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Preparation method of theaflavin enteric microcapsule, as well as product prepared by preparation method and application of product

A theaflavin, enteric-coated technology, which is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, and applications, can solve the problems of poor stability of theaflavin, narrow application area, low utilization rate, etc. , to achieve the effect of improving poor stability, uniform particle size and low cost

Active Publication Date: 2013-08-21
SHANGHAI KE BAO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the defects of the existing theaflavins such as poor stability, few dosage forms, low utilization rate, and extremely narrow application range, and to provide a preparation method of theaflavins enteric-coated microcapsules and its prepared Products and Applications

Method used

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  • Preparation method of theaflavin enteric microcapsule, as well as product prepared by preparation method and application of product
  • Preparation method of theaflavin enteric microcapsule, as well as product prepared by preparation method and application of product
  • Preparation method of theaflavin enteric microcapsule, as well as product prepared by preparation method and application of product

Examples

Experimental program
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Effect test

Embodiment 1

[0052] raw material:

[0053]

[0054] Its steps include:

[0055] (1) Preparation of the capsule material solution: dissolve the capsule material in 95% ethanol aqueous solution to obtain a 4% capsule material ethanol solution; the 4% is the mass percentage of the capsule material relative to the ethanol aqueous solution; the 95% is the volume percentage that ethanol accounts for solution;

[0056] Preparation of the core material emulsion: dissolve the tea extract containing tea pigment in 5L distilled water to obtain a 2% core material solution; the percentage is the mass percentage of the core material relative to water; add stearic acid,

[0057] Stir and ultrasonically emulsify for 30 minutes; the percentage is the mass percentage of stearic acid in the core material solution.

[0058] (2) Mix the capsule material solution with the core material emulsion and stir evenly; add anti-sticking agent and emulsifier B,

[0059] Stir and emulsify to obtain an emulsion, flu...

Embodiment 2

[0062] raw material:

[0063]

[0064]

[0065] Process steps and conditions:

[0066] (1) Preparation of the capsule material solution: dissolve the capsule material in 95% ethanol aqueous solution to prepare a 5% capsule material ethanol solution; the 5% is the mass percentage of the capsule material relative to the ethanol aqueous solution;

[0067] Preparation of the core material emulsion: dissolve the tea extract containing tea pigment in 2L distilled water to obtain a 5% core material solution; the percentage is the mass percentage of the core material relative to water; add stearic acid, stir, and ultrasonically Emulsifying; said percentage is the mass percentage that stearic acid accounts for core material solution.

[0068] (2) Mix the capsule material solution with the core material emulsion, and stir evenly; add anti-sticking agent and emulsifier B, stir and emulsify to obtain an emulsion, and fluidize the emulsion and spray dry it. The spray drying conditio...

Embodiment 3

[0071]

[0072] Process steps and conditions:

[0073] (1) Preparation of the capsule material solution: dissolve the capsule material in 80% ethanol aqueous solution to prepare a 1% capsule material ethanol solution; the 1% is the mass percentage of the capsule material relative to the ethanol aqueous solution;

[0074] Preparation of the core material emulsion: dissolve the tea extract containing theaflavin into 10L distilled water to obtain a 1% core material solution; the percentage is the mass percentage of the core material relative to water; add stearic acid, stir, Ultrasonic emulsification for 30 minutes; said percentage is the mass percentage of stearic acid in the core material solution.

[0075] (2) Mix the capsule material solution with the core material emulsion, and stir evenly; add anti-adhesive agent and emulsifier B, stir and emulsify to obtain an emulsion, fluidize the emulsion and spray dry, and the conditions for spray drying: the inlet air temperature i...

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Abstract

The invention discloses a theaflavin enteric microcapsule particle, a preparation method and an application thereof. The preparation method comprises the following steps of: (1) dissolving 2-8 parts by weight of a capsule material, which is an enteric material, into a 80%-95% ethanol water solution to prepare 1%-8% capsule material solution, dissolving 0.5-2 parts by weight of theaflavin-containing tea extract into distilled water to obtain 0.15%-2% core material solution, adding 2%-5% of stearic acid into the core material solution, and stirring and emulsifying to obtain a core material emulsion; and (2) mixing the capsule material solution and the core material emulsion, uniformly stirring, adding 0.01-0.1 part by weight of an antisticking agent and 1-8 parts by weight of castor oil and / or span-80 into a mixture, stirring and emulsifying to obtain an emulsion, and drying the emulsion, wherein the weight ratio of the core material to the capsule material is 1:2 to 1:8. A theaflavin enteric microcapsule disclosed by the invention is simple in preparation method and process, good in stability, convenient to store and transport, uniform in granularity, good in dispersibility, high in medicament encapsulation rate and dissolubility and capable of being widely applied to the fields, such as health-care products, medicaments and the like.

Description

technical field [0001] The invention relates to theaflavin enteric-coated microcapsule particles, a preparation method and application thereof. Background technique [0002] Theaflavins are a golden-yellow pigment present in black tea, which is a product of tea fermentation. [0003] Theaflavin is the first compound with definite pharmacological effects found in tea, known as the "soft gold" in tea. After clinical trials, it has been verified that theaflavins have the effects of regulating blood lipids and preventing cardiovascular diseases, and have no toxic and side effects. Theaflavins can not only combine with cholesterol in the intestinal tract to reduce the absorption of cholesterol in food, but also inhibit the body's own synthesis of cholesterol. [0004] At the same time, theaflavins have a strong antioxidant effect. The results of related literature research show that theaflavins have anti-tumor, anti-virus, anti-caries, and antibacterial effects, and also have a...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K36/82A61K47/32A61K47/38A61P3/06A23L1/29A23P1/04A61K31/353A23L33/00A23P10/30
Inventor 赵剑金蓓文常瑞娜
Owner SHANGHAI KE BAO BIOTECH CO LTD
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