Functionalized unnatural amino acids with quaternary carbon centers and biocatalytic desymmetrization preparation method thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF CHEM CHINESE ACAD OF SCI
- Publication Date
- 2013-09-11
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a functionalized non-natural amino acid with a quaternary carbon center and a biocatalytic desymmetry preparation method thereof. Background technique
[0002] Amino acid compounds are the most widely existing compounds in living organisms, and are important components of living organisms, which play a very important role in the process of life. Because of its similar structure to natural amino acids, unnatural amino acids can often be used as substitutes for natural amino acids to study the role of different amino acids in life processes. Unnatural amino acids have shown certain promise as synthetic raw materials for some growth factor receptor proteins. drug activity. Currently commercialized unnatural amino acids include 2-Amino-2-methyl-3-phenylpropanoic acid (sold by Pure Chemistry Scientific Inc, USA) and 2-Amino-2-methyl-4-pentenoic acid (sold by hexagon labs, USA) .
[0003] Biocatalysis is by far the most efficient,...