Method for preparing traditional Chinese medicine composition for treatment of parkinson's disease

A technology for Parkinson's disease and composition, which is applied in the field of preparation of traditional Chinese medicine compositions to achieve the effect of reducing complications

Inactive Publication Date: 2013-08-14
杨明会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are still some problems with the drug we studied, mainly because its therapeutic act

Method used

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  • Method for preparing traditional Chinese medicine composition for treatment of parkinson's disease
  • Method for preparing traditional Chinese medicine composition for treatment of parkinson's disease
  • Method for preparing traditional Chinese medicine composition for treatment of parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1. The traditional Chinese medicine composition of the present invention

[0025] The composition of the raw materials of the traditional Chinese medicine composition: 200 g of cornus, 100 g of angelica, 150 g of fleece-flower root, 150 g of Cistanche deserticola, 150 g of salvia, 200 g of red peony root, 100 g of chuanxiong, 150 g of astragalus, 100 g of centipede, 80 g of leech, and 100 g of Zhimu.

Example Embodiment

[0026] Example 2. Preparation method of traditional Chinese medicine composition of the present invention

[0027] Preparation method of traditional Chinese medicine composition:

[0028] (1) Weigh the raw materials of the traditional Chinese medicine according to the formula of the traditional Chinese medicine composition of Example 1. First, soak them with 10 times the amount of water for 1 hour, and then decoct and extract twice for 1.5 hours each time. Combine the decoction and concentrate to obtain a concentrated Liquid reserve

[0029] (2) Take the concentrated solution obtained in step (1), add ethanol to make the concentration of ethanol in the concentrated solution reach 70%, stand still, precipitate, take the supernatant, and concentrate to obtain the alcohol precipitation concentrate for use;

[0030] (3) Take the alcohol precipitation concentrate obtained in step (2) and add the diluent cyclodextrin to mix uniformly, sizing and drying to prepare granules.

Example Embodiment

[0031] Example 3. The effect of traditional Chinese medicine composition on superoxide dismutase (SOD) in brain tissue of Parkinson's disease rats

[0032] 1Materials and methods

[0033] 1.1 Animals 40 adult SD rats, female, weighing (210 ± 20) g, all provided by the Medical Laboratory Animal Center of the General Hospital of the People's Liberation Army, in line with the national secondary laboratory animal standards. The animals were tested to confirm no abnormal behavior before the experiment.

[0034] 1.2 Instruments and reagents SN-2 brain stereotaxic instrument made in Japan; micro-injector (10μl) (Shanghai Anting Micro-injector Factory); domestic QL21 small animal rotation monitor (Beijing Academy of Military Sciences); EPS-4105 Model digital double constant electrophoresis instrument (Beijing Liuyi Instrument Factory); DF-23C bridge type horizontal electrophoresis tank (Beijing Liuyi Instrument Factory); XH-B type vortex oscillator (Jiangsu Instrument Factory); Esco ultra-...

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Abstract

The invention relates to a method for preparing a traditional Chinese medicine composition for treatment of parkinson's disease, comprising: (1) weighing pulp of dogwood fruit, angelica sinensis, polygonum multiflorum, herba cistanche, salvia root, and root of common peony, immersing the medicines with water 10-12 times of the medicines for 1-2 hours, decocting and extracting twice, wherein each time lasts for 1-2 hours, adding the decoction liquids together, concentrating to get a concentrated solution for standby; (2) adding alcohol to the concentrated solution obtained in the step (1) until the concentration of alcohol in the concentrated solution reaches 60-80%, standing, depositing, taking supernatant, concentrating to get a alcohol precipitation concentrate for standby, and (3) adding a diluent of cyclodextrin or corn starch to the alcohol precipitation concentrate obtained in the step (2), mixing uniformly, granuling, drying, and preparing into granules to get the traditional Chinese medicine composition. The traditional Chinese medicine composition has a substantial curative effect on treating the parkinson's disease.

Description

1. Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a traditional Chinese medicine composition for treating Parkinson's disease. 2. Background technology [0002] Parkinson's disease (PD) is a common degenerative brain disease in middle-aged and elderly people, characterized by resting tremor, bradykinesia, muscle rigidity and abnormal posture. PD has the characteristics of slow disease progression, long course of disease and high disability rate, and has become a "chronic killer" that threatens the health of middle-aged and elderly people. With the aging population in our country, the number of patients is increasing year by year. Currently, the prevalence of PD is 1.70% for those aged 55-74, 3.40% for those aged 75-84, and 4.07% for those over 85 years old. There are more than 5 million PD patients in the country, which not only seriously affects the physical and mental health of patients, ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/16A61K35/64A61K35/62A61K35/648
Inventor 杨明会李绍旦刘毅窦永起
Owner 杨明会
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