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Herbal compositions for treating neurological diseases and improving memory impairment

A neurological disease and composition technology, applied in the field of crude drug compositions, can solve problems such as undeveloped preparations, incompletely ascertained causes of dementia, and restrictions

Inactive Publication Date: 2014-01-22
VIROMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, side effects of hepatotoxicity are known to be found in the case of tacrine (Leonard, World Psychiatry (World Psychiatry) 3:84-88 (2004)), and in the case of donepezil nausea, vomiting, Diarrhea and other side effects (Burns et al., Dement Geriatr Cogn Disord10:237-244 (1999)), in the case of rivastigmine, central and peripheral cholinergic side effects occurred under high concentration conditions (Leonard, World Psychiatry (World Psychiatry) 3:84-88, 2004), and in the case of galantamine, gastrointestinal side effects occurred (Tariot et al., Nuerology 54:2269-2276, 2000)
In addition, there are memantine (product name: Ebixa) (Reisberg et al., Am J Geriatr Psychiatry 10: 1-122 (2002)) acting on receptors of glutamate and anti- Inflammation, antioxidants, etc., but the causes of dementia have not been fully identified, and the causes are diverse, so the treatment of dementia with drugs targeting specific factors can only be temporary or limited
And, so far, patents related to the composition having the effect of improving memory have been published and registered in Korea, but currently, no preparation with significant effect has been developed

Method used

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  • Herbal compositions for treating neurological diseases and improving memory impairment
  • Herbal compositions for treating neurological diseases and improving memory impairment
  • Herbal compositions for treating neurological diseases and improving memory impairment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0066] experimental design

[0067] Various experiments were carried out in order to grasp the efficacy of a mixture of longan meat, salvia miltiorrhiza and Gastrodia elata as a dementia treatment agent and a memory loss improver. In order to measure the effect of HX107M (see Experimental Example 1) on the cholinergic neurotransmission process associated with the memory loss that occurs in dementia patients, the inhibitory effect on acetylcholine decomposing enzyme (AChE) was confirmed by the AChE activity measurement method. In addition, amyloid beta peptide, which is known as a protein that causes dementia, was injected into the ventricle to pass the water maze test and passive avoidance test in a rat model of induced nerve cell damage. Behavioral tests were used to measure the learning and memory abilities of HX107N, and the degree of nerve cell damage was confirmed by histological tests.

preparation example 1

[0068] Preparation Example 1: Preparation of mixed extracts of longan meat, salvia miltiorrhiza and Gastrodia elata

[0069] Mix the dry crude drugs of longan meat, salvia miltiorrhiza and Gastrodia elata in the weight ratio in Table 1, add water equivalent to 10 times the total weight, and reflux extraction at about 90-100°C for 3 hours. The extract was filtered, concentrated at 60° C., and freeze-dried to obtain a powdery extract.

[0070] Table 1

[0071] Mixed Extract Name

[0072] Table 1 shows the extraction ratios of the three kinds of crude drugs.

preparation example 2

[0073] Preparation Example 2: Preparation of a Single Extract

[0074] Add water equivalent to 10 times to 10 g of dry crude drugs such as longan meat, salvia miltiorrhiza and Gastrodia elata, and reflux extraction at about 90-100 ° C for 3 hours. The extract was filtered, concentrated at 60° C., and freeze-dried to obtain powdery extracts of the four crude drugs.

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Abstract

The present invention relates to a composition for preventing or treating neurological diseases including an extract of Euphoria longan fruit, red sage and Gastrodia elata as an active ingredient. The composition of the present disclosure has a superior effect of inhibiting the activity of acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine directly involved in impairment of cognitive function. In addition, the composition of the present disclosure is safe for the human body since the biologically safe extract of Euphoria longan fruit, red sage and Gastrodia elata is used as the active ingredient.

Description

technical field [0001] The present invention relates to a crude drug composition for preventing or treating neurological diseases or improving brain function or cognitive function, and in more detail relates to a composition for improving neurological diseases comprising extracts of longan meat, salvia miltiorrhiza and Gastrodia elata, to protect Nerve cells, and improve memory. Background technique [0002] Dementia (Dementia) is a syndrome characterized by multiple impairments of cognitive functions as unconsciousness disturbances, and means the loss of a person's mental (intellectual) ability and the ability to perform social activities. That is, dementia is not a disease, but a syndrome that can arise from a variety of causes, with memory impairment, language impairment, visual-spatial cognitive impairment, apraxia, agnosia, decreased numeracy, Symptoms such as frontal lobe and executive function decline. [0003] Dementia can be divided into Alzheimer's dementia, vasc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61K36/537A61K36/8988A61P25/28
CPCA61K36/77A61K36/8988A61K36/537A61P21/00A61P21/02A61P25/00A61P25/14A61P25/16A61P25/18A61P25/24A61P25/28A61P39/02A61P43/00A61P9/00A61K2300/00A61K36/88A61K36/9066A61K45/06
Inventor 李头奭金东植金善嬉
Owner VIROMED CO LTD
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