Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing molecularly imprinted polymer through silica gel surface coating

A technology of surface coating and molecular imprinting, applied in the direction of chemical instruments and methods, other chemical processes, etc., to achieve the effect of good effect and simple preparation method

Inactive Publication Date: 2015-05-20
三亚哈尔滨工程大学南海创新发展基地
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing literature, there is no separation factor of 3.93 for the resolution of racemic binaphthylamine by surface molecularly imprinted polymers, and the polymer is prepared by silica gel surface coating technology

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing molecularly imprinted polymer through silica gel surface coating
  • Method for preparing molecularly imprinted polymer through silica gel surface coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Method for preparing molecularly imprinted polymers by coating aminopropyl silica gel

[0025] Under the protection of nitrogen, put R-1,1′-binaphthalene-2,2′-diamine and methacrylic acid in a molar ratio of 1 / 4, and 6 mL of a mixed solvent of acetonitrile and chloroform into a 50 mL single-necked flask. Sealing, and pre-polymerizing at -12°C under normal pressure for 8 hours, so that template molecules and functional monomers can fully interact to form template-functional monomer complexes. Then, the template functional monomer complex is coated on the surface of aminopropyl silica gel under normal temperature and pressure, and the solvent is removed by rotary evaporation. And transfer the template-functional monomer complex coated on aminopropyl silica gel to a 100mL two-necked flask, add ethylene glycol dimethacrylate (1.2mL), azobisisobutyronitrile (1.5%), acetonitrile and Chloroform mixed solvent 3mL, nitrogen, remove residual oxygen, seal. Then it was placed ...

Embodiment 2

[0031] 1. Method for preparing molecularly imprinted polymers by coating the surface of ordinary silica gel

[0032] Under the protection of nitrogen, put R-1,1′-binaphthalene-2,2′-diamine and methacrylic acid in a molar ratio of 1 / 4, and 6 mL of a mixed solvent of acetonitrile and chloroform into a 50 mL single-necked flask. Sealing and pre-polymerizing for 8 hours under normal pressure at 18°C, so that template molecules and functional monomers can fully interact to form template-functional monomer complexes. Then, the template functional monomer complex is coated on the surface of ordinary silica gel under normal temperature and pressure, and the solvent is removed by rotary evaporation. And transfer the template-functional monomer complex coated on ordinary silica gel to a 100mL two-necked flask, add ethylene glycol dimethacrylate (1.2mL), azobisisobutyronitrile (1.5%), acetonitrile and chloroform to mix Solvent 3mL, pass through nitrogen, remove residual oxygen, seal. T...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
pore sizeaaaaaaaaaa
separation factoraaaaaaaaaa
Login to View More

Abstract

The invention provides a method for preparing a molecularly imprinted polymer through silica gel surface coating. Under protection of nitrogen, template molecules, a functional monomer and a pore-foaming agent are uniformly mixed according to the ratio of (0.2-2%):(0.1-2%):(99.7-96%); the mixture is subject to prepolymerization for 8-12 h under the normal pressure and under the temperature of -15 to 44 DEG C, so as to form a template-function monomer compound; the template-function monomer compound with the mass ratio of 5-12% is coated onto the silica gel with the mass ratio of 95-88%; after coating, dimethyl propenoic acid glycol ester, azodiisobutyronitrile, and the pore-foaming agent are sequentially added into the compound coated on the surface of the silica gel according to the mass ratio of (3-9%):(0.1-1%):(96.9-90%); the mixture is inflated with nitrogen, and is placed into an oil bath at the temperature of 60 DEG C for polymerization for 12 h; the product is subject to drying and elution, and is screened by a 60-20 micrometer sieve. The polymer can be used as the stationary phase of an HLLC to realize chiral resolution for racemic 1,1'-dinaphthalenes, amino acids and derivatives of the dinaphthalenes.

Description

technical field [0001] The invention relates to a method for preparing molecularly imprinted polymers by coating the surface of silica gel. Background technique [0002] 1,1'-binaphthyl-2,2'-diamine is a very typical C2 axis asymmetric aromatic chemical with unique stereochemical properties, namely molecular axis asymmetry, plane asymmetry, rigidity and flexible. This structure can be considered as an extension of central chirality, which has a strong chiral induction effect, and is an important precursor for the synthesis of chiral ligands, chiral resolving agents and chiral catalysts with C2 asymmetry factors. Therefore, the acquisition of binaphthyldiamine optical isomers is meaningful. At present, the methods for obtaining optical isomers of binaphthyldiamine mainly include chemical resolution, chromatographic resolution, chiral synthesis, and molecular imprinting. These methods are complex and time consuming. The surface molecular imprinting technology is to confine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/281B01J20/30C08F220/06C08F220/56C08F226/06C08F222/14C08J9/28
Inventor 董红星欧依玲郑美侠
Owner 三亚哈尔滨工程大学南海创新发展基地