Carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, as well as preparation method and application thereof

A carboxymethyl cellulose and amphiphilic polymer technology, which is applied in the fields of polymer chemistry and renewable resources, can solve the problems affecting the preparation of amphiphilic cellulose derivative nanomicelles, low degree of hydrophobization and controllability It can achieve the effect of good anti-dilution stability, process safety and high transfer efficiency

Active Publication Date: 2013-12-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such systems have disadvantages such as low controllability, inhomogeneous reaction, and low degree of

Method used

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  • Carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, as well as preparation method and application thereof
  • Carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, as well as preparation method and application thereof
  • Carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Accurately weigh 10g of chloride-1-allyl-3-methylimidazolium ionic liquid (AmimCl) into a 50ml three-neck flask, heat and dissolve in an oil bath at 80°C, add 1g of carboxymethylcellulose under stirring conditions, Introduce nitrogen, stir at 80°C for 8h, and heat up to 120°C after the carboxymethyl cellulose is dissolved. After the temperature is stable, add the reaction monomer lactide L-LA (the molar ratio of lactide to carboxymethyl cellulose basic sugar unit is 2:1) and stannous octoate (the mass percentage of lactide is 0.2% ), under nitrogen protection, and reacted for 24h under magnetic stirring (1000rpm). The reaction was terminated, and the temperature of the system was lowered to room temperature. Pour the mixture in the reactor into 250ml ethanol to make it precipitate, filter the precipitate, and wash 5 times with absolute ethanol to remove unreacted lactide, remaining catalyst and ionic liquid. The product was extracted in acetone at 75°C for 24h, and dr...

Embodiment 2

[0038] Accurately weigh 10g of chloride-1-allyl-3-methylimidazolium ionic liquid (AmimCl) (1-butyl-3-methylimidazolium chloride or 1-(2-hydroxyethyl)- 3‐Methylimidazolium chloride salt) was placed in a 50ml three-necked flask, heated and dissolved in an oil bath at 120°C, 2g of carboxymethylcellulose was added under stirring conditions, nitrogen was introduced, stirred at 120°C for 6h, and the carboxymethylcellulose After the element was dissolved, the temperature was raised to 120°C. After the temperature is stable, add the reaction monomer lactide L-LA (the molar ratio of lactide to carboxymethyl cellulose basic sugar unit is 3:1) and stannous octoate (the mass percentage of lactide is 0.3% ), under nitrogen protection, and reacted for 20h under magnetic stirring (1000rpm). The reaction was terminated, and the temperature of the system was lowered to room temperature. Pour the mixture in the reactor into 250ml ethanol to make it precipitate, filter the precipitate, and was...

Embodiment 3

[0041] Accurately weigh 10g of chloride-1-allyl-3-methylimidazolium ionic liquid (AmimCl) (1-butyl-3-methylimidazolium chloride or 1-(2-hydroxyethyl)- 3-Methylimidazolium chloride salt) was placed in a 50ml three-necked flask, heated and dissolved in an oil bath at 100°C, 1g of carboxymethylcellulose was added under stirring conditions, nitrogen was introduced, stirred at 100°C for 7h, and the carboxymethylcellulose After the element was dissolved, the temperature was raised to 130°C. After the temperature stabilizes, add the reaction monomer lactide L-LA (the molar ratio of lactide to carboxymethyl cellulose basic sugar unit is 4:1) and stannous octoate (the mass percentage of lactide is 0.4% ), under nitrogen protection, and reacted for 18h under magnetic stirring (1000rpm). The reaction was terminated, and the temperature of the system was lowered to room temperature. Pour the mixture in the reactor into 250ml ethanol to make it precipitate, filter the precipitate, and wa...

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Abstract

The invention discloses a carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, as well as a preparation method and an application thereof. The method comprises the following steps: dissolving carboxymethyl cellulose in an ionic liquid to form a homogeneous solution; adding grafting monomers, namely L-lactide monomers and a catalyst, namely stannous octoate into the homogeneous solution; controlling the temperature at 100 DEG C-130 DEG C, performing magnetic stirring, reacting for 18-24 hours in the presence of nitrogen, stopping the reaction and reducing the temperature of a system to room temperature; pouring the reaction system into ethanol to produce a precipitate, filtering and separating the precipitate, and washing with anhydrous ethanol; performing extraction on an obtained product in acetone, and performing vacuum drying to get the purified carboxymethyl cellulose grafted polylactic acid amphiphilic polymer. A dialysis method is utilized for forming self-assembled nanosphere-like micelles of the carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, the particle size is 30-150nm, the critical micelle concentration is 0.01-0.1g/L and the anti-dilution stability is good.

Description

technical field [0001] The present invention relates to an amphiphilic polymer, in particular to a carboxymethyl cellulose grafted polylactic acid amphiphilic polymer and its preparation method and application of self-assembled nano micelles, which belong to macromolecular chemistry and renewable resource field. Background technique [0002] Amphiphilic polymers can self-assemble in aqueous solution to form nanomicelles with a core-shell structure because they contain both hydrophilic and hydrophobic segments in their molecules. At present, the research on polymer self-assembled nanomicelles mainly focuses on the synthesis of block copolymers. However, the synthesis of such polymer micelles is relatively expensive, non-renewable, and often has poor biocompatibility when applied in the field of biomedicine. There are problems such as toxicity in the body. Amphiphilic polymer micelles based on biodegradable, naturally renewable, and biocompatible natural polymers can overcom...

Claims

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Application Information

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IPC IPC(8): C08B11/12C08G63/08C08G63/85A61K47/38A61K9/107A61P35/00A61K31/337
Inventor 王小慧郭延柱梁梓承
Owner SOUTH CHINA UNIV OF TECH
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