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Method for preparing watermelon frost and medical application of watermelon frost in resisting infection

A technology of watermelon frost and watermelon, which is applied to medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulas, etc., can solve problems such as unclear mechanisms, unstable quality, and serious pollution, and achieve simplified operations and reduced pollution links Effect

Active Publication Date: 2014-02-05
王秋红 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the traditional preparation method of watermelon frost, the processing is random, the process is not uniform, the pollution is serious, the production time is long, the efficiency is low, the process is complicated, the pollution of human pathogenic bacteria is common in the production, and the mechanism is unclear, the quality is unstable, Unable to meet the needs of modern production, most watermelon cream manufacturers stopped production in the 1970s, and the ancient medicine was on the verge of extinction.

Method used

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  • Method for preparing watermelon frost and medical application of watermelon frost in resisting infection
  • Method for preparing watermelon frost and medical application of watermelon frost in resisting infection
  • Method for preparing watermelon frost and medical application of watermelon frost in resisting infection

Examples

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Effect test

Embodiment 1

[0022] Embodiment one: the preparation of watermelon frost

[0023] Take 10kg of fresh watermelon, chop it and put it into a fermenter, add 1.5kg of Glauber's salt, mix well, and ferment for 15 days at 20°C, stirring regularly during this period. After the fermentation, centrifuge at 4000r for 10min to obtain 7kg of supernatant, freeze-dry to obtain 1.57kg of watermelon frost.

Embodiment 2

[0024] Embodiment two: the preparation of watermelon frost:

[0025] Take 30kg of fresh watermelon, chop it into pieces, put it into a fermenter, add 5kg of Glauber’s salt, mix well, add bacteria, ferment at 20°C for 20 days, stir regularly during the period, and centrifuge at 4000r for 15min after the fermentation is over. 24kg of clear liquid was freeze-dried to obtain 5.52kg of watermelon frost.

Embodiment 3

[0026] Embodiment three: the preparation of methanol extract of watermelon frost

[0027] Take 3kg of self-made watermelon cream, use 8 times the amount of methanol to extract by cold soaking at 20°C for 2 times, each time for 8h, stir, and filter the insoluble Na 2 SO 4 , Combine the filtrates, recover methanol under reduced pressure at 35°C, and obtain 206g of watermelon cream extract.

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Abstract

The invention relates to a method for preparing watermelon frost through fermentation and freeze drying, as well as medical application of the prepared watermelon frost in resisting infection. The preparation method of the watermelon frost is characterized by comprising the steps of preparing fresh watermelon, cutting the watermelon and adding in a fermentation tank or a container, adding a certain concentration of mirabilite, uniformly mixing, fermenting for 7-20 days at 5-25 DEG C through a high-salinity strain or a fermentation strain separated through a biotechnological method, and regularly stirring during the period to enhance dissolved oxygen; after the fermentation, centrifuging and reserving supernatant liquid, and freeze-drying the supernatant liquid to obtain the watermelon frost. The method for preparing the watermelon frost, obviously different from a conventional production way, has many advantages. The prepared watermelon frost and extract thereof have obvious antibacterial activity and can be prepared into various appropriate preparations to be used for treating various infectious diseases in oral cavity, mucous membrane and skin, such as stomatitis, dental ulcer, acute and chronic sphagitis, amygdalitis and otitis media.

Description

technical field [0001] The present invention relates to a method for fermenting and preparing watermelon frost, and the medical use of the watermelon frost and its 95% ethanol (or other low-molecular alcohol) extract as antibacterial activity for treating oral cavity, mucous membrane and skin infectious diseases : Stomatitis, mouth ulcers, pharyngitis, tonsillitis and otitis media, etc. Background technique [0002] According to the traditional theory of traditional Chinese medicine, watermelon frost is the fine crystallization of Glauber's salt processed by dialysis frosting method from the ripe fresh fruit of Cucurbitaceae watermelon Citrullus lanatus (Thunb.) Matsumu.et Nakai and skin salt (crude Glauber's salt). The traditional processing method is: take fresh watermelon and chop it into pieces, put it in an unglazed earthen jar, layer watermelon and layer Glauber's salt, seal the mouth tightly, hang it in a cool and ventilated place, and white crystals will precipitate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61P31/04
Inventor 王秋红辛萍薛娟苏阳曹琦李斌匡海学
Owner 王秋红
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