Pharmaceutical composition and composite burn cream for treating burns and scalds and preparation method thereof

A composition and drug technology, which can be used in drug combinations, medical raw materials derived from birds, and resistance to vector-borne diseases, etc., can solve the problem of promoting muscle growth without particularly obvious effects.

Inactive Publication Date: 2013-10-23
SHENZHEN BROSTIGER BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, most of the existing traditional Chinese medicine products have no particularly obvious effect on promoting muscle growth, but are mainly reflected in anti-inflammatory and analgesic effects.
On the other hand, the long-term abuse of antibiotics has led to more and more drug-resistant bacteria that cause inflammation (such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, hemolytic streptococcus, etc.), which also makes resistant The successive emergence of medicinal bacteria has become a thorny problem in the treatment of burns and scalds

Method used

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  • Pharmaceutical composition and composite burn cream for treating burns and scalds and preparation method thereof
  • Pharmaceutical composition and composite burn cream for treating burns and scalds and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: Preparation of ultra-pure egg butter

[0048] Select fresh eggs, separate the egg yolk stock solution after breaking the shell; dry it at a temperature of 45-65°C; grind it into egg yolk powder with a particle size of 15-45 mesh; put the egg yolk powder into the extraction kettle, and pass in the extractant carbon dioxide The flow rate is 15-25kg / h, the extraction pressure is 30-50MPa, the extraction temperature is 35°C, and the extraction time is 4-10 hours; the extracted mixture is passed into a decompression separator, and the bottom is settled to separate the ultra-pure egg yolk Oil.

[0049] At present, the preparation process of ultra-pure egg yolk is relatively mature, and many methods similar to the above-mentioned embodiments can achieve the purpose of preparing ultra-pure egg yolk in the present invention. The present invention does not specifically limit the method for preparing ultra-pure egg yolk. A skilled person can select a suitable method...

Embodiment 2

[0050] Example 2: Preparation of bacterial protein antigen for immunization

[0051] (1) Culture of bacteria:

[0052] Staphylococcus aureus (ATCC26031) was activated by streaking on the solid plate of ordinary broth medium, and a single colony after activation was picked and inoculated in ordinary broth medium, and shaken at 37°C for 6-12 hours; Streak activation of Pseudomonas aeruginosa (ATCC27853) on the plate, pick the activated single colony and inoculate it in Sabouraud medium, shake and culture at 37°C for 6-12 hours; use serum broth medium solid plate streak activation Escherichia coli (ATCC25922 ), pick the activated single colony and inoculate it in the serum broth medium, shake culture at 37°C for 6-12 hours; use hexadecanetrimethylammonium bromide medium solid plate to streak and activate the beta-hemolytic streptococcus ( CMCC32210), pick the activated single colony and inoculate it in hexadecanetrimethylammonium bromide medium, and culture it with shaking at 37...

Embodiment 3

[0055] Embodiment 3: Immunization laying hen

[0056] (1) Preparation of mixed antigen:

[0057] Mix the bacterial protein antigens of the above-mentioned Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and hemolytic streptococcus at a concentration ratio of 1:1:1:1 to obtain a mixed antigen, and the final concentration of the mixed antigen is 50-500 μg / ml, stored at -80°C for future use.

[0058] It should be noted that in the present invention, any one or a combination of at least two of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and hemolytic streptococcus can be used as an antigen to immunize laying poultry. However, in order to obtain a better bacteriostatic effect, it is preferable to use a mixture of the above four bacteria as a mixed antigen to immunize laying poultry. The mixing ratio of the above four bacteria can be determined empirically, but the present invention preferably mixes according to the concentration ratio of 1:1:1...

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Abstract

The invention discloses a pharmaceutical composition and composite burn cream for treating burns and scalds and a preparation method thereof. The pharmaceutical composition or the composite burn cream comprises ultra-pure yolk oil and immunoglobulin of yolk with effective treatment dosages, as well as optional pharmaceutically acceptable auxiliary materials, wherein the antigen of the immunoglobulin of yolk is the mycoprotein of one or at least two of staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and hemolytic streptococcus. The composite burn cream can be used for effectively promoting skin regeneration, inhibiting one or at least two of staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and hemolytic streptococcus, and preventing occurrence of infection.

Description

technical field [0001] The invention relates to the field of drugs for treating burns and scalds, in particular to a pharmaceutical composition for treating burns and scalds, a compound burn ointment and a preparation method thereof. Background technique [0002] Burns and scalds are a kind of universal accidental injuries that people are prone to in life. In the case of relatively serious burns and scalds, such as third-degree burns and scalds, the skin and even muscles will be severely damaged. In the process of treatment, on the one hand, it is necessary to promote the regeneration of new skin as much as possible, on the other hand, it is also necessary to prevent the infection of pathogenic microorganisms, reduce or even eliminate the occurrence of inflammation. Typical pathogenic microorganisms that are likely to cause infection include: Staphyloccocus aureus, Pseudomonas aeruginosa, Escherichia coli, Hemolytic streptococcus, etc. [0003] At present, most burn ointmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61P17/02A61K35/54A61K35/57
CPCY02A50/30
Inventor 卢超祁振强
Owner SHENZHEN BROSTIGER BIO PHARMA
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