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Preparation method of thermo-sensitive drug sustained and controlled release mesoporous composite

A composite material, temperature-sensitive technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of complex synthesis process, achieve high drug loading, The effect of controlled release improvement and structural stability

Inactive Publication Date: 2014-01-08
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent CN101941705A reports a temperature-sensitive polymer structure-directing agent to prepare mesoporous SiO 2 The method of this invention has the advantage of removing the structure-directing agent without high-temperature calcination and organic solvent extraction. It is a low-cost green preparation method, but the synthesis process is more complicated

Method used

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  • Preparation method of thermo-sensitive drug sustained and controlled release mesoporous composite

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Synthesis experiment: the mesoporous SiO 2 The nanoparticles were activated at 120°C for 5 hours, placed in a desiccator and cooled to room temperature naturally, and then sealed and stored. Dissolve 0.15g of N-isopropylacrylamide, 0.0024g of N,N'-methylenebisacrylamide, 0.0033g of azobisisobutyronitrile in 3mL of acetone to form a solution, and take 0.15g of activated mesoporous SiO 2 Nanoparticles were added thereinto, and finally heated at 60° C. for 12 h under the protection of nitrogen, cooled to room temperature, filtered, washed, and vacuum-dried to obtain a temperature-sensitive mesoporous composite material.

[0028] Drug adsorption: Dissolve 1.2g of the slightly soluble drug ibuprofen in 30mL of n-hexane, add 0.3g of the synthesized mesoporous composite material into the above solution, stir at 45°C for 48h, filter, wash, and filter the solid Vacuum dried to obtain the drug-loaded sample.

[0029] Drug sustained and controlled release experiment: Take 0.05g ...

Embodiment 2

[0033] Synthesis experiment: the mesoporous SiO 2 The nanoparticles were activated at 120°C for 5 hours, placed in a desiccator and cooled to room temperature naturally, and then sealed and stored. Dissolve 0.15g of N-isopropylacrylamide, 0.0024g of N,N'-methylenebisacrylamide, 0.0017g of azobisisobutyronitrile in 3mL of acetone to form a solution, and take 0.15g of activated mesoporous SiO 2 Nanoparticles were added thereinto, and finally heated at 60° C. for 12 h under the protection of nitrogen, cooled to room temperature, filtered, washed, and vacuum-dried to obtain a temperature-sensitive mesoporous composite material.

[0034] Drug adsorption: Dissolve 1.2g of the slightly soluble drug ibuprofen in 30mL of n-hexane, add 0.3g of the synthesized mesoporous composite material into the above solution, stir at 45°C for 48h, filter, wash, and filter the solid Vacuum dried to obtain the drug-loaded sample.

[0035] The drug-carrying system carries out the sensitive release of...

Embodiment 3

[0037] Synthesis experiment: the mesoporous SiO 2 The nanoparticles were activated at 120°C for 5 hours, placed in a desiccator and cooled to room temperature naturally, and then sealed and stored. Dissolve 0.15g of N-isopropylacrylamide, 0.0048g of N,N’-methylenebisacrylamide, 0.0033g of azobisisobutyronitrile in 3mL of acetone to form a solution, and take 0.15g of activated mesoporous SiO 2 Nanoparticles were added thereinto, and finally heated at 60° C. for 12 h under the protection of nitrogen, cooled to room temperature, filtered, washed, and vacuum-dried to obtain a temperature-sensitive mesoporous composite material.

[0038] Drug adsorption: Dissolve 1.2g of the slightly soluble drug ibuprofen in 30mL of n-hexane, add 0.3g of the synthesized mesoporous composite material into the above solution, stir at 45°C for 48h, filter, wash, and filter the solid Vacuum dried to obtain the drug-loaded sample.

[0039] The drug-carrying system carries out the sensitive release of...

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Abstract

The invention belongs to the technical field of polymer chemistry and inorganic synthesis, and relates to a preparation method of a thermo-sensitive drug sustained and controlled release mesoporous composite. Mesoporous SiO2 microspheres are taken as carriers, and in-situ polymerization is adopted for preparing the mesoporous composite with thermosensitivity. The method includes adding an amides polymerization monomer, a crosslinking agent and an initiating agent into an acetone solvent until being completely dissolved, then adding the mesoporous SiO2 microsphere activated in advance into the mixture, heating in the atmosphere of nitrogen at the temperature of 60 DEG C for 12 hours prior to cooling to the room temperature, and performing suction filtration, washing and vacuum drying to obtain the thermo-sensitive mesoporous composite; adding the thermo-sensitive mesoporous composite into an organic solvent containing a drug, regulating the concentration of the drug, stirring at the temperature of 45 DEG C for 48 hours prior to filtering and washing to obtain a solid, and dying the solid in vacuum at the temperature of 40-60 DEG C. The method has the advantages of simple process, convenience in operation and the like, and the obtained thermo-sensitive drug sustained and controlled release mesoporous composite has the advantages of stable structure, high drug loading capacity, good thermosensitivity, stable drug release rate and the like and can be applied to the field of drug controlled release.

Description

technical field [0001] The invention relates to a preparation method of a temperature-sensitive drug sustained and controlled release mesoporous composite material, specifically, the temperature-sensitive polymer poly-N-isopropylacrylamide or poly-N-isopropylacrylamide hydrophilic Copolymer loading onto mesoporous SiO 2 An organic-inorganic mesoporous composite material formed on the surface of microspheres is used for drug loading and sustained release applications. Background technique [0002] Since Mobil Corporation (Nature.1992,359:710~712; J.Am.Chem.Soc.1992,114:10834~10843) successfully developed the mesoporous M41S family in 1992, because of its large specific surface area and pores The synthesis and application of mesoporous materials have become one of the research hotspots due to the advantages of controllable volume and shape, easy functionalization of the surface and regular pore structure. Poly N-isopropylacrylamide (PNIPAAm) is a typical temperature-sensitiv...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/32A61K31/616A61K31/192
Inventor 孙继红郭月月张燕娜张发谦白诗扬武霞
Owner BEIJING UNIV OF TECH
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