Target SERS (Surface Enhanced Raman Scattering) probe with pH-sensitive drug release characteristic, and preparation method thereof
A probe and sensitive technology, applied in the field of medicine and biology, can solve problems such as photobleaching, restricted application, spectral overlap, etc., and achieve the effect of increasing translocation and increasing savings
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Embodiment 1
[0028] A targeted SERE probe with pH-sensitive drug release characteristics has a core-shell structure, and the probe sequentially includes a gold nanoparticle core labeled with Raman molecules, a silica intermediate layer, and a mesoporous diatom core from the inside to the outside. A shell layer of a silicon oxide layer, a pH-sensitive polymer layer, and a targeting ligand on the surface of the shell layer, the pH-sensitive polymer layer is a chitosan / polymethacrylic acid layer, and the targeting ligand is transferrin . The Raman molecule is 4-mercaptobenzoic acid (4MBA) molecule. The mesoporous silica layer is loaded with drug doxorubicin (DOX). The structure of the targeted SERE probe is spherical, its particle size is 120nm, and its shell thickness is 80nm.
[0029] figure 1 Shown is that the targeted SERS probe with pH-sensitive drug release characteristics has a core-shell structure, the core body is gold nanoparticles, the middle silica layer and mesoporous silica l...
Embodiment 2
[0037] A targeted SERE probe with pH-sensitive drug release characteristics has a core-shell structure, and the probe sequentially includes a gold nanoparticle core labeled with Raman molecules, a silica intermediate layer, and a mesoporous diatom core from the inside to the outside. A shell layer of a silicon oxide layer, a pH-sensitive polymer layer, and a targeting ligand on the surface of the shell layer, the pH-sensitive polymer layer is a chitosan / polymethacrylic acid layer, and the targeting ligand is transferrin . The Raman molecule is 5,5-dithiobis(2-nitrobenzoic acid) molecule. The mesoporous silicon dioxide layer is loaded with drug mitoxantrone. The targeted SERE probe structure is spherical, its particle size is 160 nm, and its shell thickness is 120 nm.
[0038] Using 5,5-dithiobis(2-nitrobenzoic acid) molecule as SERS marker, mitoxantrone as drug molecule, transferrin as targeting ligand to recognize tumor cells, targeting SERE probe The preparation method co...
Embodiment 3
[0045] It is basically the same as Example 1, except that the targeted SERE probe has a spherical structure, a particle size of 140 nm, and a shell thickness of 100 nm.
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