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C3 polypeptide supramolecular helical polymer and preparation method thereof

A supramolecular and polymer technology, applied in the field of C3 polypeptide supramolecular helical polymer and its preparation, can solve the problems of expensive raw materials and lack of functionalization of molecules, and achieve the effects of simple preparation, reliable chirality and low price

Inactive Publication Date: 2013-11-27
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the designed molecules lack functionalization and the raw materials are expensive

Method used

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  • C3 polypeptide supramolecular helical polymer and preparation method thereof
  • C3 polypeptide supramolecular helical polymer and preparation method thereof
  • C3 polypeptide supramolecular helical polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take 2.50 mg of C 3 -GA monomer was added into 10 mL of tetrahydrofuran, and then ultrasonic and heated repeatedly until the monomer was completely dissolved. The solution was then left for 12 hours.

Embodiment 2

[0043] take multiple copies of C 3 -AG monomer, 2.5 mg each, was added to 10 mL of methanol, 10 mL of propanol, 10 mL of isopropanol, 10 mL of n-butanol, 10 mL of sec-butanol and 10 mL of tetrahydrofuran, and then Repeated sonication and heating until the monomer is completely dissolved. The solution was then left for 12 hours.

Embodiment 3

[0045] Take 2.50 mg of C 3 -VG monomer was added into 10 mL of tetrahydrofuran, and then ultrasonic and heated repeatedly until the monomer was completely dissolved. The solution was then left for 12 hours.

[0046] Performance Tests and Uses

[0047] The circular dichroism of the above solutions was measured by circular dichroism (CD). Through the CD spectrum ( Figure 4 ) It can be seen that C 3 The tetrahydrofuran solution of -GA monomer showed negative and positive peaks at 243 nm and 215 nm, respectively, confirming that C 3 - The supramolecular helical polymer formed by layer-by-layer self-assembly of GA monomers has a right-handed helix, and the atomic force microscope (see Figure 7 ), observed that C 3 -GA assemblies are multi-strand winding fibers with helices.

[0048] C 3 THF solution of -AG monomer ( Figure 4 ) have negative, positive and negative peaks at 260 nm, 245 nm and 212 nm, respectively, proving that the supramolecular polymer has a left-hande...

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Abstract

The invention provides a C3 polypeptide supramolecular helical polymer and a preparation method thereof. The polypeptide supramolecular helical polymer is prepared through the following steps: a monomer molecule is prepared through the amidation of the pentafluorophenol active ester of trimesic acid and dipeptide modified by an alkyl chain; then the monomer molecule self-assembles into the supramolecular helical polymer in a solution; the chirality of the supramolecular helical polymer can be changed by changing the sequence of amino acid; and the screw pitch of the supramolecular helical polymer can be adjusted by changing the size of the chirality of the amino acid. The supramolecular helical polymer is simple to prepare, a chiral resource (amino acid) adopted is obtained through natural proteolysis and is not synthesized artificially, the chirality is reliable, the price is cheap, the supramolecular helical polymer can be applied to the field of chiral recognition, chiral separation and the like, and the invention provides a new method for preparing novel chiral materials.

Description

technical field [0001] The invention relates to a supramolecular helical polymer and a preparation method thereof. especially a C 3 Polypeptide supramolecular helical polymer and its preparation method. Background technique [0002] Helical polymers have attracted extensive attention from the scientific community for their unique optical activity. The study of helical polymers is not only of theoretical significance, but also the study of the conditions for helix formation, the conditions that affect the helical pitch, and the conditions for helical chirality reversal are of great importance for the understanding of gene expression and gene expression in the biological world. Mutation and protein denaturation are of inestimable value, and helical polymers can be used for chiral recognition, chiral separation, and chiral catalysis. Supramolecules are small molecules that self-assemble into macromolecular polymers with regular structures through weak interactions such as hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C07K5/062C07K1/02
Inventor 张阿方代玉堂王芳
Owner SHANGHAI UNIV
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