A kind of cefdinir dispersible tablet and preparation method thereof
A technology for cefdinir and dispersible tablets, applied in the field of cefdinir dispersible tablets and preparation thereof, can solve the problems of affecting the dissolution rate of cefdinir, slow disintegration and dissolution, low bioavailability and the like, and achieves increased bioavailability. , Stable efficacy and good reproducibility
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Embodiment 1
[0047] A kind of cefdinir dispersible tablet comprises the following components by weight:
[0048] Table 1. Embodiment a group of distribution ratio
[0049] components
Weight (parts)
cefdinir
100
80
50
Crospovidone
10
5
2
[0050] A kind of preparation method of cefdinir dispersible tablet comprises the following steps (each component consumption is as described in table 1):
[0051] 1) Micronization: Cefdinir is pulverized, and the particle size is controlled at d 50 ≤30μm, d 90 ≤60μm, d 100 ≤75μm;
[0052] 2) Mixing: Add mannitol, microcrystalline cellulose and crospovidone, mix evenly, wet granulate, pass through a 16-mesh sieve, and dry to obtain granules, then add aspartame and magnesium stearate to mix Uniform;
[0053] 3) Tablet compression: Cefdinir dispersible tablets were prepared.
Embodiment 2
[0055] A kind of cefdinir dispersible tablet comprises the following components by weight:
[0056] Table 2. Embodiment two groups distribution ratio
[0057]
[0058]
[0059] A kind of preparation method of cefdinir dispersible tablet, comprises the following steps (each component consumption is as described in table 2):
[0060] 1) Micronization: Cefdinir is pulverized, and the particle size is controlled at d 50 ≤30μm, d 90 ≤60μm, d 100 ≤75μm;
[0061] 2) Mixing: add mannitol and croscarmellose sodium, mix evenly, wet granulate, pass through a 18-mesh sieve, and dry to obtain granules, then add aspartame and magnesium stearate and mix evenly;
[0062] 3) Tablet compression: Cefdinir dispersible tablets were prepared.
Embodiment 3
[0064] A kind of cefdinir dispersible tablet comprises the following components by weight:
[0065] Table 3. Embodiment three groups distribution ratio
[0066] components
Weight (parts)
cefdinir
100
80
20
aspartame
5
Magnesium stearate
2
[0067]A kind of preparation method of cefdinir dispersible tablet, comprises the following steps (each component consumption is as described in table 3):
[0068] 1) Micronization: Cefdinir is pulverized with an airflow mill, and the particle size is controlled at d 50 ≤10μm, d 90 ≤20μm, d 100 ≤25μm;
[0069] 2) Mixing: Add mannitol and hydroxypropyl cellulose, mix evenly, wet granulate, pass through a 16-mesh sieve, and dry to obtain granules, then add aspartame and magnesium stearate and mix evenly;
[0070] 3) Tablet compression: Cefdinir dispersible tablets were prepared.
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