Preparation method of polylactic acid particles

A technology of polylactic acid microparticles and polylactic acid, which is applied in the field of polymer microparticle preparation, can solve the problems of difficult scale-up of pilot scale, complicated preparation process, and numerous influencing factors, and achieve the effect of low equipment requirements, simple operation process and mild conditions

Inactive Publication Date: 2014-01-15
TORAY ADVANCED MATERIALS RES LAB CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of the emulsification-solidification method is that the preparation process is complicated, there are many influencing factors, and the quality is difficult to control. At present, most of them are produced in small batches in the laboratory, and there are certain difficulties in pilot scale-up; in addition, surfactants must be used, so that later The process is cumbersome

Method used

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  • Preparation method of polylactic acid particles
  • Preparation method of polylactic acid particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] In a three-necked flask of 500ml, add 6.0g polylactic acid (D lactic acid mass content 4.25%, model is Ingeo TM Biopolymer 4043D), 5.0g polyvinylpyrrolidone, 92g diethylene glycol dimethyl ether, heated to 140°C, and stirred at a speed of 450rpm until the polymer was dissolved. The temperature of the system was lowered to 60° C., and then 100 g of deionized water was added dropwise to the above system at a rate of 1.67 g / min. After the dropwise addition, the resulting suspension was filtered, washed with 200 g of deionized water, filtered, and the filtrate was vacuum-dried at 45° C. for 12 hours to obtain 2.8 g of white polylactic acid powder with a volume average diameter of 3.5 μm, the particle size distribution index is 1.6, and the oil absorption is 90mL / 100g.

Embodiment 2

[0041] In a three-necked flask of 500ml, add 3.0g polylactic acid (D lactic acid mass content 4.25%, model is Ingeo TMBiopolymer 4043D), 5.0g polyvinyl alcohol (model PVA-GL-05), 92g diethylene glycol dimethyl ether, heated to 110°C, and stirred at a speed of 450rpm until the polymer was dissolved. The temperature of the system was lowered to 55° C., and then 100 g of methanol was added dropwise to the above system at a rate of 1.67 g / min. After the dropwise addition, the resulting suspension was filtered, washed with 200 g of deionized water, filtered, and the filtrate was vacuum-dried at 45° C. for 12 hours to obtain 2.7 g of white polylactic acid powder with a volume average diameter of 31.5 μm, the particle size distribution index is 1.7, and the oil absorption is 420mL / 100g.

Embodiment 3

[0043] In a three-necked flask of 500ml, add 5.0g polylactic acid (D lactic acid mass content 1.40%, model is Ingeo TM Biopolymer 6251D), 5.0g polyvinyl alcohol (model PVA-GL-05), 92g N,N-dimethylformamide, heated to 80°C, and stirred at a speed of 450rpm until the polymer was dissolved. The temperature of the system was lowered to 55° C., and then 100 g of methanol was added dropwise to the above system at a rate of 1.67 g / min. After the dropwise addition, the resulting suspension was filtered, washed with 200 g of deionized water, filtered, and the filtrate was vacuum-dried at 45° C. for 12 hours to obtain 2.7 g of white polylactic acid powder with a volume average diameter of 15.8 μm, the particle size distribution index is 1.8, and the oil absorption is 370mL / 100g.

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Abstract

The invention discloses a preparation method of polylactic acid particles. The method mainly comprises the following steps: dissolving polylactic acid and a water-soluble polymer in a solvent at 80-140 DEG C, cooling to 0-80 DEG C, carrying out solid-liquid separation with a precipitant, and drying to obtain the polylactic acid particles. The method is convenient to operate and mild in conditions, can prepare the polylactic acid particles with different porosity by the aid of the water-soluble polymer through a simple dissolution-precipitation process, and is especially suitable for industrial production. The obtained polylactic acid particles can be widely used in the fields of cosmetic substrates, catalyzed sorption, drug release, biological stents and the like.

Description

technical field [0001] The invention belongs to the field of preparation of polymer microparticles, in particular to a method for preparing polylactic acid microparticles through a dissolution process. Background technique [0002] Polylactic acid is an excellent environment-friendly degradable polymer material with good biocompatibility and biodegradability. It undergoes enzymatic decomposition in the living body and finally forms carbon dioxide and water, which will not accumulate in vital organs. It is thus a suitable substrate for the preparation of microparticles. [0003] As the preparation technology of polylactic acid microparticles, it is currently mainly focused on the top-down process (top-down process) using polymer as the base material. This is mainly because the polymerization conditions of polylactic acid are relatively harsh, requiring vacuum and anhydrous, and the building-up process (building-up process), such as the method of forming polylactic acid parti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/14C08L67/04C08L39/06C08L29/04C08L1/26C08L33/02C08L71/08C08L35/00
Inventor 彭凯欧阳芬张艳红董雷
Owner TORAY ADVANCED MATERIALS RES LAB CHINA
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