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Preparation method of ginkgo leaf essence

A technology of Ginkgo biloba extract and Ginkgo leaf, which is applied in the field of preparation of Ginkgo biloba extract refined product Ginkgo biloba extract, can solve the problems of many inorganic chemical media, high cost, complicated process, etc., to improve the stability of properties and increase the content And the effect of easy control of proportion and process

Active Publication Date: 2013-08-21
中意九州生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, many organic and inorganic chemical media are used, the process is complicated, the cost is high, and it is easy to cause residue, which affects the quality of the product.
At present, the production technology of Ginkgo biloba extract in China is mainly extracted by water or alcohol solvent, and then adsorbed by macroporous resin (Chinese Patent Application No. 94114835.1), but its acquisition rate is low, and the content of the obtained extract is also low. high

Method used

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  • Preparation method of ginkgo leaf essence

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Get Ginkgo biloba 100kg, with 40% ethanol 12,10,10 times the amount (referring to raw material weight and solution volume ratio, continued embodiment is the same as this). Dipping and stirring at 80°C for three times, each time for 2 hours, release the extract, combine and concentrate to a small volume, add 5 times the amount of purified water to dilute, add 5 times the amount of purified water after rough separation of the drug solution at 0°C or - Settle at 1°C. The supernatant was passed through styrene-type macroporous adsorption resin (AB-8), washed with 2 times the volume of the resin, eluted with 20% ethanol, and then 70% ethanol to collect the eluate. The resin can be reused after regeneration. The eluate was concentrated under reduced pressure, then dried under reduced pressure, and the temperature was controlled to be ≤75°C to obtain 2.4kg of ginkgo leaf extract containing 26.5% ginkgo flavonol glycosides and 8.5% ginkgo terpene lactones, of which 4.2% biloba...

Embodiment 2

[0028] Take 200kg of ginkgo leaves and crush them into coarse powder, use 10, 6, and 5 times the amount of 75% ethanol, and extract three times at 70°C for 3 hours each time, release the extract, combine and concentrate to a small volume, and add 8 times the amount of purified water After dilution, the medicinal solution is roughly separated and then added with purified water to make the volume up to 1600L, and it is left to settle at a temperature of 20°C. The supernatant was passed through a styrene-type macroporous adsorption resin column (DM-130), washed with 2 times the resin volume of purified water, eluted with 30% ethanol, then 95% ethanol, and the eluate was collected. The resin can be reused after regeneration. The eluate was concentrated under reduced pressure at a temperature of less than 75°C, and then spray-dried to obtain 4.6 kg of ginkgo leaf extract containing flavonol glycosides ≥ 28%, ginkgolidene ≥ 9%, and bilobalide as high as 4.5%.

Embodiment 3

[0030] Take 200kg of ginkgo leaves and crush them into coarse powder, use 9, 7, and 5 times the amount of 85% ethanol, and extract three times at 70°C for 3 hours each time, release the extract, combine and concentrate to a relative density of 1.20 at 70°C, add 8 times Dilute with a certain amount of purified water, and then add purified water to make the volume to 1600L after crude separation, and let it settle at a temperature of 20°C. The supernatant was passed through a styrene-type macroporous adsorption resin column (DM-130), washed with 2 times the resin volume of purified water, eluted with 25% ethanol, and then 90% ethanol to collect the eluate. The resin can be reused after regeneration. eluent with CO 2 Supercritical fluid drying, the conditions are: drying temperature 40°C, pressure 15MPa, CO 2 The flow rate is 20kg / h, and 5.2kg of ginkgo leaf extract containing flavonol glycosides ≥ 28%, ginkgolidene ≥ 10% and bilobalide as high as 4.5% are obtained.

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Abstract

The invention relates to a preparation method of ginkgo leaf essence. The preparation method comprises the following steps of: extracting ginkgo leaves by hydrous ethanol for a plurality of times, concentrating an extracting solution, recovering a solvent, diluting the concentrated solution by water or purified water, cooling the diluted solution at the temperature below 20 DEG C, precipitating, taking supernate, absorbing the supernate by a macroporous resin column, carrying out elution by an alcoholic solution for twice, and drying the eluant to obtain the ginkgo leaf essence. In the preparation method, the used medium does not contain or contains less harmful substance residues; the method is easy in technology control and high in extraction yield; and the product is high in content of active ingredients and stable in quality.

Description

technical field [0001] The invention relates to a technology for extracting medicinal components of natural plants, in particular to a method for preparing ginkgo leaf essence, a refined product of ginkgo leaf extract. Background technique [0002] Ginkgo biloba is one of the oldest tree species in the world and is known as a "living fossil". Ginkgo leaves are the leaves of Ginkgo biloba. Ginkgo biloba leaves are sweet, bitter and astringent in nature, beneficial to the heart and lungs, reducing dampness and relieving diarrhea. "Chinese Medicine Chronicle" records that it can "contract lung qi, relieve asthma and cough, and stop turbidity". According to modern pharmacological research, ginkgo biloba has a wide range of effects on the human body, such as improving cardiovascular and peripheral vascular circulation, improving myocardial ischemia, promoting memory, and improving brain function. In addition, Ginkgo biloba extract (GBE) has a very strong antioxidant effect, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K127/00
Inventor 崔海影
Owner 中意九州生物科技有限公司
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