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Starch-derived absorbable medical sponge and preparation method thereof

A starch and sponge technology, applied in the field of medical sponges, achieves the effects of good forming, good hemostatic effect and high adsorption capacity

Active Publication Date: 2014-06-11
JIANGSU DIWO BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention is to provide a starch-type absorbable medical sponge, which can use absorbable starch to prepare a starch sponge with better water absorption and hemostatic properties, without adding animal-derived extracts, and the starch sponge solves the problem of It overcomes the shortcomings of the existing starch sponge texture, which is crisp and brittle. It is loose and porous with uniform pores, and has better hemostatic effect and in vivo degradation rate.

Method used

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  • Starch-derived absorbable medical sponge and preparation method thereof
  • Starch-derived absorbable medical sponge and preparation method thereof
  • Starch-derived absorbable medical sponge and preparation method thereof

Examples

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Effect test

Embodiment 1

[0051] Embodiment 1: A starch-type absorbable medical sponge, comprising a composition with the following mass percentages: 1.5% absorbable starch, 0.0001% foaming agent, and 0.005% humectant. The absorbable starch in this embodiment is pregelatinized starch made from potato starch by screw extrusion method. The foaming agent in this embodiment is Span, and the humectant is propylene glycol.

[0052] Its preparation method is as follows: after adding the Span into purified water, soak it for 1 hour; then use a stainless steel stirrer to stir the soaked Span twice at a low speed of 180 r / min; after the Span is completely dissolved, put the Span in the solution Add propylene glycol, stir 3 times at a medium speed of 300r / min until the solution is uniform, then add pre-gelatinized starch made of potato starch to the solution while stirring until it dissolves evenly to obtain a foaming liquid, and then use a stainless steel stirrer to Stir at a high speed of 700r / min. When the vol...

Embodiment 2

[0053] Embodiment 2: A starch-type absorbable medical sponge, comprising a composition in which the mass percentage of each component is as follows: 12% absorbable starch, 6% foaming agent, and 9% humectant. The absorbable starch in this embodiment is ether starch, the foaming agent in this embodiment is Tween, and the humectant is glycerin.

[0054] The preparation method is as follows: after adding Tween into purified water, soak for 1 hour, put it in a stirrer and stir evenly, then add glycerin to the solution in the stirrer, at a low speed of 180 r / min and at a speed of 300 r / min Stir evenly at a medium speed, then add ether starch to the solution in the agitator while stirring until it dissolves evenly to obtain a foaming liquid, then stir the stainless steel agitator at a high speed of 700r / min until the volume of the foaming liquid expands to the original When the foaming liquid is 4-5 times higher, inject the foaming liquid into the silicone mold tray, put it into the ...

Embodiment 3

[0055] Embodiment 3: A starch-type absorbable medical sponge, including 6% absorbable starch, 2% foaming agent, and 3% humectant. The absorbable starch in this embodiment is acid-modified starch, the foaming agent in this embodiment is glycerin fatty acid ester, and the moisturizing agent is polyethylene glycol 400.

[0056]The preparation method is as follows: add glycerin fatty acid ester to purified water and soak for 1 hour, then put it in a blender and stir evenly, then add polyethylene glycol 400 to the solution in the blender, and stir evenly at a medium speed of 300r / min , then add acid-modified starch to the solution in the stirrer while stirring to dissolve evenly to obtain a foaming liquid, then make the stainless steel stirrer stir at a high speed of 600r / min, until the volume of the foaming liquid expands to the original 4- When the time is 5 times, inject the foaming liquid into the silicone mold tray, put it into the quick-freezing box as soon as possible, and m...

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Abstract

The invention discloses a starch-derived absorbable medical sponge and a preparation method thereof. The starch-derived absorbable medical sponge is a composition comprising the following components by mass percent: 0.08-12% of absorbable starches, 0.0001-6% of foaming agents and 0.005-9% of moisturizing agents. According to the preparation method, the absorbable starches are utilized to prepare the starch sponge with better water-absorbing property and hemostasis property, and zoogenous extracts are unnecessary to be added. The starch sponge overcomes the defect that the existing starch sponge has fragile texture, and the starch sponge is loose and porous and has uniform holes and better hemostatic effect and internal degradation rate.

Description

technical field [0001] The invention relates to the field of medical sponges, in particular to a starch-type absorbable medical sponge and a preparation method thereof. Background technique [0002] In various surgical operations, reducing bleeding and shortening operation time have an important impact on patients after recovery. In recent years, the medical absorbable hemostatic sponge used in the body has attracted great attention from the medical and industrial circles of various countries. The sponge needs to meet the following requirements: 1. Good biocompatibility, cell compatibility and tissue compatibility. Biocompatibility refers to a property of the response of living organism tissues to active materials. For medical sponges to be implanted in the body, at least the reaction that occurs must be accepted by the host without harmful toxic effects. 2. Good biodegradability. The medical sponge undergoes hydrolysis, enzymatic hydrolysis and other processes in the hum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/20A61L31/04A61L27/20C12M3/00C12N5/00
Inventor 贾峻峰
Owner JIANGSU DIWO BIOLOGICAL PROD
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