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Preparation method of magnesium phosphate medical bone adhesive

A technology of bone cement and magnesium phosphate, applied in chemical instruments and methods, applications, medical science and other directions, can solve the problem of low bonding strength of magnesium phosphate medical bone cement, and achieve controllable curing time and mechanical properties. Good, low exothermic effect

Inactive Publication Date: 2013-11-27
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method of magnesium phosphate medical bone cement, which solves the problem that the bonding strength of the magnesium phosphate medical bone cement prepared by the existing preparation method is not high

Method used

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  • Preparation method of magnesium phosphate medical bone adhesive
  • Preparation method of magnesium phosphate medical bone adhesive
  • Preparation method of magnesium phosphate medical bone adhesive

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preparation example Construction

[0026] The preparation method of magnesium phosphate medical bone cement of the present invention is specifically implemented according to the following steps:

[0027] Step 1, first put the medical grade MgO in the crucible, then place the MgO and the crucible together in an energy-saving rapid heating resistance furnace, and calcinate the MgO at a high temperature at a calcination temperature of 1300-1600°C, and keep the temperature for 3-6 hours. Then dry-grind and pulverize in a planetary ball mill to a powder with a particle size of 0-20 μm;

[0028] Step 2, the KH 2 PO 4 Place it in a drying oven at a drying temperature of 120°C for more than 24 hours, then dry grind it in a planetary ball mill to a powder with a particle size of 0-20 μm;

[0029] Step 3, the additive is prepared into a dilute solution with a concentration of 1.0-10.0% and stirred evenly to obtain a solid-phase blended solution A, the solvent is deionized water, normal saline, glucose solution or a dil...

Embodiment 1

[0034] The preparation method of existing magnesium phosphate medical bone cement, concrete steps are as follows:

[0035] Step 1, first put the medical grade MgO in the crucible, then put the MgO and the crucible together in an energy-saving fast heating resistance furnace, calcinate the MgO at a high temperature of 1500°C, keep it warm for 3 hours, and then use the planetary type Ball mill dry grinding to powder with a particle size of 10 μm;

[0036] Step 2, the KH 2 PO 4 Place in a drying oven at a drying temperature of 120°C, dry for 24 hours, and then use a planetary ball mill to dry grind to a powder with a particle size of 20 μm;

[0037] Step 3, mix the MgO powder obtained in step 1 with the KH obtained in step 2 2 PO 4 The powders are mixed evenly to obtain mixture A, wherein, MgO powder and KH 2 PO 4 The substance ratio of the powder is 5:1; then add deionized water to the mixture A while stirring to obtain the slurry B, wherein the mass ratio of the mixture A...

Embodiment 2

[0039] Step 1, first put the medical grade MgO in the crucible, then put the MgO and the crucible together in an energy-saving fast heating resistance furnace, calcinate the MgO at a high temperature of 1500°C, keep it warm for 3 hours, and then use the planetary type Ball mill dry grinding to powder with a particle size of 10 μm;

[0040] Step 2, the KH 2 PO 4 Place in a drying oven at a drying temperature of 120°C, dry for 24 hours, and then use a planetary ball mill to dry grind to a powder with a particle size of 20 μm;

[0041] Step 3, mixing lactic acid and deionized water to prepare a dilute solution with a concentration of 1.0% and stirring evenly to obtain a solid-phase blended solution A;

[0042] Step 4, the MgO powder obtained in step 1 and the KH obtained in step 2 2 PO 4 Mix the powder evenly to obtain mixture B, in which, MgO powder and KH 2 PO 4 The substance ratio of the powder is 5:1; then add the solid phase blending liquid A to the mixture B while sti...

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Abstract

A preparation method of a magnesium phosphate medical bone adhesive concretely comprises the following steps: 1, calcining medical MgO, and carrying out dry grinding to obtain powder having a granularity of 0-20mum; 2, placing KH2PO4 in a drying box, drying at 120DEG C for above 24h, and carrying out dry grinding to obtain powder having a granularity of 0-20mum; 3, processing an additive to prepare a dilute solution having a concentration of 1.0-10.0%, and uniformly stirring to obtain a solid phase mixed solution A; and 4, uniformly mixing the MgO powder obtained in step 1 with the KH2PO4 powder obtained in step 2 to obtain a mixture B, adding the mixture B to the solid phase mixed solution A while stirring to obtain a slurry C, and continuously stirring the slurry C for 1min to obtain the magnesium phosphate medical bone adhesive. The preparation which allows the additive to be added into the solid phase mixed solution obviously improves the adhesive strength of the prepared magnesium phosphate medical bone adhesive.

Description

technical field [0001] The invention belongs to the technical field of adhesive preparation, and relates to a preparation method of magnesium phosphate medical bone adhesive. Background technique [0002] In the clinical treatment of severe comminuted fractures, it is often difficult to use mechanical fixation due to the small bone fragments, which has become one of the problems that plague medical workers. Metal materials and physically bonded ceramic materials have become traditional bone substitute materials due to their excellent mechanical properties, but metal materials have poor biological activity, and will cause metal ions to dissolve under long-term action of body fluids, resulting in cell toxicity; while traditional ceramic materials are highly brittle , Difficult to process, need pre-sintered molding, difficult to match the shape of the bone defect, so these materials are likely to cause problems such as stress shielding, foreign body rejection and non-biodegrada...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/34A61L24/02
Inventor 王爱娟张姣李均明
Owner XIAN UNIV OF TECH
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