rubber, 5-30 parts of alkaline white carbon black, 20-70 parts of calcined kaolin, 0.3-1.2 parts of peroxide, 0.5-1.0 part of stearic acid, 5-20 parts of polytetrafluoroethylene micro powder, 5-20 parts of ultra-high molecular weight polyethylene micro powder, 1-5 parts of titanium dioxide and 1-3 parts of carbon black. The rubber syringe needle protective cap has the obvious characteristics that a clean and simple peroxide sulfuration system is adopted, and a conventional complicated sulfur and zinc oxide promotion system is avoided. Special alkaline fillers are adopted, the sulfuration degree and speed of rubber are improved, and a smell problem caused by adopting the peroxide to sulfurate the polyisoprene rubber is reduced. The polytetrafluoroethylene micro powder and the ultra-high molecular weight polyethylene micro powder with good inertness and dispersibility are added into a formula, the lubricity and chemical inertness of the rubber are improved, and the viscous resistance of a rubber syringe needle protective cap product is improved.

Description

technical field [0001] The invention belongs to the field of rubber fittings for prefilled syringes, in particular to a rubber needle protective cap for prefilled syringes and a production method thereof. Background technique [0002] Rubber needle caps for traditional prefilled syringes use traditional sulfur and zinc oxide accelerator systems of natural rubber or polyisoprene rubber. In order to improve the vulcanization speed, vulcanization degree and vulcanization efficiency, high content of sulfur is usually used Sulfenamide and thiuram accelerators, in the production process, the use of these materials can easily cause the phenomenon of "sulphur spraying" of rubber protective caps, and the UV absorbance, reducing substances and pH changes of the finished products can easily exceed the standard. Therefore, it is usually necessary to use a certain concentration of acid and alkali to perform high-pressure extraction treatment on the product. The production process is comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L9/00C08L27/18C08L23/06C08K13/02C08K3/36C08K3/34C08K5/14C08K5/09C08K3/22C08K3/04
Inventor 马东风代高峰刘海洪李向阳
Owner 郑州翱翔医药科技股份有限公司
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