Method for preparing porous polymer material by selective biodegradation

A technology for porous polymers and degradable polymers, which is applied in the field of selective biodegradation to prepare porous polymer materials, which can solve the problems of unfavorable application of human tissue scaffolds, poor connectivity between pores, and cytotoxicity, so as to avoid cytotoxic hazards, Good mechanical properties, controllable pore size and porosity

Active Publication Date: 2015-06-10
吉林省开顺新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the technical problems that the preparation method of the porous polymer material in the prior art causes the material to be poisonous to the cells, the connectivity between the pores is poor, and it is not conducive to the application as a human tissue scaffold, and to provide a selective biological Method for preparing porous polymer materials by degradation

Method used

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  • Method for preparing porous polymer material by selective biodegradation
  • Method for preparing porous polymer material by selective biodegradation
  • Method for preparing porous polymer material by selective biodegradation

Examples

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Embodiment 1

[0064] Method for preparing porous polymer material through selective biodegradation:

[0065] (1) Both PLA and PP were placed in a vacuum oven and dried under vacuum at 80°C for 24 hours. Weighed 18g of PLA and 42g of PP, and carried out melt blending in an internal mixer (HaakeRheomix600, Karlsruhe, Germany) to obtain a blended material. The blending conditions are: temperature 175°C, rotation speed 50 rpm, time 5-8 minutes;

[0066] (2) After preparing the sample of the blended material, put the sample into a sterile room for ultraviolet irradiation for 20 minutes, then put it into a 250ml Erlenmeyer flask containing 100ml of hydrochloric acid buffer solution (pH=8.6), and add proteinase K at the same time, After marking, put it on a shaker at 37°C (140r / min), and when the PLA component on the brittle section of the sample is completely degraded (the quality remains constant), take out the sample;

[0067] (3) Rinse the sample with distilled water and dry to constant weigh...

Embodiment 2

[0069] Method for preparing porous polymer material through selective biodegradation:

[0070] (1) Place PCL and PE in a vacuum oven and dry them under vacuum at 40°C and 80°C for 24 hours respectively, weigh 24g of PCL and 36g of PE, and carry out melt blending in an internal mixer (HaakeRheomix600, Karlsruhe, Germany) to obtain a blend For mixing materials, the blending conditions are: temperature 140°C, speed 50 rpm, time 5-8 minutes;

[0071] (2) After preparing the sample of the blended material, put the sample into a sterile room for ultraviolet irradiation for 20 minutes, then put it into a 250ml Erlenmeyer flask containing 100ml of phosphate buffer solution (pH=7.0), and add Rhizopus aeruginosa (Rhizopus arrhizus), after marking, put it on a shaking table at 30°C (140r / min), and when the PCL component on the brittle section of the sample is completely degraded (the quality remains constant), take out the sample;

[0072] (3) Rinse the sample with distilled water and d...

Embodiment 3

[0074] Method for preparing porous polymer material through selective biodegradation:

[0075] (1) Place PCL, PLA, and PE in a vacuum oven at 40°C, 80°C, and 80°C for 24 hours in a vacuum, and then weigh 24g of PCL, 12g of PLA, and 24g of PE in an internal mixer (Haake Rheomix600, Karlsruhe, Germany). Melt-blending in a medium to obtain a blended material, the blending conditions are: temperature 175°C, rotating speed 50 rpm, time 5-8 minutes;

[0076] (2) After preparing the sample of the blended material, put the sample into a sterile room for ultraviolet irradiation for 20 minutes, then put it into a 250ml Erlenmeyer flask containing 100ml of phosphate buffer solution (pH=7.0), and add Rhizopus aeruginosa After marking, put it on a shaking table at 30°C (140r / min). When the PCL component on the brittle section of the sample is completely degraded (the quality remains constant), take out the sample, wash it and dry it to a constant weight, and then put it in Add proteinase ...

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Abstract

The invention discloses a method for preparing a porous polymer material by selective biodegradation, belongs to the technical field of a biodegradable high molecular material, and solves the technical problems of a preparation method of the porous polymer material in the prior art that poisons are caused to cells, the connectivity between holes is poor and the porous polymer material cannot be used as a human tissue bracket. The method disclosed by the invention comprises the following steps of: commixing a biodegradable polymer and a non-biodegradable polymer or commixing various biodegradable polymers to obtain a commixed material; and then, carrying out selective degradation on the biodegradable polymers in the commixed material by utilizing the selectivity of a microorganism or an enzyme to obtain the porous polymer material. The preparation method disclosed by the invention is simple in process, moderate, clean and environment-friendly, and strong in selectivity; and the holes of the prepared porous polymer material are controllable and the porous polymer material can be used as a human tissue bracket material.

Description

technical field [0001] The invention relates to a method for preparing porous polymer materials through selective biodegradation, and belongs to the technical field of biodegradable polymer materials. Background technique [0002] Porous polymer materials, such as polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly-β-hydroxybutyrate (PHB) and their copolymers, due to their unique microporous structure , large specific surface area, good thermal performance and ionization performance, in recent years, has been widely used in gas adsorption, catalyst carrier, filter adsorption, biological tissue material substitutes and environmental science and so on. [0003] The preparation methods of porous polymer materials mainly include solvent casting / particle leaching method, fiber bonding method, gas foaming method, etc. The pore size and porosity of porous materials prepared by solvent casting / particle leaching method are controllable, but prone to Particle...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/26C08L23/12C08L23/06
Inventor 韩立晶琚丹丹李凡韩常玉边俊甲张会良陈珊董丽松
Owner 吉林省开顺新材料有限公司
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