Compound containing Lafutidine and preparation containing Lafutidine

A technology of lafutidine and its composition, which is applied in the field of lafutidine preparations, can solve the problems of poor absorption and poor water solubility of lafutidine, and achieve excellent results

A technology of lafutidine and its composition, which is applied in the field of lafutidine preparations, can solve the problems of poor absorption and poor water solubility of lafutidine, and achieve excellent results

CN103417513BActive Publication Date: 2014-12-31YOUCARE PHARMA GROUP +1
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  • Compound containing Lafutidine and preparation containing Lafutidine
  • Compound containing Lafutidine and preparation containing Lafutidine
  • Compound containing Lafutidine and preparation containing Lafutidine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: lafutidine capsules

[0033] 1. Composition: Lafutidine 5kg, lactose 106kg, Tween-803kg, hydroxypropyl cellulose 4kg, talcum powder 55kg.

[0034] 2. Preparation method:

[0035] 1) Pulverize lafutidine, pass through a 100-mesh sieve, and set aside;

[0036] 2) Grind talcum powder, lactose, and hydroxypropyl cellulose separately, and pass through an 80-mesh sieve;

[0037]3) Weigh each component according to the composition, mix the main drug and auxiliary materials for 15-20 minutes by equal amount addition method, and fill 3# capsules.

Embodiment 2

[0038] Embodiment 2: lafutidine capsules

[0039] 1. Composition: Lafutidine 5kg, lactose 120kg, Tween-803kg, hydroxypropyl cellulose 5kg, talcum powder 60kg.

[0040] 2. Preparation method:

[0041] 1) Pulverize lafutidine, pass through a 100-mesh sieve, and set aside;

[0042] 2) Grind talcum powder, lactose, and hydroxypropyl cellulose separately, and pass through an 80-mesh sieve;

[0043] 3) Weigh each component according to the composition, mix the main drug and auxiliary materials for 15-20 minutes by equal amount addition method, and fill 3# capsules.

Embodiment 3

[0044] Embodiment 3: lafutidine capsules

[0045] 1. Composition: Lafutidine 5kg, lactose 85kg, Tween-802kg, hydroxypropyl cellulose 3kg, talc 50kg.

[0046] 2. Preparation method:

[0047] 1) Pulverize lafutidine, pass through a 100-mesh sieve, and set aside;

[0048] 2) Grind talcum powder, lactose, and hydroxypropyl cellulose separately, and pass through an 80-mesh sieve;

[0049] 3) Weigh each component according to the composition, mix the main drug and auxiliary materials for 15-20 minutes by equal amount addition method, and fill 3# capsules.

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Abstract

The invention relates to a compound containing Lafutidine and a preparation containing Lafutidine. The compound comprises Lafutidine, lactose, tween-80, hydroxypropyl cellulose and talcum powder. Compared with the prior art, the compound is evidently faster in capsule dissolution rate and low in impurity content. In addition, the results of various detection of the compound meet the specification.

Description

technical field [0001] The invention relates to the field of lafutidine preparations, in particular to a composition containing lafutidine and a preparation containing the same. Background technique [0002] Peptic ulcer is a common chronic and recurrent digestive system disease. It is the result of the invasive factors of the gastrointestinal mucosa exceeding the defense ability of the mucosa's own protective factors. Its incidence rate accounts for about 10% of the total population. Peptic ulcer can occur in any part of the gastrointestinal tract that is in contact with acidic gastric juice, and the main diseased sites are the stomach and duodenum, with an incidence rate of 98%, and the number of patients with duodenal ulcer is far greater in patients with gastric ulcer. [0003] The formation of peptic ulcers is related to the digestion of gastric acid and pepsin, as well as local mucosal damage (ulcer-causing) factors of the stomach and duodenum (including gastric acid,...

Claims

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Application Information

Patent Timeline
31 Dec 2014
Publication
CN103417513B
IPC
A61K9/48; A61K31/4545; A61K47/26; A61K47/38; A61K47/04; A61P1/04
Inventors
李琦; 杨磊