Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound anti-AIDS pharmaceutic preparation

A pharmaceutical preparation and anti-AIDS technology, applied in antiviral agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of poor drug stability and achieve rapid onset, drug stability, and good dissolution effects

Inactive Publication Date: 2013-12-04
UNIV OF SHANGHAI FOR SCI & TECH +1
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of this, the object of the present invention is to provide a kind of compound anti-AIDS pharmaceutical preparation and preparation method thereof, to solve the problem of the drug in the anti-AIDS pharmaceutical composition containing lamivudine, zidovudine, nevirapine in the prior art. The problem of poor stability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound anti-AIDS pharmaceutic preparation
  • Compound anti-AIDS pharmaceutic preparation
  • Compound anti-AIDS pharmaceutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Compound anti-AIDS drug tablet, its prescription consists of:

[0076] Nevirapine: 200g;

[0077] Zidovudine: 300g;

[0078] Lamivudine: 150g;

[0079] Polyethylene glycol 6000: 20g;

[0080] Methylcellulose: 20g;

[0081] Lactose: 15g;

[0082] Pregelatinized starch: 15g;

[0083] Sodium carboxymethyl starch: 20g;

[0084] Sodium carboxymethylcellulose: 7g;

[0085] Magnesium stearate: 15g;

[0086] Micronized silica gel: 8g.

[0087] During preparation: the first step is to crush polyethylene glycol 6000, pass through a 200-mesh sieve, and mix nevirapine, lamivudine, zidovudine, methylcellulose, lactose, sodium carboxymethyl starch, carboxymethylcellulose The plain sodium is pulverized respectively, passed through a 80-mesh sieve, and set aside; the second step is to place the raw materials and auxiliary materials in the first step in a high-speed stirring granulator, mix well, and set aside; the third step is to mix the ingredients in the second step The un...

Embodiment 2

[0089] Compound anti-AIDS drug preparation (tablet), its prescription consists of:

[0090] Nevirapine: 200g;

[0091] Zidovudine: 300g;

[0092] Lamivudine: 150g;

[0093] Polyethylene glycol 6000: 10g;

[0094] Methylcellulose: 15g;

[0095] Mannitol: 40g;

[0096] Low-substituted hydroxypropyl cellulose: 15g;

[0097] Magnesium Stearate: 5g.

[0098] Preparation: The first step is to pulverize polyethylene glycol 6000, pass through a 200-mesh sieve, and pulverize nevirapine, lamivudine, zidovudine, methylcellulose, mannitol, and low-substituted hydroxypropyl cellulose , through a 80-mesh sieve, and set aside; the second step is to place the raw materials and auxiliary materials in the first step in a high-speed stirring granulator, mix them, and set aside; the third step is to mix the materials in the second step, and pass through Dry granulation, the granules are sized with a 16-mesh sieve; the fourth step is to add magnesium stearate to the granulated granules in t...

Embodiment 3

[0100] Compound anti-AIDS drug tablet, its prescription consists of:

[0101] Nevirapine: 200g;

[0102] Zidovudine: 300g;

[0103] Lamivudine: 150g;

[0104] Polyethylene glycol 6000: 45g;

[0105] Methylcellulose: 50g;

[0106] Lactose: 313g;

[0107] Pregelatinized starch: 200g;

[0108] Stevia: 32g;

[0109] Sodium hydroxymethylcellulose: 15g;

[0110] Magnesium Stearate: 15g.

[0111] During preparation: the first step is to crush polyethylene glycol 6000, pass through a 200-mesh sieve, and mix nevirapine, lamivudine, zidovudine, methylcellulose, lactose, pregelatinized starch, hydroxymethylcellulose Sodium and stevioside are pulverized separately, passed through 80 mesh sieves, and set aside; the second step is to place the raw materials and auxiliary materials in the first step in a high-speed stirring granulator, mix well, and set aside; the third step is to mix them in the second step The material mixed in the process is dry granulated, and the granules are g...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of pharmaceutic preparations, and discloses a compound anti-AIDS pharmaceutic preparation with high drug stability and dissolvability. The compound anti-AIDS pharmaceutic preparation is prepared from the following ingredients: zidovudine, lamivudine, nevirapine, methylcellulose, polyethylene glycol 6000, proper disintegrating agents, lubricant, filler and the like. The compound anti-AIDS pharmaceutic preparation has the advantages that the drug stability and the dissolvability are high; the onset is rapid; the carrying and the drug administration are convenient.

Description

technical field [0001] The invention relates to a compound anti-AIDS pharmaceutical preparation and a preparation method thereof. Background technique [0002] Among the various methods of treating AIDS, "cocktail therapy" has become a standard anti-AIDS prescription. It uses 3 to 4 kinds of drugs at the same time, aiming at different links in the HIV reproduction cycle, so as to achieve the purpose of comprehensively inhibiting or killing HIV and curing AIDS. After treatment with cocktail therapy, HIV in some patients can remain in the body for a long time below the limit. Compound anti-AIDS drug preparations used in "cocktail therapy" generally include antiretroviral drugs, protease inhibitor drugs, etc. Among these drug combinations, the triple compound preparation consisting of nevirapine, zidovudine, and lamivudine has definite curative effects and is one of the "cocktail therapy" combination drugs recommended by the World Health Organization. [0003] However, due t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7072A61K31/551A61K31/513A61P31/18
Inventor 刘哲鹏潘风施与群
Owner UNIV OF SHANGHAI FOR SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com