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Method for separating and purifying high-purity 3,2'',6''-tri-N-acetyl-gentamicin C1a alkali (P1)

A separation and purification, high-purity technology, applied in chemical instruments and methods, chemical recovery, organic chemistry, etc., can solve the problems of high consumption of water and eluent, high environmental pressure, low production yield, etc., and achieve resin utilization. High, floor space saving, production cycle reduction effect

Active Publication Date: 2013-10-30
WUXI JIMIN KEXIN SHANHE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The P1 separated by this traditional separation method has many disadvantages such as low purity, low production yield, large consumption of water and eluent, long cycle, and high pressure on environmental protection.

Method used

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  • Method for separating and purifying high-purity 3,2'',6''-tri-N-acetyl-gentamicin C1a alkali (P1)
  • Method for separating and purifying high-purity 3,2'',6''-tri-N-acetyl-gentamicin C1a alkali (P1)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Combine below figure 1 And the embodiment is described in detail:

[0051] The selected resin of the present invention is a weakly acidic cation exchange resin, the resin is 30 to 80 mesh, and the filling capacity of each resin tank is 0.12m 3 , the size of the resin tank is Φ350×600mm, and the actual filling ratio is 78%. The total size of the system is about 3m×3m×5m (length×width×height).

[0052] Disc transfer type continuous chromatographic separation system separates 3, 2 ", 6 ",-tri-N-acetyl gentamycin C1a base (P1) is divided into the following areas:

[0053] 1) Adsorption area: 1 to 3 units;

[0054] Each unit resin tank in this area is connected in series as a group, controlled by flow rate. The raw material first enters the inlet of No. 3 column, and the liquid flowing out from the outlet of No. 1 column is waste liquid.

[0055] 2) Miscellaneous washing area: units 4 to 7;

[0056] After adsorption, each resin tank needs to be washed with water, locat...

Embodiment 2

[0070] Combine below figure 1 And the embodiment is described in detail:

[0071] The selected resin of the present invention is a weakly acidic cation exchange resin, the resin is 30 to 80 mesh, and the filling capacity of each resin tank is 0.12m 3 , the size of the resin tank is Φ350×600mm, and the actual filling ratio is 78%. The total size of the system is about 3m×3m×5m (length×width×height).

[0072] The simulated moving bed type continuous chromatographic separation system separates 3, 2 ", 6 ",-tri-N-acetyl gentamycin C1a base (P1) is divided into the following areas:

[0073] 1) Adsorption area: 1 to 3 units;

[0074] The feed liquid inlet and waste liquid outlet are located in the adsorption zone. Each unit resin tank in this area is connected in series as a group, controlled by flow rate. The raw material first enters the inlet of No. 3 column, and the liquid flowing out from the outlet of No. 1 column is waste liquid.

[0075] 2) Miscellaneous washing area: ...

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Abstract

The invention relates to a method for separating and purifying high-purity 3,2'',6''-tri-N-acetyl-gentamicin C1a alkali (P1), belonging to the field of semisynthetic chemical pharmacy. The invention utilizes a continuous chromatographic separation technique in combination with a membrane separation technique to obtain the high-purity 3,2'',6''-tri-N-acetyl-gentamicin C1a alkali (P1) from a P1 cobalt removal solution. The method for separating and purifying P1 has the advantages of high yield, low cost and environmental protection, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of semi-synthetic chemical pharmacy and relates to a method for separating and purifying high-purity 3,2", 6"-tri-N-acetyl genta C1a base. Background technique [0002] Aminoglycosides are glycosides formed by linking aminosugar and aminocycloalcohol through an oxygen bridge. There are natural aminoglycosides such as streptomycin from Streptomyces, gentamicin and other natural aminoglycosides from Micromonospora, and semi-synthetic aminoglycosides such as etimicin, all of which are broad-spectrum antibiotics. [0003] Etimicin sulfate (Etimicin sulfate) is a new generation of semi-synthetic aminoglycoside antibiotics with independent intellectual property rights, which is highly efficient, low-toxic, and resistant to drug-resistant bacteria. It is the only one that has obtained the national first-class new drug certificate. Anti-infective drugs. [0004] At present, the techniques used in the production of etimicin ...

Claims

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Application Information

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IPC IPC(8): C07H15/236C07H1/06
CPCY02P20/582
Inventor 姜迎庆
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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