Preparation process of peritoneal dialysate with physiologic pH value

A peritoneal dialysis solution and preparation technology, which is applied in the direction of medical preparations containing active ingredients, blood diseases, extracellular fluid diseases, etc., can solve the problems of failure to reach, low pH value of the dialysate, etc., to improve the service life, Prolonged treatment time, reduced formation and deposition effects

Active Publication Date: 2013-12-18
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the pH value of the dialysate is low, which cannot rea...

Method used

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Embodiment 1

[0051] A specific embodiment of the preparation process of the peritoneal dialysate of a physiological pH value of the present invention, including raw material preparation and preparation process, the preparation of the raw materials is by weight ratio:

[0052] Liquid A:

[0053] Calcium concentration is 1.25mmol / L

[0054] Anhydrous glucose 27.2g

[0055] Sodium chloride 10.76g

[0056] Calcium chloride 0.366g

[0057] Magnesium chloride 0.1016g

[0058]Appropriate amount of water for injection

[0059] Full volume 1000ml

[0060] Liquid B:

[0061] Sodium Lactate 8.96g

[0062] Appropriate amount of water for injection

[0063] Full volume 1000ml

[0064] Described preparation process is:

[0065] Add fresh water for injection with a temperature of 40°C and 60% of the prescription amount into the preparation container, add glucose, sodium chloride, calcium chloride, magnesium chloride (A liquid) or sodium lactate (B liquid) according to the prescription amount, s...

Embodiment 2

[0067] A specific embodiment of the preparation process of the peritoneal dialysate of a physiological pH value of the present invention, including raw material preparation and preparation process, the preparation of the raw materials is by weight ratio:

[0068] Liquid A:

[0069] Calcium concentration is 1.25mmol / L

[0070] Anhydrous glucose 45.4g

[0071] Sodium chloride 10.76g

[0072] Calcium chloride 0.366g

[0073] Magnesium chloride 0.1016g

[0074] Appropriate amount of water for injection

[0075] Full volume 1000ml

[0076] Liquid B:

[0077] Sodium Lactate 8.96g

[0078] Appropriate amount of water for injection

[0079] Full volume 1000ml

[0080] Described preparation process is:

[0081] Add fresh water for injection with a temperature of 60°C and 70% of the prescription quantity into the preparation container, add glucose, sodium chloride, calcium chloride, magnesium chloride (A liquid) or sodium lactate (B liquid) according to the prescription amount...

Embodiment 3

[0083] A specific embodiment of the preparation process of the peritoneal dialysate of a physiological pH value of the present invention, including raw material preparation and preparation process, the preparation of the raw materials is by weight ratio:

[0084] Liquid A:

[0085] Calcium concentration is 1.25mmol / L

[0086] Anhydrous glucose 77.2g

[0087] Sodium chloride 10.76g

[0088] Calcium chloride 0.366g

[0089] Magnesium chloride 0.1016g

[0090] Appropriate amount of water for injection

[0091] Full volume 1000ml

[0092] Liquid B:

[0093] Sodium Lactate 8.96g

[0094] Appropriate amount of water for injection

[0095] Full volume 1000ml

[0096] Described preparation process is:

[0097] Add fresh water for injection with a temperature of 80°C and 80% of the prescription quantity into the preparation container, add glucose, sodium chloride, calcium chloride, magnesium chloride (A liquid) or sodium lactate (B liquid) according to the prescription amount...

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PUM

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Abstract

The invention provides a preparation process of peritoneal dialysate with a physiologic pH value. The process comprises raw material proportioning and a preparation process. The process is characterized in that the preparation process comprises the following steps: adding fresh water for injection into a proportioning container; inputting glucose, sodium chloride, calcium chloride, and magnesium chloride in prescription amount; after stirring and dissolving, adding water for injection to full dose to prepare a liquid A; adding fresh water for injection into another proportioning container; inputting sodium lactate; after stirring and dissolving, adding water for injection to full dose to prepare a liquid B; after uniformly stirring; respectively adding a pH adjustor into the liquid A and the liquid B to adjust the liquid medicine to appropriate pH values; after pre-filtering and terminal-filtering, respectively filling the liquid A and the liquid B to two chambers of a double-chamber transfusion bag in volume ratio of 1:1; plugging; sterilizing by water bath; sterilizing to obtain the peritoneal dialysate with low glucose degradation products and the physiologic pH value, wherein the pH value of the mixture of the liquid A and the liquid B reaches 6.8-7.4.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a solution for peritoneal dialysis suitable for patients with renal failure, in particular to a process for preparing a peritoneal dialysis solution with a physiological pH value. Background technique [0002] Peritoneal dialysis, as a method for the treatment of end stage renal disease (ESRD), has been widely used due to its special advantages such as easy operation, reduction of blood-borne disease transmission, and protection of residual renal function. Successful peritoneal dialysis depends primarily on a well-functioning peritoneum. Many factors can cause damage to this natural semipermeable membrane, such as peritonitis, relatively poor biocompatibility of peritoneal dialysate, and intraperitoneal use of various drugs, etc., which can lead to pathological changes in the peritoneum, including permeability changes, ultrafiltration failure, etc. , decreased defense ability, su...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K31/19A61K9/08A61P7/08A61K31/7004A61J1/10
Inventor 陈红妍
Owner HUAREN PHARMACEUTICAL CO LTD
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