Method for improving ceramic sintering performance by adding a small amount of polylactic acid in artificial bone prepared by laser

A technology of laser sintering and sintering performance, which is applied in the field of bone tissue engineering, can solve problems such as aseptic inflammatory reactions, achieve the effects of improving sintering performance, improving mechanical properties, and avoiding residues

Inactive Publication Date: 2013-12-25
CENT SOUTH UNIV
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However, the degradation products of biopolymer materials are acidi

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  • Method for improving ceramic sintering performance by adding a small amount of polylactic acid in artificial bone prepared by laser
  • Method for improving ceramic sintering performance by adding a small amount of polylactic acid in artificial bone prepared by laser
  • Method for improving ceramic sintering performance by adding a small amount of polylactic acid in artificial bone prepared by laser

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[0020] The specific implementation manner of the present invention will be further described below in conjunction with an embodiment.

[0021] A method for improving the sintering performance of BCP by adding a small amount of PLLA to the porous ceramic artificial bone prepared by laser, using HAP and β-TCP powder at a mass ratio of 1:1, and using a mechanical mixing method to prepare evenly mixed BCP powder. Then, a small amount of PLLA was added to the BCP powder, and a BCP / PLLA mixed powder with a PLLA mass fraction of 1% was prepared by mechanical mixing. The obtained BCP / PLLA mixed powder was placed in a self-developed SLS system, and sintered to prepare porous BCP artificial bone. Among them, the spot diameter is 2mm, the powder coating thickness is 0.2mm, the laser power is 10W, and the scanning speed is 100mm / min. Compared with the BCP artificial bone obtained without adding PLLA, it was found that when 1% PLLA was added to the BCP powder, the microstructure of the ob...

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Abstract

A method for improving ceramic sintering performance by adding a small amount of polylactic acid in an artificial bone prepared by laser belongs to the field of bone tissue engineering. When a selective laser sintering (SLS) technology is used for preparing a porous biphasic calcium phosphate ceramic (BCP) artificial bone, a sintering part has the disadvantages of low density and insufficient mechanical properties, and the invention aiming at the disadvantages provides the method for improving BCP sintering performance by adding 0.1-1% by mass percentage of poly-L-lactic acid (PLLA). The advantages of the method are that: a transient liquid phase introduced by use of low temperature fusion of the PLLA can promote the rearrangement and densification of BCP particles so as to improve BCP sintering performance; the PLLA can be fully oxidized until complete disappearance under reasonable process parameters, PLLA residual in the artificial bone can be avoided, and finally the high-performance porous artificial bone completely made from BCP is prepared. The invention relates to the method for improving calcium phosphate bioceramic laser sintering performance by adding a small amount of a polymer material, and the method has the characteristics of simple operation process, good product performance and wide application range.

Description

technical field [0001] The invention belongs to the field of bone tissue engineering, and in particular provides a method of adding a small amount of poly-L-lactic acid (PLLA) to improve the sintering performance of biphasic calcium phosphate ceramics (BCP) when using selective laser sintering (SLS) technology to prepare porous ceramic artificial bones. Methods. During the sintering process, PLLA undergoes three processes of melting, carbonization and oxidation. The introduction of transient liquid phase by low-temperature melting of PLLA promotes the rearrangement and densification of BCP particles and improves the sintering performance of BCP. And by choosing reasonable process parameters, the PLLA can be fully oxidized until it disappears completely, so that its residue in the artificial bone can be avoided. Finally, a high-performance porous artificial bone composed entirely of BCP was prepared. Background technique [0002] Calcium phosphate bioceramics has good bioc...

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Application Information

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IPC IPC(8): C04B35/634C04B35/447A61L27/56A61L27/12A61L27/10
Inventor 帅词俊彭淑平刘景琳聂毅胡焕隆高成德
Owner CENT SOUTH UNIV
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